Reward pathway dysfunction in gambling disorder: A meta-analysis of functional magnetic resonance imaging studies

Meng, Yajing; Deng, Wei; Wang, Hui-yao; Guo, Wanjun; Li, Tao; Lam, Chaw; Xia, Lin

doi:10.1016/j.bbr.2014.08.057

Cited by 38 publications

(28 citation statements)

References 54 publications

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“…delay discounting) in gamblers more than less salient gambling cues did (Miedl et al 2014). In addition, fMRI studies investigating cue reactivity responses towards gambling cues in problematic gamblers have shown enhanced BOLD responses in the mesolimbic prefrontal regions Meng et al 2014b), quite similar as findings in subjects with substance use disorders. The important message from these fMRI studies is that naturalistic gambling cues critically influence the behavioural and fMRI results in disordered gambling studies.…”

Section: Neurobiology Of Disordered Gamblingmentioning

confidence: 92%

Behavioural addiction—A rising tide?

Chamberlain

Löchner

Stein

et al. 2016

European Neuropsychopharmacology

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The term 'addiction' was traditionally used in relation to centrally active substances, such as cocaine, alcohol, or nicotine. Addiction is not a unitary construct but rather incorporates a number of features, such as repetitive engagement in behaviours that are rewarding (at least initially), loss of control (spiralling engagement over time), persistence despite untoward functional consequences, and physical dependence (evidenced by withdrawal symptoms when intake of the substance diminishes). It has been suggested that certain psychiatric disorders characterized by maladaptive, repetitive behaviours share parallels with substance addiction and therefore represent 'behavioural addictions'. This perspective has influenced the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), which now has a category 'Substance Related and Addictive Disorders', including gambling disorder. Could other disorders characterised by repetitive behaviours, besides gambling disorder, also be considered 'addictions'? Potential examples include kleptomania, compulsive sexual behaviour, 'Internet addiction', trichotillomania (hair pulling disorder), and skin-picking disorder. This paper seeks to define what is meant by 'behavioural addiction', and critically considers the evidence for and against this conceptualisation in respect of the above conditions, from perspectives of aetiology, phenomenology, co-morbidity, neurobiology, and treatment. Research in this area has important implications for future diagnostic classification systems, neurobiological models, and novel treatment directions.

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Section: Neurobiology Of Disordered Gamblingmentioning

confidence: 92%

Behavioural addiction—A rising tide?

Chamberlain

Löchner

Stein

et al. 2016

European Neuropsychopharmacology

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“…A recent meta‐analysis of fMRI cue‐reactivity studies in PG assessed 62 candidate studies, of which 13 eventually met the selection criteria (Meng et al . ). The researchers observed increased activation in the right lentiform nucleus (putamen and globus pallidus) and the left middle occipital gyrus across the selected studies.…”

Section: Cognitive and Neurobiological Changesmentioning

confidence: 97%

Pathological gambling: a review of the neurobiological evidence relevant for its classification as an addictive disorder

2016

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In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of “Pathological Gambling” (“PG”). Some academic opinion favors leaving “PG” in the “Impulse Control Disorder” (“ICD”) category, as in ICD-10, whereas others argue that new data especially from the neurobiological area favor allocating it to the category of “Substance-related and Addictive Disorders” (“SADs”), following the decision in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders. The current review examines important findings in relation to “PG”, with the aim of enabling a well-informed decision to be made with respect to the classification of “PG” as a “SAD” or “ICD” in ICD-11. Particular attention is given to cognitive deficits and underlying neurobiological mechanisms that play a role in “SADs” and “ICDs”. These processes are impulsivity, compulsivity, reward/punishment processing and decision making. In summary, the strongest arguments for subsuming “PG” under a larger “SAD” category relate to the existence of similar diagnostic characteristics; the high co-morbidity rates between the disorders; their common core features including reward-related aspects (positive reinforcement: behaviors are pleasurable at the beginning which is not the case for “ICDs”); the findings that the same brain structures are involved in “PG” and “SADs”, including the ventral striatum. Research on compulsivity suggests a relationship with “PG” and “SAD”, particularly in later stages of the disorders. Although research is limited for “ICDs”, current data do not support continuing to classify “PG” as an “ICD”.

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“…Functional MRI studies using cue-reactivity procedures have revealed increased responsiveness in these circuits and brain areas related to attentional processing toward gambling stimuli in disordered gamblers compared to controls (Crockford et al, 2005;Goudriaan et al, 2010;Kober et al, 2016). Furthermore, a recent meta-analysis of 13 fMRI cuereactivity studies reported increased activation in the lentiform nucleus (putamen and globus pallidus) in individuals with GD compared to controls, after controlling for the presence of SUDs (Meng et al, 2014). However, an early study using auditory descriptions of gambling scenarios reported decreased response in medial PFC (mPFC) and ACC in men with GD (Potenza et al, 2003).…”

Section: Cue-induced Craving In Gdmentioning

confidence: 99%

Neural correlates of cue‐ and stress‐induced craving in gambling disorders: implications for transcranial magnetic stimulation interventions

Spagnolo

Pérez²,

Terraneo³

et al. 2019

Eur J of Neuroscience

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Gambling disorder (GD), currently considered a behavioral addiction, shows substantial similarities with substance use disorders (SUDs) in terms of neurobiology and phenomenology. These similarities have been recognized in the DSM‐5, although several relevant differences still exist in the diagnostic criteria, in particular, with regard to the role of cue‐ and stress‐ induced craving. Craving, recently included as a new criterion for SUDs diagnosis only, is a key construct also in the pathophysiology of GD. Furthermore, brain imaging studies indicate that similar alterations in cortico‐limbic‐striatal and prefrontal control circuits underlie the emergence of craving states in both disorders. This has important implications for the identification of neurobiologically based anti‐craving interventions, which may be used for both GD and SUDs. In this regard, a novel neuromodulation intervention, named repetitive transcranial magnetic stimulation (rTMS), is emerging as a promising treatment for craving in SUDs, and could potentially be effective also in treating gambling urges. Here, we review the clinical neurobiological research on GD, with a specific emphasis on the neural circuits implicated in cue‐ and stress‐craving, taking SUDs as the major comparative example. Furthermore, we describe the studies that have evaluated rTMS as a therapeutic tool for targeting and restoring the neural alterations underlying gambling urge. The manuscript concludes discussing some of the limitations of the current studies, and suggests directions for future rTMS research in GD.

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Reward pathway dysfunction in gambling disorder: A meta-analysis of functional magnetic resonance imaging studies

Cited by 38 publications

References 54 publications

Behavioural addiction—A rising tide?

Behavioural addiction—A rising tide?

Pathological gambling: a review of the neurobiological evidence relevant for its classification as an addictive disorder

Neural correlates of cue‐ and stress‐induced craving in gambling disorders: implications for transcranial magnetic stimulation interventions

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