“…These subtypes comprised mostly OSCCs and had an overrepresentation of female patients, matching the clinical description of elusive atypical HNSCC (Chaturvedi et al, 2013, Toner and O'Regan, 2009, MacKenzie et al, 2000, Patel et al, 2011, Koch et al, 1999, Koo et al, 2013, Brown et al, 2012, Montero et al, 2012, Perry et al, 2015). Epidemiological evidence indicates that smoking is less of a risk factor for OSCC than it is for LSCC (Maasland et al, 2014, Maasland et al, 2015). Consistent with this, we have found that LSCCs are primarily (though not exclusively) found in the smoking-related MethylMix subsets, while OSCCs are more heterogeneous and can be smoking-related, HPV-related, or atypical.…”