A Role for 1α,25-Dihydroxyvitamin D<sub>3</sub> in the Expression of Circadian Genes

Gutierrez‐Monreal, Miguel A.; Duran, Raquel Cuevas-Diaz; Moreno-Cuevas, Jorge E.; Scott, Sean-Patrick

doi:10.1177/0748730414549239

Cited by 33 publications

(29 citation statements)

References 14 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One possible explanation is that the low level of 25OHD present in blood is unable to fully activate the central circadian clock that regulates peripheral circadian clocks, ultimately leading to desychronization of peripheral rhythms [2] with natural day/night cycles. The possible function of vitamin D at the central clock is supported by recent discoveries [4,5]. Besides being present in the kidneys, the enzyme 1α-OHase is found in the human brain and converts 25OHD in the bloodstream to 1,25-dihydroxyvitamin D (1,25OHD), that then activates the VDR [4], which is a ligand transcription factor that regulates gene expression [48], probably including circadian clock genes.…”

Section: Discussionmentioning

confidence: 99%

“…When daily central and peripheral rhythms are chronically disrupted or misaligned, the consequence of these circadian disruptions may be the development of metabolic disease [3]. Recent experimental studies [4,5,6] have suggested that the central circadian clock may also be regulated by another solar zeitgeber, vitamin D. Both 1,25-dihydroxycholecalciferol receptor (VDR) and 1α-hydroxylase (1α-OHase) were found to be widespread in human brain [4]. In adipose-derived stem cells, 1,25-dihydroxycholecalciferol was able to control the expression of circadian clock genes (i.e., BMAL1 and PER2) [5].…”

Section: Introductionmentioning

confidence: 99%

“…Recent experimental studies [4,5,6] have suggested that the central circadian clock may also be regulated by another solar zeitgeber, vitamin D. Both 1,25-dihydroxycholecalciferol receptor (VDR) and 1α-hydroxylase (1α-OHase) were found to be widespread in human brain [4]. In adipose-derived stem cells, 1,25-dihydroxycholecalciferol was able to control the expression of circadian clock genes (i.e., BMAL1 and PER2) [5]. In addition, daily plasma 25-hydroxyvitamin D (25OHD) levels were reported to exhibit circadian oscillation [6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma Vitamin D Deficiency Is Associated With Poor Sleep Quality and Night-Time Eating at Mid-Pregnancy in Singapore

et al. 2017

View full text Add to dashboard Cite

Plasma 25-hydroxyvitamin D (25OHD) deficiency, poor sleep quality, and night-time eating, have been independently associated with adverse pregnancy outcomes, but their inter-relationships are yet to be evaluated. We aimed to investigate the associations between maternal plasma 25OHD status and sleep quality and circadian eating patterns during pregnancy. Data on pregnant women (n = 890) from a prospective cohort (Growing Up in Singapore Towards healthy Outcomes) were analyzed. Plasma 25OHD concentration was measured, while the Pittsburgh sleep quality index (PSQI) and 24-h dietary recall were administered to women at 26–28 weeks’ gestation. Plasma 25OHD status was defined as sufficient (>75 nmol/L), insufficient (50–75 nmol/L), or deficient (<50 nmol/L). Poor sleep quality was defined by a total global PSQI score >5. Predominantly day-time (pDT) and predominantly night-time (pNT) were defined according to consumption of greater proportion of calories (i.e., >50%) from 07:00–18:59 and from 19:00–06:59, respectively. After adjustment for confounders, women with plasma 25OHD deficiency had higher odds of poor sleep quality (odds ratio (OR) 3.49; 95% confidence interval (CI) 1.84–6.63) and pNT eating (OR: 1.85; 95% CI 1.00–3.41) than those who were 25OHD sufficient. Our findings show the association of maternal plasma 25OHD deficiency with poor sleep quality and pNT eating at mid-pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma Vitamin D Deficiency Is Associated With Poor Sleep Quality and Night-Time Eating at Mid-Pregnancy in Singapore

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Moreover, 1,25-(OH) 2 D 3 modulates the expression of circadian genes in stem cells derived from adipose tissue (ADSCs), causing the synchronization of BMAL1 and PER2 genes [67], indicating an essential role of vitamin D3 in the control of molecular clocks, which in turn are essential in positioning cellular homeostasis along the subtle line that separates normal or pathologic/neoplastic growth. 1,25-(OH) 2 D 3 cooperates with BRCA1 playing an essential role in the acetylation of the promoter of p21WAF1 and inhibition of cancer cells and cancer stem cells of the breast [68].…”

Section: Vitamin D3mentioning

confidence: 99%

Cancer Stem Cells: Foe or Reprogrammable Cells for Efficient Cancer Therapy?

Ventura¹,

Olivi²,

Cavallini³

et al. 2015

NanoWorld J

View full text Add to dashboard Cite

Embryonic development and carcinogenesis share many molecular pathways and regulatory molecules. While the induction of a pluripotent state involves a significant oncogenic risk, as in induced pluripotent stem cells (iPSCs), the embryonic environment in vivo has been shown to suppress tumor development. In this review, we discuss the subtle equilibrium between the nanotopography (niche) of the hosting tissue resident stem cells and their biological dynamics, including the transformation in cancer stem cells. We review consistent findings indicating the potential for modulating the biology of human cancer stem cells by the aid of naturally occurring or synthetic molecules, including developmental stage zebrafish embryo extracts, hyaluronan, butyric acid (BA) and retinoic acid (RA), hyaluronan mixed esters of BA and RA, melatonin, vitamin D3, and endorphin peptides. Within this context, we dissect the multifaceted mechanisms orchestrated by endorphinergic systems, including paracrine cellto-cell communication, as well as the establishment of autocrine and intracrine (intracellular) peptide actions driving transcriptional responses and self-sustaining loops that behave as long-lived signals imparting features characteristic of differentiation, growth regulation and cell memory.Based upon the remarkable action of electromagnetic fields and mechanical vibration on (stem) cell signaling, differentiation, and senescence, we also consider the potential for using these physical energies as a tool to afford a fine tuning of cancer stem cell fate.On the whole, we forecast future deployment of the physical and/or chemical approaches described herein aiming at reprogramming, rather than destroying cancer stem cells, eventually placing cancer therapy within the context of Regenerative Medicine.

show abstract

“…From a therapeutic viewpoint, several lessons emerge from the study by Wu et al . Notably, there is a growing body of evidence to suggest that VDR activation has a regulatory role in the circadian clock-based intrinsic time-keeping system,14 15 which in turn is thought to influence mutualistic host–microbiota interactions 16. Furthermore, diurnal fluctuations of the active form of vitamin D (namely 1,25-dihydroxyvitamin D) have been reported 17.…”

mentioning

confidence: 99%