Distinct Representation and Distribution of Visual Information by Specific Cell Types in Mouse Superficial Superior Colliculus

Gale, Samuel D.; Murphy, Gabe J.

doi:10.1523/jneurosci.2768-14.2014

Cited by 206 publications

(409 citation statements)

References 61 publications

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“…Sparse projections could also be detected in the dLGN (Fig. 3E), as described previously (Gale and Murphy, 2014). Together, these experiments demonstrate that a small population of TG cells are GABAergic and sparsely innervate the dLGN.…”

Section: The Vast Majority Of Tectogeniculate Projections Are Non-gabsupporting

confidence: 88%

“…A recent study of mouse NFV cells reported that all were direction selective (Gale and Murphy, 2014).…”

Section: Tectogeniculate Pathwaymentioning

confidence: 99%

“…Neurons that innervate the dLGN are always located in the upper onehalf of the stratum griseum superficiale (SGS) and the majority of these cells are narrow field vertical cells (NFV), whereas those neurons that project to the pulvinar are located in the lower half of the SGS and stratum opticum (SO), and the majority of these cells are wide field vertical cells (WFV) (Mooney et al, 1988;Fredes et al, 2012;Gale and Murphy, 2014). It has also been noted that the somata of tectopulvinar cells are larger than those of tectogeniculate neurons (Albano et al, 1979;Kawamura et al, 1980;Caldwell and Mize, 1981;Graham and Berman, 1981;Harrell et al, 1982).…”

Section: Tectothalamic Cellsmentioning

confidence: 99%

“…WFV cells have large receptive fields and respond to small stimuli that move in any direction. In contrast, NFV cells may be specialized to code more detailed motion parameters based on their small receptive fields and strong direction selectivity (Gale and Murphy, 2014).…”

Section: Tectothalamic Cellsmentioning

confidence: 99%

“…Like the dorsolateral shell of the dLGN, the SGS is innervated by DSGCs (Huberman et al, 2009;Kay et al, 2011;Rivlin-Etzion et al, 2011;Dhande et al, 2013a) and contains neurons that respond selectively to visual motion, some of which have been identified as TG cells (Mooney et al, 1985(Mooney et al, , 1988Waleszczyk et al, 2004;Wang et al, 2010;Gale and Murphy, 2014;Inayat et al, 2015). Thus, the dorsolateral shell of the dLGN appears to receive two distinct sources of direction-selective signals, one from the retina and one from the SC.…”

Section: Introductionmentioning

confidence: 99%

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Circuits for active vision : parallel tectothalamocortical visual pathways in the mouse.

Zhou¹

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Section: The Vast Majority Of Tectogeniculate Projections Are Non-gabsupporting

confidence: 88%

“…A recent study of mouse NFV cells reported that all were direction selective (Gale and Murphy, 2014).…”

Section: Tectogeniculate Pathwaymentioning

confidence: 99%

Section: Tectothalamic Cellsmentioning

confidence: 99%

Section: Tectothalamic Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circuits for active vision : parallel tectothalamocortical visual pathways in the mouse.

Zhou¹

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Axon terminals from the nucleus isthmi pars parvocellularis control the ascending retinotectofugal output through direct synaptic contact with tectal ganglion cell dendrites

González-Cabrera

Garrido-Charad

Mpodozis

et al. 2015

J of Comparative Neurology

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The optic tectum in birds and its homologue the superior colliculus in mammals both send major bilateral, nontopographic projections to the nucleus rotundus and caudal pulvinar, respectively. These projections originate from widefield tectal ganglion cells (TGCs) located in layer 13 in the avian tectum and in the lower superficial layers in the mammalian colliculus. The TGCs characteristically have monostratified arrays of brush-like dendritic terminations and respond mostly to bidimensional motion or looming features. In birds, this TGC-mediated tectofugal output is controlled by feedback signals from the nucleus isthmi pars parvocellularis (Ipc). The Ipc neurons display topographically organized axons that densely ramify in restricted columnar terminal fields overlapping various neural elements that could mediate this tectofugal control, including the retinal terminals and the TGC dendrites themselves. Whether the Ipc axons make synaptic contact with these or other tectal neural elements remains undetermined. We double labeled Ipc axons and their presumptive postsynaptic targets in the tectum of chickens (Gallus gallus) with neural tracers and performed an ultrastructural analysis. We found that the Ipc terminal boutons form glomerulus-like structures in the superficial and intermediate tectal layers, establishing asymmetric synapses with several dendritic profiles. In these glomeruli, at least two of the postsynaptic dendrites originated from TGCs. We also found synaptic contacts between retinal terminals and TGC dendrites. These findings suggest that, in birds, Ipc axons control the ascending tectal outflow of retinal signals through direct synaptic contacts with the TGCs.

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Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus

Byun

Kwon

Ahn

et al. 2016

J of Comparative Neurology

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The superior colliculus (SC) is a midbrain center involved in controlling head and eye movements in response to inputs from multiple sensory modalities. Visual inputs arise from both the retina and visual cortex and converge onto the superficial layer of the SC (sSC). Neurons in sSC send information to deeper layers of SC and to thalamic nuclei that modulate visually guided behaviors. Presently, our understanding of sSC neurons is impeded by a lack of molecular markers that define specific cell types. To better understand the identity and organization of sSC neurons, we took a systematic approach to investigate gene expression within four molecular families: transcription factors, cell adhesion molecules, neuropeptides and calcium binding proteins. Our analysis revealed 12 molecules with distinct expression patterns in mouse sSC: cadherin 7, contactin 3, netrin G2, cadherin 6, protocadherin 20, retinoid-related orphan receptor β, brain-specific homeobox/POU domain protein 3b, Ets variant gene 1, substance P, somatostatin, vasoactive intestinal polypeptide and parvalbumin. Double labeling experiments, by either in situ hybridization or immunostaining, demonstrated that the 12 molecular markers collectively define 10 different sSC neuronal types. The characteristic positions of these cell types divide sSC into 4 distinct layers. The 12 markers identified here will serve as valuable tools to examine molecular mechanisms that regulate development of sSC neuron types. These markers could also be used to examine the connections between specific cell types that form retinocollicular, corticocollicular or colliculothalamic pathways.

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Distinct Representation and Distribution of Visual Information by Specific Cell Types in Mouse Superficial Superior Colliculus

Cited by 206 publications

References 61 publications

Circuits for active vision : parallel tectothalamocortical visual pathways in the mouse.

Circuits for active vision : parallel tectothalamocortical visual pathways in the mouse.

Axon terminals from the nucleus isthmi pars parvocellularis control the ascending retinotectofugal output through direct synaptic contact with tectal ganglion cell dendrites

Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus

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