Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties

Lancz, Kinga; Murínová, Ľubica Palkovičová; Patayová, Henrieta; Drobná, Beata; Wimmerová, Soňa; Šovčíková, Eva; Kováč, Ján; Farkašová, Dana; Hertz‐Picciotto, Irva; Jusko, Todd A.; Trnovec, T.

doi:10.1016/j.ijheh.2014.08.003

Cited by 37 publications

(37 citation statements)

References 98 publications

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“…In secondary analyses using this value, we derived a ratio of 1.94, which was not meaningfully different from our ratio of 2.18 (data not shown). Here and in our study (Lancz et al, 2015), the lipid level might have been influenced by labor. Furthermore, in some of the reviewed papers the authors reported that blood and milk samples from the same individual were not collected at the same time.…”

Section: Discussionsupporting

confidence: 41%

“…With HCB serum concentration expressed as wet weight, we calculated the concentration of total lipids in serum as 10 mg lipids/ml serum. We observed this value in 1065 subjects (Lancz et al, 2015) (Table 2). The descriptive statistical data on total lipid concentration in mother and cord serum samples are shown in Table 2 (Lancz et al, 2015).…”

Section: Resultsmentioning

confidence: 56%

“…However the relationship between the concentration of the compounds in milk and the fetus is not straightforward. In our paper, we derive parameters necessary for conversion of breast milk HCB concentrations into cord serum levels, both, wet weighed and lipid adjusted, based on the extant published literature and our own data (Patayová et al, 2013; Lancz et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

“…Percentage of samples with concentration of HCB ≥ LOD was 96.3%. For switching between wet weight and lipid based data we used our data on lipid concentration in 1065 paired maternal and cord blood serum (Lancz et al, 2015). Lipid concentration was measured using the enzymatic summation method (Akins et al, 1989) (item 3).…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Partitioning of hexachlorobenzene between human milk and blood lipid

Murínová

Wimmerová

Lancz

et al. 2017

Environmental Pollution

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In epidemiological studies on the toxic effects of prenatal exposure to hexachlorobenzene (HCB), researchers report HCB concentrations, either as wet-weight or per lipid weight basis, in matrices like breast milk, and maternal and cord blood. Conversion of exposures across matrices is needed for comparisons of concentrations and dose effect across cohorts. Using data from a birth cohort study in eastern Slovakia, we derived the maternal blood to cord blood HCB concentration ratio utilizing measured concentrations in 1027 paired maternal and cord blood samples, on a per-lipid basis. In addition to data from the Slovak study, the maternal milk to maternal serum ratio was summarized from 23 published studies on partitioning of HCB between human milk lipid and blood lipid. We identified two distinct groups of milk:blood ratios, those ≤0.45 and those ≥0.85. We assumed that using partition ratios ≤0.45 will underestimate HCB exposure estimates. Taking into account this precautionary measure, we suggest a conversion ratio of 1.21, which is the median of the 16 ratios identified in our literature review. We consider our estimate as conservative and providing appropriate safety in risk analysis.

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Section: Discussionsupporting

confidence: 41%

Section: Resultsmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Partitioning of hexachlorobenzene between human milk and blood lipid

Murínová

Wimmerová

Lancz

et al. 2017

Environmental Pollution

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“…Nearly all PCBs are found in higher levels in maternal than cord serum (90), with the exception of only a few congeners (91). One recent study suggested that lower chlorinated PCB congeners have a higher maternal-fetal transfer rate compared to higher chlorinated congeners (92) but this pattern is not supported by a systematic review and other studies (90,93,94). As PCB congener molecular weight (92,94) or lipophilicity (94) increase, placental transfer decreases.…”

Section: Placental Transfer and Fetal Burdenmentioning

confidence: 91%

Environmental influences on reproductive health: the importance of chemical exposures

Wang

Padula

Sirota

et al. 2016

Fertility and Sterility

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Unstructured Abstract Chemical exposures during pregnancy can have a profound and life-long impact on human health. Due to the omnipresence of chemicals in our daily life, there is continuous contact with chemicals in food, water, air and consumer products. Consequently, human biomonitoring studies show that pregnant women around the globe are exposed to a variety of chemicals. In this review, we provide a summary of current data on maternal and fetal exposure as well as health consequences from these exposures. We review several chemical classes including polychlorinated biphenyls (PCBs), perfluoroalkyl substances (PFAS), polybrominated diphenyl ethers (PBDEs), phenols, phthalates, pesticides, and metals. Additionally, we discuss environmental disparities and vulnerable populations, and future research directions. We conclude by providing some recommendations for prevention of chemical exposure and its adverse reproductive health consequences.

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The spatial distribution of human exposure to PCBs around a former production site in Slovakia

Wimmerová

Watson²,

Drobná

et al. 2015

Environ Sci Pollut Res

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We evaluated concentrations of 15 PCB congeners in blood serum of 2,047 adults, 431 8-9-years old children and 1,134 mother-child pairs born in 2001-2003. These subjects were long-standing residents living up to 70 km (to the north) and up to 50 km (to the south) of the former Chemko Strážske PCB production facility in the Michalovce district of Slovakia. We plotted serum concentration against distance from the plant both with and without consideration of the direction of their homes from the site. The decrease in exposure with distance could be described by an exponential function which was dependent on direction and climatic parameters. By kriging we created maps depicting predicted isoconcentration contours for sex- and age-adjusted serum concentration of ΣPCBs for the same group of children, adults and mothers. The principle of our risk analysis was to relate serum concentration data, reflecting PCB body burden, using the critical concentrations established by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES 2010) as thresholds below which the probability of effects on health is regarded as negligible. We conclude that 10 years ago around 200,000 residents were at risk in this densely populated area. Exposure has since decreased but the mechanism for this has not yet been studied.

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Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties

Cited by 37 publications

References 98 publications

Partitioning of hexachlorobenzene between human milk and blood lipid

Partitioning of hexachlorobenzene between human milk and blood lipid

Environmental influences on reproductive health: the importance of chemical exposures

The spatial distribution of human exposure to PCBs around a former production site in Slovakia

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