Improvement in skin wrinkles using a preparation containing human growth factors and hyaluronic acid serum

Lee, Do‐Hyun; Oh, Il Young; Koo, Kyo Tan; Suk, Jang Mi; Jung, Sang Wook; Park, Jin Oh; Kim, Beom Joon; Choi, Yoo Mi

doi:10.3109/14764172.2014.968577

Cited by 17 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The importance of FGF10 for developmental organogenesis has suggested that it may be a useful factor for regenerative therapies in adult tissues ( Lee et al, 2015 ; Zheng et al, 2015 ). During SG regeneration in a murine duct ligation injury model, both Fgf10 and Sox9 were upregulated ( Chatzeli et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

et al. 2022

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

et al. 2022

View full text Add to dashboard Cite

“…In 20 females with moderate facial skin aging, significant improvement was observed after 2 months of treatment with a HA serum (mixed with acetyl glucosamine and gamma‐amino butyric acid) for the following: hydration (via corneometry), moisture, elasticity, and lightening of the skin. 35 Finally, topical HA with growth factor has been found to diminish periorbital wrinkles in a 8‐week trial, 36 as well as to reduce fine lines and other signs of facial skin aging in a 12‐week study. 37 …”

Section: Resultsmentioning

confidence: 99%

Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

Bravo¹,

Correia²,

Gonçalves³

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

Skin aging goes beyond a chronological process and also results from extrinsic factors referred to as the exposome. Hyaluronic acid (HA) is an important component of the extracellular matrix, with loss starting at 25 years old. While many studies of HA concern topical use, few literature reviews only address the use of topical HA in dermatology. This review describes the different characteristics of HA-containing cosmeceuticals, with a focus on skin aging and the impact of exposome factors on HA synthesis and degradation. A review was performed using the terms HA, hyaluronan, topical, dermatology, cosmetic, aging treatment, exposome, and cosmeceuticals.Results are also presented from a recent randomized controlled trial (RCT), which investigated the additional benefit of using a HA epidermic filler (HA-filler serum) combined with Botulinum toxin type A (BoNTA) to treat signs of skin aging. Subjects were randomized to two groups: HA-filler serum starting 24 h after the BoNTA injection then twice daily for 24 weeks, or the control group, which received BoNTA. HA is a key ingredient used in cosmeceuticals for its hydration/antiaging properties (hygroscopic, rheological, and viscoelastic). Several clinical studies indicate that HA is both well tolerated and effective, adjuvant to both post-surgical and facial rejuvenation procedures. In the RCT, one of few studies to combine BoNTA and HA with a 6-month follow-up, the HA-filler serum lengthened the duration of BoNTA's effect in reducing wrinkles. Numerous studies support HA-based cosmeceuticals as a noninvasive, effective solution for improving skin hydration and rejuvenation.

show abstract

“…Moreover, HA was shown that can be used as a vehicle for topical application of drugs to the skin [40,[49][50][51]. Topical application of different molecular weights of HA formulations has been shown to lead to a significant improvement in skin hydration and elasticity and to a significant reduction of wrinkle depth [52,53].…”

Section: Discussionmentioning

confidence: 99%

Thermosensitive Hydrogel Mask Significantly Improves Skin Moisture and Skin Tone; Bilateral Clinical Trial

2017

View full text Add to dashboard Cite

Objective: A temperature-sensitive state-changing hydrogel mask was used in this study. Once it comes into contact with the skin and reaches the body temperature, it uniformly and quickly releases the active compounds, which possess moisturizing, anti-oxidant, anti-inflammatory and regenerative properties. Methods: An open label clinical trial was conducted to evaluate the effects of the test product on skin hydration, skin tone and skin ageing. Subjects applied the product to one side of their face and underwent Corneometer ® and Chromameter measurements, Visual assessment of facial skin ageing and facial photography. All assessments and Self-Perception Questionnaires (SPQ) were performed at baseline, after the first application of the test product and after four applications. Results: After a single treatment we observed an increase in skin moisturisation, an improvement of skin tone/luminosity and a reduction in signs of ageing, all statistically significant. After four applications a further improvement in all measured parameters was recorded. These results were confirmed by the subjects' own perceptions, as reported in the SPQ both after one and four applications. Conclusion: The hydrogel mask tested in this study is very effective in improving skin hydration, skin radiance and luminosity, in encouraging an even skin tone and in reducing skin pigmentation.

show abstract

Improvement in skin wrinkles using a preparation containing human growth factors and hyaluronic acid serum

Abstract: Topical application of human growth factor and hyaluronic acid was beneficial in reducing periorbital wrinkles.

Cited by 17 publications

References 9 publications

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

Thermosensitive Hydrogel Mask Significantly Improves Skin Moisture and Skin Tone; Bilateral Clinical Trial

Contact Info

Product

Resources

About