Systematic review: Histological remission in inflammatory bowel disease. Is ‘complete’ remission the new treatment paradigm? An IOIBD initiative

Bryant, Robert V.; Winer, Shawn; Travis, Simon; Riddell, Robert H.

doi:10.1016/j.crohns.2014.08.011

Cited by 239 publications

(206 citation statements)

References 116 publications

Supporting

Mentioning

200

Contrasting

Unclassified

Order By: Relevance

“…A case of a hospitalized CD patient with an intestinal methicillin-resistant S. aureus infection has been previously reported (28). In addition, a previous study demonstrated that S aureus infection increased and was associated with the risk of mortality in hospitalized patients with IBD (29). However, none of the patients enrolled in the present study were hospitalized nor did they exhibit clinical manifestations of a S. aureus infection.…”

Section: B Acontrasting

confidence: 45%

Gene expression alterations in inflamed and unaffected colon mucosa from patients with mild inflammatory bowel disease

Lian

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. An endoscopic examination is currently the most reliable method for monitoring disease activity in patients with inflammatory bowel disease (IBD). However, endoscopic evaluations are unable to detect mucosal inflammation at the earliest stages. The present study aimed to evaluate the molecular profiles of inflamed and unaffected colon mucosa from patients with mild Crohn's disease (CD) and ulcerative colitis (UC), in order to identify a more sensitive method for monitoring mucosal impairment. Patients were recruited and colon biopsies from the inflamed and the normal-appearing mucosa of patients with mild IBD were obtained by colonoscopy. Gene expression analysis was performed using microarrays, after which Gene Ontology and clustering were performed using bioinformatics. In addition, the levels of inflammatory cytokines were analyzed by reverse transcription-quantitative polymerase chain reaction. A total of 620 genes in the inflamed and 210 genes in the unaffected colon mucosa with at least a 3-fold change, as compared with healthy controls, were detected in patients with mild CD, and 339 genes in the inflamed and 483 genes in the unaffected colon mucosa were detected in patients with mild UC. Heat mapping demonstrated a similarity in the gene alteration patterns, and altered transcripts overlapped, between the inflamed and unaffected colon mucosa. Interferon-γ and interleukin-17 mRNA levels were comparably elevated in the inflamed and unaffected colon mucosa from patients with IBD. Marked gene expression alterations were detected in the inflamed and unaffected colon mucosa from patients with mild IBD, and these showed marked similarity and overlap between the two groups. The results of the present study suggested that inflammation was not limited to the endoscopic lesions and that gene expression profiling may be considered a sensitive tool for monitoring mucosal inflammation, predicting relapses and optimizing therapeutic strategies for patients with IBD.

show abstract

Section: B Acontrasting

confidence: 45%

Gene expression alterations in inflamed and unaffected colon mucosa from patients with mild inflammatory bowel disease

Lian

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…However, from an histological point of view, recovery is often incomplete and microscopic evidence of inflammation persists in 16-100% of the patients with endoscopically quiescent colitis 5,8 . In fact, histologic changes tend to lag behind clinical response and/or remission after starting UC treatment.…”

Section: Introductionmentioning

confidence: 99%

“…In fact, histologic changes tend to lag behind clinical response and/or remission after starting UC treatment. This quiescent inflammation puts patients at risk of further disease relapses or of developing disease complications 5,8 . On the other hand, histological remission was shown to decrease colorectal cancer risk in UC 7,9 .…”

Section: Introductionmentioning

confidence: 99%

“…Mucosal healing (MH), routinely assessed by endoscopy, is considered a prognostic marker, as it has been described as able to predict disease outcomes such as steroid need, hospitalization and colectomy [3][4][5] . Therefore, MH has emerged as an important clinical factor in disease progression, both for Crohn's disease and UC patients 3,4,6,7 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocalin in Evaluating Subclinical Inflammation in UlceRaTIVE Colitis—the ACERTIVE study

Magro

Lopes

Coelho

et al. 2016

ECCOJC

View full text Add to dashboard Cite

“…The term of complete remission proposed by Bryan et al should be preferred as it implies concordance between clinical, endoscopic and histological remission and may be the ultimate treatment endpoint [25].…”

Section: Histological Mucosal Healingmentioning

confidence: 99%

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Auzoux¹,

Boschetti²,

Lahlou³

et al. 2017

J Clin Gastroenterol Hepatol

View full text Add to dashboard Cite

In recent decades, the advent of biological therapy has changed the treatment of inflammatory bowel disease (IBD) and has opened new therapeutic endpoints such as mucosal healing (MH). MH incorporated with clinical remission presents a new concept: deep remission, which correlates with a decrease in hospitalization and surgery and improvement in the patient's quality of life. Several techniques can be used to assess mucosal healing such as endoscopy which remains the gold standard. But considerable variations may exist in the interpretation of the definition of mucosal healing which may also be histological or evaluated by radiological or biological methods. Thus, it is important to study mucosal inflammation by endoscopic scores and by new, more sensitive techniques such as videocapsule endoscopy (VCE), magnetic resonance enterography (MRE), chromoendoscopy and confocal laser endomicroscopy (CLE). Biomarkers, such as fecal calprotectin (FC) were also studied in the evaluation of MH and showed positive results. These methods are currently the subject of validation studies.

show abstract

Systematic review: Histological remission in inflammatory bowel disease. Is ‘complete’ remission the new treatment paradigm? An IOIBD initiative

Cited by 239 publications

References 116 publications

Gene expression alterations in inflamed and unaffected colon mucosa from patients with mild inflammatory bowel disease

Gene expression alterations in inflamed and unaffected colon mucosa from patients with mild inflammatory bowel disease

Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocalin in Evaluating Subclinical Inflammation in UlceRaTIVE Colitis—the ACERTIVE study

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Contact Info

Product

Resources

About