Neuroimaging of Plasmacytoma

Agarwal, Ajay

doi:10.15274/nrj-2014-10078

Cited by 28 publications

(30 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our patient performed MRI (an investigation generally performed after nasal endoscopy to evaluate the invasiveness and aggressiveness of the mass) that did not evidence typical signs of cancer, such as bone erosion (16) or infiltration of close structures (12).…”

Section: Discussionmentioning

confidence: 99%

Extramedullary nasal plasmacytoma arising after polyp excision and the role of the inflammation in tumor development: A case report

et al. 2020

View full text Add to dashboard Cite

A correlation between inflammation and cancer has been identified in the case of nasal cancer, however a specific connection between nasal inflammation and extramedullary nasal plasmacytoma (ENP), to the best of our knowledge, has not yet been determined. The present case report describes a patient affected by ENP, in who the tumor arose in the same area, from which a nasal polyp was previously surgically removed, five months after the polyp excision. The patient underwent surgical endoscopic tumor asportation without being treated with radio-chemotherapy. ENP was totally removed via surgery and no signs of recurrence were identified by endoscopy or magnetic resonance imaging during the last checkup 1 year after tumor asportation. It was hypothesized that in this elderly patient, who was exposed to viral infections and pollution for several years, ENP may be correlated to the inflammatory process that occurred after surgery, and this likely contributed to a neoplastic mutation in B-cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Extramedullary nasal plasmacytoma arising after polyp excision and the role of the inflammation in tumor development: A case report

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although the extent of novel drugs crossing the blood brain barrier is not clear, bortezomib has the promise to improve the clinical outcomes. [ 10 , 11 , 13 ]…”

Section: Discussionmentioning

confidence: 99%

Multiple myeloma with pathologically proven skull plasmacytoma after a mild head injury

Yang

Zheng

et al. 2018

Medicine

View full text Add to dashboard Cite

Rationale:MM is a malignant tumor originating from the plasma cells of the bone marrow. Central nervous system myelomatosis is very rare and may be a complication of MM.Patient concerns:A 60-year-old man presented with a slowly growing soft mass at his right frontal scalp after a mild head injury 6 months ago.Diagnoses:Neuroradiological examinations revealed a solid intracranial-extracranial mass with an osteolytic lesion in the skull. Histopathological examination showed skull plasmacytoma, and postoperative examinations revealed multiple myeloma.Interventions:The tumor was completely removed and the skull defect repaired with the titanium mesh. Then, chemotherapy was initiated after surgery with bortezomib and dexamethasone.Outcomes:The patient received eight chemotherapies within one year after surgery.Lessons:Despite a history of head injury, a differential diagnosis should be kept in mind during the diagnosis of solid intracranial-extracranial masses, especially in the presence of osteolytic skull at the lesioned site.

show abstract

“…EMP is a rare plasma cell neoplasm which involves soft tissues, without systemic involvement. It most frequently occurs in the upper respiratory tract and oral cavity (Table 2 ) [ 2 , 4 , 5 , 7 , 10 ]. Since EMP can have different clinical and therapeutic features, the diagnosis of EMP and the choice of the treatment should be discussed by a multidisciplinary cancer board including an otolaryngologist, an oncohematologist, a pathologist, and a radiotherapist.…”

Section: Discussionmentioning

confidence: 99%

“…Plasmacytoma is a malignant neoplasm of monoclonal B cells first described by Schridde in 1905 [ 1 ]. It consists of three distinct entities according to the International Myeloma Working Group, 2003: solitary plasmacytoma of bone (SPB), extramedullary plasmacytoma (EMP), and multiple primary or recurrent plasmacytomas (Table 1 ) [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Strategy for the treatment and follow-up of sinonasal solitary extramedullary plasmacytoma: a case series

et al. 2017

View full text Add to dashboard Cite

BackgroundExtramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells outside bone marrow. It accounts for 4% of all non-epithelial sinonasal tumors. According to the literature, radiotherapy is the standard therapy for extramedullary plasmacytoma. However, the conversion rate of extramedullary plasmacytoma to multiple myeloma is reported to be between 11 and 33% over 10 years. The highest risk of conversion is reported during the first 2 years after diagnosis, but conversion has been noted up to 15 years after diagnosis. Once conversion to multiple myeloma is complete, less than 10% of patients will survive 10 years.Case presentationWe present three cases of sinonasal extramedullary plasmacytoma who underwent radiotherapy: a 61-year-old white man, a 60-year-old white man, and a 37-year-old white woman. We found long-term survival with stable disease in all three cases.ConclusionsThe management of solitary extramedullary plasmacytomas of the sinonasal tract is not well established yet. However, the possibility of recurrence and progression to multiple myeloma requires a thorough follow-up protocol. Due to the absence of a standardized protocol for these tumors, we tried to design a tailored long-term follow-up scheme.

show abstract

Neuroimaging of Plasmacytoma

Abstract: SUMMARY -This pictorial review describes the spectrum of CT/MR imaging findings

Cited by 28 publications

References 3 publications

Extramedullary nasal plasmacytoma arising after polyp excision and the role of the inflammation in tumor development: A case report

Extramedullary nasal plasmacytoma arising after polyp excision and the role of the inflammation in tumor development: A case report

Multiple myeloma with pathologically proven skull plasmacytoma after a mild head injury

Strategy for the treatment and follow-up of sinonasal solitary extramedullary plasmacytoma: a case series

Contact Info

Product

Resources

About