Finding chemical drugs for genetic diseases

Evolutionary and genetic features of drug targets

“…Sun et al. proved the feasibility of this strategy by collecting information from several pioneering studies on orphan diseases, including head and neck squamous‐cell carcinoma and heritable hyperlipidemia …”

“…On the other hand, many human diseases have a genetic component, so genetics can help in differentiating between the causes and consequences of human diseases, which is useful for identifying therapeutic targets . A series of recent studies revealed that successfully targeted genes share certain evolutionary and genetic features . These advances demonstrate that knowledge in modern evolutionary biology and genetics is extremely helpful in identifying potential drug targets, and discovering new drugs as well (Fig.…”

“…21 A series of recent studies revealed that successfully targeted genes share certain evolutionary and genetic features. [23][24][25] These advances demonstrate that knowledge in modern evolutionary biology and genetics is extremely helpful in identifying potential drug targets, and discovering new drugs as well ( Fig. 1).…”

Glucose-6-Phosphate Upregulates Txnip Expression by Interacting With MondoA

“…Here, only the optimized structures were employed for the MM/GBSA calculations because the minimized structures usually give a better results than that based on other MD structures (Xu et al, 2013;Sun et al, 2014a,b). All MM/GBSA calculations were performed with the MMPBSA.py module (Miller et al, 2012) in amber14 using the default parameters (Sun et al, 2013(Sun et al, , 2014. It should be noted that, here, no entropy part was incorporated in the MM/GBSA calculations, and thus the calculated binding free energies seem too large compared with the common-level of the wet experiments (∼-10 kcal/mol).…”

Evolutionary and genetic features of drug targets

“…to escape this predicament, novel concepts should be introduced in this field. A series of recent researches revealed that successfully targeted genes share some common evolutionary and genetic features [1][2][3], which means that the knowledge accumulated in modern evolutionary biology and genetics is very helpful to identify potential drug targets and to find new drugs as well. In this article, we comprehensively summarize the links between human drug targets and genetic diseases and their evolutionary origins, with an attempt to introduce these novel concepts and their medical implications to the biomedical community.…”