Thirty-Fifth Anniversary of the Optical Affinity Sensor for Glucose

Abstract

The article "Affinity Sensors for Individual Metabolites" 1 by Schultz and Sims in 1979 was to my knowledge the first publication that demonstrated the concept of constructing biosensors based on the principles of immunoassays and optical detection. An illustration of how this principle could be implemented into a sensor was shown in Figure 1 of this article and reproduced here. This preliminary concept was fully evaluated in a single optical fiber glucose sensor system described in detail in a 1982 publication. 2 The relevance of this work has become apparent in recent years with at least 2 clinical trials under way 3-5 and a recent optimistic review of optical methods by Klonoff. 6 The impetus for my involvement in glucose monitoring started with a vision of physicians at the University of Michigan who anticipated the advantages of a regulated insulin infusion system for the treatment of diabetic patients. They were confident that the technology for reliable insulin infusion systems could be readily developed, but the technology for the continuous monitoring of glucose was the weak link. I was challenged to develop a method for reliably monitoring glucose continuously. During this period I was 552477D STXXX10.

Biosensors for the Multiplex Detection of Inflammatory Disease Biomarkers

“…The incorporation of the enzyme glucose oxidase in an electrochemical sensor for detection and measurement of glucose in blood plasma revolutionized the way diabetes is diagnosed and monitored [ 6 ]. From humble beginnings that included simple enzyme electrodes, the field of biosensors has steadily progressed with increasing levels of sophistication, leading to the development of immunosensors, optides, optical affinity sensors, lectin-based sensors, and organ on chip-based technologies and nanobiosensors [ 7 , 8 , 9 , 10 , 11 ]. Biosensors have important applications in medical diagnostics, personalized medicine, the food industry, and substance testing laboratories.…”