Antidepressant treatment for postnatal depression

Molyneaux, Emma; Howard, Louise M.; McGeown, Helen; Karia, Amar M.; Trevillion, Kylee

doi:10.1002/14651858.cd002018.pub2

Cited by 97 publications

(48 citation statements)

References 64 publications

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“…Caution is therefore warranted. There is no strong evidence that favors the superiority of antidepressive drug treatment over psychotherapy [2,5]. In our opinion, psychotherapy is the first line treatment for mild to moderate depression in pregnant or breastfeeding WWE.…”

Section: Recommendations For Peripartum Depression In Wwementioning

confidence: 90%

“…A recent Cochrane review regarding treatment for moderate postnatal depression in women without epilepsy favored selective serotonin re-uptake inhibitors (SSRIs) over placebo in terms of response and remission rates [2]. Maternal side effects were frequently reported.…”

Section: Antidepressive Medicationmentioning

confidence: 99%

“…There was insufficient evidence to conclude whether antidepressant or psychosocial treatments were more effective. There were little data on potential effects on the motherchild relationship [2].…”

Section: Antidepressive Medicationmentioning

confidence: 99%

“…Antidepressants are lipid soluble and excreted in breast milk [2], but the degree of exposure for the child is considerably lower than in utero. Some case reports have described adverse events such as sedation, poor feeding and disturbed sleep.…”

Section: Antidepressants and Breastfeedingmentioning

confidence: 99%

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Depression and anxiety during pregnancy and the postpartum period in women with epilepsy: A review of frequency, risks and recommendations for treatment

Bjørk

Veiby

Engelsen

et al. 2015

Seizure

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Peripartum depression is frequent in WWE and seldom medically treated. Health personnel should screen WWE for psychiatric disease and risk factors during pre-pregnancy planning, pregnancy and postpartum follow up. Treatment decisions should rely on efficacy and safety data in peripartum patients without epilepsy and non-pregnant people with epilepsy. Consequences of in utero exposure to AED therapy in combination with antidepressants are not known, and non-pharmacological treatment should be tried first.

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Section: Recommendations For Peripartum Depression In Wwementioning

confidence: 90%

Section: Antidepressive Medicationmentioning

confidence: 99%

Section: Antidepressive Medicationmentioning

confidence: 99%

Section: Antidepressants and Breastfeedingmentioning

confidence: 99%

See 2 more Smart Citations

Depression and anxiety during pregnancy and the postpartum period in women with epilepsy: A review of frequency, risks and recommendations for treatment

Bjørk

Veiby

Engelsen

et al. 2015

Seizure

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“…Nortriptyline is second-generation TCA and is mainly used in the treatment of major depression and childhood nocturnal enuresis [3]. Additionally, although nortriptyline has been shown to have fewer side effects than tertiary amine TCAs, such as amitriptyline, imipramine, and clomipramine, some side effects, including dry mouth, sedation, constipation, mild blurred vision, tinnitus, euphoria, and mania, have still been observed [4].…”

Section: Introductionmentioning

confidence: 99%

Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent K⁺channels in coronary arterial smooth muscle cells

Shin

Kim

et al. 2017

Korean J Physiol Pharmacol

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We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC50 value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. Although application of nortriptyline did not change the activation curve, nortriptyline shifted the inactivation current toward a more negative potential. Application of train pulses (1 or 2 Hz) did not change the nortriptyline-induced Kv channel inhibition, suggesting that the effects of nortiprtyline were not use-dependent. Preincubation with the Kv1.5 and Kv2.1/2.2 inhibitors, DPO-1 and guangxitoxin did not affect nortriptyline inhibition of Kv channels. From these results, we concluded that nortriptyline inhibited Kv channels in a concentration-dependent and state-independent manner independently of serotonin reuptake.

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