Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats

Song, Xiaofeng; Liu, Jia; Cui, Wei; Zhang, Meng; Chen, Wensheng; Yuan, Zuyi; Guo, Jing; Li, Huihua; Zhu, Guo‐Qing; Líu, Hao; Kang, Yu-Ming

doi:10.1016/j.taap.2014.09.004

Cited by 53 publications

(45 citation statements)

References 37 publications

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“…Blood pressure was measured by a tail-cuff occlusion method as described previously (Song et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

“…Immunohistochemical labeling was performed as described previously (Kang et al, 2006;Kang et al, 2009b;Song et al, 2014) to stain Fra-like protein (Fra-LI, a marker of chronic neuronal activation; sc-253, Santa Cruz Biotechnology). Fra-LI-positive neurons within a window superimposed over the dorsal parvocellular (dpPVN), ventrolateral parvocellular (vlpPVN) and magnocellular (mPVN) subregions of the PVN were counted for data analysis.…”

Section: Methodsmentioning

confidence: 99%

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Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress

Zhang

Liu

et al. 2015

Toxicology and Applied Pharmacology

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“…Blood pressure was measured by a tail-cuff occlusion method as described previously (Song et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress

Zhang

Liu

et al. 2015

Toxicology and Applied Pharmacology

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“…52 The prohypertensive role of tumor necrosis factor-α-mediated inflammation has been shown in several studies that inhibited this cytokine with a tumor necrosis factor-α receptor fusion protein bound to the cristallisable fragment of IgG (etanercept). [53][54][55] Participation of the adaptive immunity in hypertension was also shown in the studies of Vinh et al 56 that examined the effects of suppressing the costimulation required for antigen-induced T cell activation and demonstrated that mice lacking B7 ligands or treated with CTLA4 (Abatacept) to block T cell costimulation showed inhibited cytokine production, reduced of vascular T cell accumulation and resistance to angiotensin-induced hypertension.…”

Section: Innate and Adaptive Immunity In The Pathogenesis Of Hypertenmentioning

confidence: 83%

Autoimmunity in the Pathogenesis of Hypertension

Rodríguez‐Iturbe

2016

Hypertension

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“…The bilateral PVN injections were completed within 1 min, and the microinjection volume for each side was 1 lL. [9,11].…”

Section: General Experimental Protocolmentioning

confidence: 99%

“…Although the PICs in the PVN have been proved to be involved in sympathoexcitation and hypertensive response [9], the mechanism by which PICs modulate oxidative stress in the PVN and contribute to sympathoexcitation in salt-sensitive hypertension is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Targeting Interleukin-1 beta to Suppress Sympathoexcitation in Hypothalamic Paraventricular Nucleus in Dahl Salt-Sensitive Hypertensive Rats

Zhao

et al. 2015

Cardiovasc Toxicol

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Findings from our laboratory indicate that expressions of some proinflammatory cytokines such as tumor necrosis factor, interleukin-6 and oxidative stress responses are increased in the hypothalamic paraventricular nucleus (PVN) and contribute to the progression of salt-sensitive hypertension. In this study, we determined whether interleukin-1 beta (IL-1β) activation within the PVN contributes to sympathoexcitation during development of salt-dependent hypertension. Eight-week-old male Dahl salt-sensitive (S) rats received a high-salt diet (HS, 8 % NaCl) or a normal-salt diet (NS, 0.3 % NaCl) for 6 weeks, and all rats were treated with bilateral PVN injection of gevokizumab (IL-1β inhibitor, 1 μL of 10 μg) or vehicle once a week. The mean arterial pressure (MAP), heart rate (HR) and plasma norepinephrine (NE) were significantly increased in high-salt-fed rats. In addition, rats with high-salt diet had higher levels of NOX-2, NOX-4 [subunits of NAD (P) H oxidase], IL-1β, NLRP3 (NOD-like receptor family pyrin domain containing 3), Fra-LI (an indicator of chronic neuronal activation) and lower levels of IL-10 in the PVN than normal-diet rats. Bilateral PVN injection of gevokizumab decreased MAP, HR and NE, attenuated the levels of oxidative stress and restored the balance of cytokines. These findings suggest that IL-1β activation in the PVN plays a role in salt-sensitive hypertension.

show abstract

Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats

Cited by 53 publications

References 37 publications

Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress

Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress

Autoimmunity in the Pathogenesis of Hypertension

Targeting Interleukin-1 beta to Suppress Sympathoexcitation in Hypothalamic Paraventricular Nucleus in Dahl Salt-Sensitive Hypertensive Rats

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