Associations between erythrocyte membrane fatty acid compositions and insulin resistance in obese adolescents

Omer, Gunes; Tascilar, Emre; Sertoğlu, Erdim; Taş, Ahmet; Serdar, Muhittin; Kaya, Güven; Kayadibi, Hüseyin; Ozcan, Okan

doi:10.1016/j.chemphyslip.2014.09.006

Cited by 15 publications

(15 citation statements)

References 31 publications

(29 reference statements)

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“…The multivariate models were most significant for the FA composition of SAT depots, highlighting a stronger influence of SAT FA metabolism over dietary FA intake (reflected by RBC-TPL) on obesity-associated metabolic risk in these women. These findings support the contribution of excess SAT accumulation in the incidence of metabolic disorders [14,22,42].…”

Section: Discussionsupporting

confidence: 84%

“…Long-term dietary fat intake is more accurately evaluated by the measurement of the FA composition of red blood cell total phospholipids (RBC-TPL), compared to plasma or serum FA profiles which only reflect the dietary FA intake of individuals for the last 2-3 weeks [12][13][14][15]. Alterations in RBC-TPL FA composition have been reported in insulin-resistant patients and were suggested to be derived either from modifications in dietary FA intake or changes in desaturase enzymes activities such as stearoyl-CoA desaturase-1 (SCD1), delta-5-desaturase (D5D) and delta-6 desaturase (D6D) [16].…”

Section: Introductionmentioning

confidence: 99%

“…Although VAT accumulation is considered to be highly linked to adverse metabolic effects [21], SAT accumulation can also contribute to the development of T2D, especially among black SA women, with several putative mechanisms identified [3]. Among others, increasing SAT basal and/or stimulated lipolysis during obesity elevates circulating free fatty acid (FFA) concentrations, which may interfere with glucose transport/uptake and phosphorylation activity, contributing to impaired peripheral insulin sensitivity [14,22]. Furthermore, these FFAs can be redirected to ectopic regions including VAT, thus, increasing obesity-associated metabolic risks [21].…”

Section: Introductionmentioning

confidence: 99%

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Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study

et al. 2020

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Background and Aims: During positive energy balance, excess lipid storage in subcutaneous adipose tissue (SAT) is associated with increased lipolysis. Elevated circulating fatty acid (FA) concentrations from both SAT lipolysis and dietary fat intake may result in visceral adipose tissue (VAT) accumulation, impairment of glucose metabolism, altogether increasing obesity-associated metabolic risks. We aimed to test the hypothesis that FA composition of red blood cell total phospholipids (RBC-TPL) and SAT is associated with body fat centralisation (VAT/SAT ratio) and insulin sensitivity (SI) in black South African women with obesity. Methods: Participants’ (n = 41) body fat composition and distribution, SI, and RBC-TPL, abdominal and gluteal SAT (gSAT) FA composition (gas-liquid chromatography) were measured. Results: RBC-TPL contained higher proportions of saturated fatty acids (SFAs) than SAT (p < 0.001), which were associated with lower SI (p < 0.05). Mono-unsaturated fatty acids (MUFAs) and stearoyl-CoA desaturase-1 (SCD1)-16 were lower, while poly-unsaturated fatty acids (PUFAs), and delta-5 and delta-6 desaturase indices were higher in RBC-TPL than SAT (p < 0.001). Interestingly, FA profiles differed between SAT depots with higher SFAs and lower MUFAs, SCD1-16 and SCD1-18 indices in abdominal compared to gluteal SAT (p < 0.01). In both SAT depots, higher SFAs and lower PUFAs (n-3 and n-6) correlated with lower VAT/SAT ratio; and lower PUFAs (n-3 and n-6) and higher total MUFA correlated with higher SI. Conclusion: Our findings confirm the relationships between the FA composition of RBC-TPL and SAT and metabolic risk in black women with obesity, which are dependent on both the FA class, and the tissue type/blood compartment in which they are distributed.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study

et al. 2020

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“…However, in the literature, there are several chromatographic methods, which can analyze several FAs, both esterified fatty acids (EFAs) and NEFAs, simultaneously [4,5]. Measurement of concentration of FA subtypes (EFAs and NEFAs), calculation of percentage of FA fractions or ratio of some fractions of FAs might be a better indicator to understand the association of FAs with obesity and IR in adolescents [6]. Accordingly, detailed analysis of FA subtypes can provide valuable information in management of dietary intake or supplementation of FAs, which are deficient in adolescents with obesity and IR.…”

mentioning

confidence: 99%

Use of proper diagnostic methods will provide more reliable results

Sertoğlu¹,

Uyanık²,

Kayadibi

et al. 2015

Steroids

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“…Consequently, because erythrocytes have a rather long life span (≈120 days), the FA profile is considered a better indicator of long-term FA intake compared with the plasma lipids. 2,3 In this respect, the erythrocytes are more stable, and it would be more valuable and indeed proper to measure their FA concentration to assess the functional activity of FAs. Therefore, measurement of erythrocyte membrane PUFA levels may be more significant in such studies.…”

mentioning

confidence: 99%

Letter by Sertoglu et al Regarding Article, “Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study”

Sertoğlu¹,

Kayadibi

Uyanık³

2015

Circulation

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We read with great interest the recently published article by Wu et al 1 in which the authors investigated the associations of circulating omega-6 (ω-6) polyunsaturated fatty acids (PUFAs), including linoleic acid, γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid, with total and cause-specific mortality in a communitybased US cohort. They concluded that high circulating linoleic acid, but not other ω-6 PUFAs, was inversely associated with total and coronary heart disease mortality in older adults. However, we think that there are some points that should be emphasized about this study.First, as is known, plasma/serum samples are more commonly analyzed for the assessment of an individual's fatty acid (FA) status because the FA composition of plasma reflects recent dietary fat intake.2 However, plasma FA levels are subject to multiple different dietary influences. The plasma FA profile may be determined not only by the time elapsed since the ingestion of fat-containing foods but also by the type of dietary FA subgroups ingested. Consequently, because erythrocytes have a rather long life span (≈120 days), the FA profile is considered a better indicator of long-term FA intake compared with the plasma lipids. 2,3 In this respect, the erythrocytes are more stable, and it would be more valuable and indeed proper to measure their FA concentration to assess the functional activity of FAs. Therefore, measurement of erythrocyte membrane PUFA levels may be more significant in such studies.

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Associations between erythrocyte membrane fatty acid compositions and insulin resistance in obese adolescents

Cited by 15 publications

References 31 publications

Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study

Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study

Use of proper diagnostic methods will provide more reliable results

Letter by Sertoglu et al Regarding Article, “Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study”

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