Specific Genetic Influences on Nighttime Blood Pressure

Xu, Xiaojing; Su, Shaoyong; Treiber, Frank A.; Vlietinck, Robert; Fagard, Robert; Derom, Cathérine; Gielen, Marij; Loos, Ruth J.F.; Snieder, Harold; Wang, Xiaoling

doi:10.1093/ajh/hpu162

Cited by 12 publications

(9 citation statements)

References 10 publications

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“…To what extent shared genetic and environmental factors may contribute to the association between sleep behavior and BP has not been reported. In our recent two studies on ambulatory blood pressure in youth [59] and young adult [60], we observed that nighttime BP not only shared genes with daytime BP but a sizeable part was explained by its own specific genetic determinants. This indicates that the underlying mechanisms for BP regulation partly change with the day-night shift, either via switching on or off of relevant genes or via a change in the amplitude of their expression.…”

Section: Influence Of Other Family Risk Factors On Familial Aggregatimentioning

confidence: 99%

Familial Aggregation and Childhood Blood Pressure

Wang

et al. 2014

Curr Hypertens Rep

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There is growing concern about elevated blood pressure (BP) in children. The evidence for familial aggregation of childhood BP is substantial. Twin studies have shown that a large part of the familial aggregation of childhood BP is due to genes. The first part of this review provides the latest progress in gene finding for childhood BP, focusing on the combined effects of multiple loci identified from the genome-wide association studies on adult BP. We further review the evidence on the contribution of the genetic components of other family risk factors to the familial aggregation of childhood BP including obesity, birth weight, sleep quality, sodium intake, parental smoking, and socioeconomic status. At the end, we emphasize the promise of using genomic-relatedness-matrix restricted maximum likelihood (GREML) analysis, a method that uses genome-wide data from unrelated individuals, in answering a number of unsolved questions in the familial aggregation of childhood BP.

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Section: Influence Of Other Family Risk Factors On Familial Aggregatimentioning

confidence: 99%

Familial Aggregation and Childhood Blood Pressure

Wang

et al. 2014

Curr Hypertens Rep

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“…Xu et al . [46] explored the genetic regulation of BP and found that nighttime BP has specific genetic determinants. Although we reviewed no study about ambulatory HRV in our meta-analysis, a recent study reported that autonomic nervous system alterations during sleep may be present a long time before the onset of a cardiovascular event in individuals with cardiovascular risks [47].…”

Section: Discussionmentioning

confidence: 99%

Influence of family history of hypertension on blood pressure and heart rate variability in young adults: a meta-analysis

Queiroz¹,

Prado²,

Alves-Santos

et al. 2022

Blood Pressure Monitoring

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Purpouse This meta-analysis evaluates the impact of family history of hypertension (FHH+) on blood pressure (BP) and heart rate variability (HRV) in young adults. Methods Observational studies that evaluated adults (aged between 18 and 40 years) of both sexes, are without cardiometabolic disease diagnosis, are published in English, and are reporting on the influence of FHH+ (father, mother, or both) on BP and HRV were included. In June 2021, we made a search of the electronic database MEDLINE (accessed by PubMed). Random-effects models were used, and data are reported as standardized mean difference and 95% confidence limits. Results Thirty-eight studies with a total of 2025 individuals were included. Clinic systolic [3.13 mmHg (1.75–4.51)] and diastolic [2.85 mmHg (1.65–4.04)] BPs were higher (P < 0.001) in individuals with an FHH+. Only 24-h systolic BP was higher [1.76 mmHg (0.05–3.47); P = 0.04] in individuals with an FHH+. As for HRV indices in time-domain, RMSSD: −7.00 ms (−10.75 to −3.26), SDNN: −13.93 ms (−23.56 to −4.30), and HF [−6.82 n. u. (−9.76 to −3.89)] were lower (P < 0.05), and LF [4.78 ms (2.52–7.03)] and LF/HF ratio [0.32 (0.14–0.50)] were higher (P < 0.001) in individuals with an FHH+. Conclusion FHH+ negatively impacts BP and HRV in young adults.

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“…In addition, in the current study, genetic correlations with obesity indices seemed to be lower for daytime BP than for sleeping BP but no differences were found between SBP and DBP. This might possibly be because of partly different genes regulating daytime and night-time BP [ 30 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study

Man

Nolte

Jaju

et al. 2020

Journal of Hypertension

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Objective: To more precisely and comprehensively estimate the genetic and environmental correlations between various indices of obesity and BP. Methods: We estimated heritability and genetic correlations of obesity indices with BP in the Oman family study ( n = 1231). Ambulatory and office beat-to-beat BP was measured and mean values for SBP and DBP during daytime, sleep, 24-h and 10 min at rest were calculated. Different indices were used to quantify obesity and fat distribution: BMI, percentage of body fat (%BF), waist circumference and waist-to-height ratio (WHtR). SOLAR software was used to perform univariate and bivariate quantitative genetic analyses adjusting for age, age 2 , sex, age-sex and age 2 -sex interactions. Results: Heritabilities of BP ranged from 30.2 to 38.2% for ambulatory daytime, 16.8–21.4% for sleeping time, 32.1–40.4% for 24-h and 22–24.4% for office beat-to-beat measurements. Heritabilities for obesity indices were 67.8% for BMI, 52.2% for %BF, 37.3% for waist circumference and 37.9% for WHtR. All obesity measures had consistently positive phenotypic correlations with ambulatory and office beat-to-beat SBP and DBP ( r -range: 0.14–0.32). Genetic correlations of obesity indices with SBP and DBP were higher than environmental correlations ( r G : 0.16–0.50; r E : 0.01–0.31). Conclusion: The considerable genetic overlap between a variety of obesity indices and both ambulatory and office beat-to-beat BP highlights the relevance of pleiotropic genes. Future GWAS analyses should discover the specific genes both influencing obesity indices and BP to help unravel their shared genetic background.

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Specific Genetic Influences on Nighttime Blood Pressure

Abstract: In addition to genes that influence both daytime and nighttime BP, a large part of the heritability is explained by genes that specifically influence BP at night.

Cited by 12 publications

References 10 publications

Familial Aggregation and Childhood Blood Pressure

Familial Aggregation and Childhood Blood Pressure

Influence of family history of hypertension on blood pressure and heart rate variability in young adults: a meta-analysis

Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study

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