Second messengers mediating the proliferation and collagen synthesis of tenocytes induced by low-level laser irradiation

Chen, Mei-Hsiu; Huang, Yun Chien; Sun, Jui Sheng; Chao, Yuan-Hung; Chen, Ming Hong

doi:10.1007/s10103-014-1658-5

Cited by 26 publications

(46 citation statements)

References 31 publications

(35 reference statements)

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“…23 Moreover, LILT increases the production of intracellular secondary messengers, such as ATP and calcium ion (Ca 2+ ). Additionally, it can mediate the proliferation of tenocytes and collagen synthesis, 24 which prevents oxidative stress and reduces tendon fibrosis. 25 Through these mechanisms, it can accelerate tendon healing and alleviate tendinous inflammation and pain.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Efficacy Comparison of High-Intensity and Low-Intensity Laser Therapy in the Treatment of Lateral Epicondylitis: A Randomized Double-Blind Clinical Study

et al. 2020

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Objectives: This study aims to evaluate and compare the short-term efficacies of high-intensity laser therapy (HILT) and low-intensity laser therapy (LILT) in the treatment of lateral epicondylitis (LE). Patients and methods: Sixty patients (16 males, 44 females; mean age 44.2±9.3 years; range, 18 to 65 years) with unilateral elbow pain were randomized into two groups as 30 patients treated with HILT (9 males and 21 females) and 30 patients treated with LILT (7 males and 23 females). The HILT (1,064 nm) and LILT (904 nm) were administered three times a week for three weeks, and each treatment was combined with an epicondylitis bandage. A visual analog scale (VAS), quick Disabilities of the Arm, Shoulder, and Hand (QDASH) questionnaire, Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36), and hand grip strength test were used to evaluate the patients before and three weeks after treatment. Results: The two groups had similar demographic characteristics, including age, sex, occupation, and body mass index (p>0.05). There were no statistically significant differences between the two groups in terms of the pretreatment VAS, QDASH, hand grip strength, and SF-36 scores (p>0.05). After three weeks, both groups showed significant improvements in all of the parameters (p<0.05). However, in the HILT group, the QDASH, hand grip strength, and SF-36 physical component summary (PCS) scores showed superior improvement compared to the LILT group (p<0.05). Conclusion: Each treatment modality was found to be effective and safe for the short-term treatment of LE. However, the HILT exhibited more significant effects on the hand grip strength, QDASH, and SF-36 PCS scores than the LILT.

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Section: Discussionmentioning

confidence: 99%

Short-Term Efficacy Comparison of High-Intensity and Low-Intensity Laser Therapy in the Treatment of Lateral Epicondylitis: A Randomized Double-Blind Clinical Study

et al. 2020

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“…Furthermore, it has been reported that TGF-β could induce BMP expression [28]. BMPs belong to the TGF-β superfamily and play an important role in embryonic development and bone formation [29].…”

Section: Discussionmentioning

confidence: 99%

Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis

et al. 2015

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This study evaluated the morphological changes produced by LLLT on the initial stages of bone healing and also studied the pathways that stimulate the expression of genes related to bone cell proliferation and differentiation. One hundred Wistar rats were divided into control and treated groups. Noncritical size bone defects were surgically created at the upper third of the tibia. Laser irradiation (Ga-Al-As laser 830 nm, 30 mW, 94 s, 2.8 J) was performed for 1, 2, 3, 5, and 7 sessions. Histopathology revealed that treated animals produced increased amount of newly formed bone at the site of the injury. Moreover, microarray analysis evidenced that LLLT produced a significant increase in the expression TGF-β, BMP, FGF, and RUNX-2 that could stimulate osteoblast proliferation and differentiation, which may be related to improving the deposition of newly formed bone at the site of the injury. Thus, it is possible to conclude that LLLT improves bone healing by producing a significant increase in the expression of osteogenic genes.

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“…Recent findings provide important new insight. PBM can transiently increase the [Ca 2+ ]i in cardiomyocytes and stimulate it in tenocyte cells as well as in Paramecium and higher fluence at higher power affects its swimming behavior . Moreover, effects on [Ca 2+ ]i have been reported by Friedman and Lubart in mammalian cells.…”

Section: Introductionmentioning

confidence: 92%

Photobiomodulation by Infrared Diode Laser: Effects on Intracellular Calcium Concentration and Nitric Oxide Production of Paramecium

Amaroli

Benedicenti

Ferrando

et al. 2016

Photochem & Photobiology

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In Paramecium, cilia beating is correlated to intracellular calcium concentration ([Ca ]i) and nitric oxide (NO) synthesis. Recent findings affirm that photobiomodulation (PBM) can transiently increase the [Ca ]i in mammalian cells. In this study, we investigated the effect of both 808 and 980 nm diode laser irradiated with flat-top hand-piece on [Ca ]i and NO production of Paramecium primaurelia, to provide basic information for the development of new therapeutic approaches. In the experiments, the laser power in CW varied (0.1; 0.5; 1; and 1.5 W) to generate the following respective fluences: 6.4; 32; 64; and 96 J cm . The 6.4 J cm did not induce PBM if irradiated by both 808 and 980 nm diode laser. Conversely, the 32 J cm fluence had no effect on Paramecium cells if irradiated by the 808 nm laser, while if irradiated by the 980 nm laser induced increment in swimming speed (suggesting an effect on the [Ca ]i, NO production, similar to the 64 J cm with the 808 nm wavelength). The more evident discordance occurred with the 96 J cm fluence, which had the more efficient effect on PBM among the parameters if irradiated with the 808 nm laser and killed the Paramecium cells if irradiated by the 980 nm laser. Lastly, the 980 nm and 64 or 96 J cm were the only parameters to induce a release of stored calcium.

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Second messengers mediating the proliferation and collagen synthesis of tenocytes induced by low-level laser irradiation

Cited by 26 publications

References 31 publications

Short-Term Efficacy Comparison of High-Intensity and Low-Intensity Laser Therapy in the Treatment of Lateral Epicondylitis: A Randomized Double-Blind Clinical Study

Short-Term Efficacy Comparison of High-Intensity and Low-Intensity Laser Therapy in the Treatment of Lateral Epicondylitis: A Randomized Double-Blind Clinical Study

Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis

Photobiomodulation by Infrared Diode Laser: Effects on Intracellular Calcium Concentration and Nitric Oxide Production of Paramecium

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