Dietary habits changes and quality of life in patients undergoing chemotherapy for epithelial ovarian cancer

Mardas, Marcin; Jamka, Małgorzata; Mądry, Radosław; Walkowiak, Jarosław; Krótkopad, Marietta; Stelmach-Mardas, Marta

doi:10.1007/s00520-014-2462-2

Cited by 33 publications

(15 citation statements)

References 28 publications

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“…[ 20 ] gastrointestinal symptoms (nausea indicated in 39%, vomiting in 27% and constipation in 41% of patients) potentially influencing weight loss are prevalent early in the course of cancer patients with regard to lower caloric intake, nutritional status and prior therapy experience. However, in current study only small percentage of patients was underweight, which stay in line with previously published data [ 11 , 21 ]. In early 90’s has been already indicated that a significant percentage of patients who even received exclusive oral feeding did not cover a minimum acceptable quantity of their energy requirements [ 22 ].…”

Section: Discussionsupporting

confidence: 93%

“…However, none from the examined patients consumed such products, which could not influence the obtained results of energy intake. We have already reported in previously published study that patients suffering from ovarian cancer did not reach even 25 kcal per kg of body weight during the day [ 11 ]. The changes in energy and nutrients intake are especially visible when we take into account separated cycles of cytotoxic chemotherapy [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previously validated a 77-item questionnaire [ 11 , 12 ] was used to evaluate the incidence of chemotherapy induced gastrointestinal symptoms and describe an association between them and selected food products. Patients were asked to answer question “how often have you had”: nausea, vomiting, constipation and diarrhea on a 6-point scale ranging from 0 (“Never”) to 5 (“very often”).…”

Section: Methodsmentioning

confidence: 99%

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Link between diet and chemotherapy related gastrointestinal side effects

Mardas¹,

Mądry²,

Stelmach-Mardas³

2017

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Aim of the studyTo evaluate an association between food products consumption, dietary intake and the incidence of selected gastrointestinal symptoms (nausea, vomiting, diarrhea and constipation) in cancer patients undergoing chemotherapy.Material and methodsFifty six women receiving chemotherapy for ovarian cancer were eligible for the study. Anthropometrical measurements were assessed. The dietary intake was evaluated by 24-hours food records. The association between the consumption of selected food products and gastrointestinal symptoms incidences was assessed by modified semi-quantitative food frequency questionnaire including 77-different food items that was developed and applied in cancer patients undergoing chemotherapy.ResultsBMI values indicated 9%, 45%, 30% and 16% of patients as underweight, normal weight, overweight and obese respectively. Only 23% and 32% of patients never experienced nausea and constipation when 43% and 45% never experienced vomiting and diarrhea. Nausea was promoted by oils, constipation by chocolate and chocolate products and diarrhea by dairy products, stone fruit and apple. Significant inverse correlations were found between vomiting and the intake of energy, fat, protein, carbohydrates, B groups vitamins, vitamin D, phosphorus and zinc. The difference in energy intake between marginal values of vomiting incidence exceeded 400 kcal.ConclusionsDietary intake as well as specific food products influence on gastrointestinal side effect of chemotherapy in cancer patients. The dietary approach based on either exclusion or limited intake of selected food products and improvement of diet could reduce and prevent chemotherapy induced gastrointestinal symptoms therefore should be taken under consideration in clinical practice.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Link between diet and chemotherapy related gastrointestinal side effects

Mardas¹,

Mądry²,

Stelmach-Mardas³

2017

Self Cite

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“…Although the 2006 European Society for Parenteral and Enteral Nutrition (ESPEN) non-surgical oncology guidelines on enteral nutrition suggest that cancer patients should consume at least 1.2-2.0 g protein/kg body weight per day (16), most cancer patients do not reach this level via the diet and/or through nutritional supplementation (11, 17, 18). Besides a reduced appetite (19, 20), the available nutritional supplements for cancer patients are often energy-dense and have a limited amount of high quality protein.…”

Section: Introductionmentioning

confidence: 99%

Protein anabolic resistance in cancer

Engelen

Meij

Deutz

2016

Current Opinion in Clinical Nutrition and Metabolic Care

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Purpose of review Preventing unintentional weight and muscle loss is of crucial importance to maintain the condition and well-being of patients with cancer, improve treatment response and tolerance, and prolong survival. Anabolic resistance might explain why some cancer patients do not respond to nutritional intervention but does recent evidence actually support this? We will discuss recent literature that cast doubt on attenuated anabolic potential in cancer. Recent findings Although anabolic resistance was observed in the past, more recent studies have shown that advanced cancer patients have an anabolic potential after intake of high-quality proteins. Furthermore a consistent linear relationship is observed in cancer between (essential) amino acid availability from the diet and net protein gain. The studied cancer patients however were often characterized by a normal or obese body weight, following the trend in the general population, and mild systemic inflammation. Factors like recent chemotherapy, surgery or cachexia do not seem to attenuate the anabolic potential to feeding. Summary Cancer patients have a normal anabolic potential which relates to the amount of essential amino acids in the meal. It remains to be determined if this is also the case in weak cancer patients with a short life expectancy and high systemic inflammation.

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“…While less than 10% of women are underweight, 56 30% to 67% are malnourished at diagnosis, based on nutrition assessment tools such as the Patient-Generated Subjective Global Assessment and the Nutritional Risk Index. 44,52,57,58 The presence of ascites and a high body fat percentage at any time point will ''inflate'' BMI values and mask muscle wasting, a consequence of malnourishment. 59 In addition to BMI, body composition measures can provide much needed objective data to identify OC survivors with low muscle mass and/or excess body fat in need of dietary and exercise interventions.…”

Section: Body Weightmentioning

confidence: 99%

A Physiological Profile of Ovarian Cancer Survivors to Inform Tailored Exercise Interventions and the Development of Exercise Oncology Guidelines

Schofield

Newton

Galvão

et al. 2017

Int J Gynecol Cancer

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Our review suggests that ovarian cancer survivors could benefit from physical activity and exercise oncology interventions aimed at addressing detrimental changes to physiological status due to disease and treatment. However, current knowledge gaps regarding the physiological characteristics of ovarian cancer survivors throughout the entire survivorship spectrum challenge the development of tailored exercise intervention studies and exercise oncology guidelines.

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Dietary habits changes and quality of life in patients undergoing chemotherapy for epithelial ovarian cancer

Abstract: Women undergoing chemotherapy for ovarian cancer change their dietary habits in a pro healthy direction, and these changes are more expressed in patients undergoing subsequent-line chemotherapy.

Cited by 33 publications

References 28 publications

Link between diet and chemotherapy related gastrointestinal side effects

Link between diet and chemotherapy related gastrointestinal side effects

Protein anabolic resistance in cancer

A Physiological Profile of Ovarian Cancer Survivors to Inform Tailored Exercise Interventions and the Development of Exercise Oncology Guidelines

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