Safety and completion of a 4-month course of rifampicin for latent tuberculous infection in children

Cruz, Andrea T.; Starke, Jeffrey R.

doi:10.5588/ijtld.14.0286

Cited by 30 publications

(25 citation statements)

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“…A total of 23 publications related to RCTs and 55 related to nonrandomized studies were included. A flow diagram documenting the process of study selection is provided in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…Data from nonrandomized studies found that the highest median rate of withdrawals from adverse events was associated with INH‐6 (median 5.8%, range 2.3%‐24.5%; 9 studies), followed by INH/RPT‐3 (median 4.3%, range 1.3%‐8.4%; 7 studies), INH‐9 (median 2.6%, range 0.4%‐26.8%; 13 studies), INH/RMP 3‐4 (median 1.8%, range 0.5%‐5.1%; 4 studies), and RMP 3‐4 (median 0%, range 0%‐5.2%; 6 studies).…”

Section: Resultsmentioning

confidence: 99%

“…Three RCTs and 4 nonrandomized studies reported on adverse events in children . Results from these studies are reported in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Data from nonrandomized studies found that the highest median rate of withdrawals from adverse events was associated with INH-6 (median 5.8%, range 2.3%-24.5%; 9 studies 45,51,52,56,58,66,70,72,79 ), followed by INH/RPT-3 (median 4.3%, range 1.3%-8.4%; 7 studies 36,37,43,83,84,86,88 ), INH-9 (median 2.6%, range 0.4%-26.8%; 13 studies [41][42][43]48,49,54,57,62,65,67,77,86,88 ), INH/RMP 3-4 (median 1.8%, range 0.5%-5.1%; 4 studies 45,54,56,81 ), and RMP 3-4 (median 0%, range 0%-5.2%; 6 studies 36,45,48,49,57,58 ). 6 Severe reactions were those of grade 4 severity or associated with hypotension, anaphylaxis, loss of consciousness, or hospitalization.…”

Section: Total and Grade 3 To 4 Adverse Events And Adverse Event-rementioning

confidence: 99%

See 3 more Smart Citations

A systematic review of adverse events of rifapentine and isoniazid compared to other treatments for latent tuberculosis infection

Pease

Hutton

Yazdi

et al. 2018

Pharmacoepidemiology and Drug

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“…A total of 23 publications related to RCTs and 55 related to nonrandomized studies were included. A flow diagram documenting the process of study selection is provided in Figure .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Three RCTs and 4 nonrandomized studies reported on adverse events in children . Results from these studies are reported in Table .…”

Section: Resultsmentioning

confidence: 99%

Section: Total and Grade 3 To 4 Adverse Events And Adverse Event-rementioning

confidence: 99%

See 2 more Smart Citations

A systematic review of adverse events of rifapentine and isoniazid compared to other treatments for latent tuberculosis infection

Pease

Hutton

Yazdi

et al. 2018

Pharmacoepidemiology and Drug

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“…In attempts to improve completion rates, some experts have increasingly used the 4-month regimen of rifampin, which had typically been recommended for LTBI treatment among those exposed to isoniazid-resistant strains. 104,105 …”

Section: Managementmentioning

confidence: 99%

Tuberculosis in Children

Thomas

2017

Pediatric Clinics of North America

103

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Synopsis Mycobacterium tuberculosis is the leading cause of death worldwide from a single bacterial pathogen. World Health Organization (WHO) estimates that annually, 1 million children have TB disease and many more harbor a latent form of infection. However, accurate estimates are hindered by under-recognition and challenges in diagnosis; to date, an accurate diagnostic test to confirm TB in children does not exist. TB treatment is lengthy, but outcomes are generally favorable with timely initiation. As we move toward the End TB Strategy, there is an urgent need for improved diagnostics and treatment to prevent the unnecessary morbidity and mortality from TB in children.

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Low prioritization of latent tuberculosis infection—A systemic barrier to tuberculosis control: A qualitative study in Ontario, Canada

Milinkovic

Birch

Scott

et al. 2018

Health Planning & Management

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SummaryBackgroundEliminating tuberculosis (TB) in low‐incidence countries is an important global health priority, and Canada has committed to achieve this goal. The elimination of TB in low‐incidence countries requires effective management and treatment of latent tuberculosis infection (LTBI). This study aimed to understand and describe the system‐level barriers to LTBI treatment for immigrant populations in the Greater Toronto and Hamilton Area, Ontario, Canada.MethodsA qualitative study that used purposive sampling to recruit and interview health system advisors and planners (n = 10), providers (n = 13), and clients of LTBI health services (n = 9). Data were recorded, transcribed verbatim, and analyzed using content analysis.ResultsLow prioritization of LTBI was an overarching theme that impacted four dimensions of LTBI care: management, service delivery, health literacy, and health care access. These factors explained, in part, inequities in the system that were linked to variations in health care quality and health care access. While some planners and providers at the local level were attempting to prioritize LTBI care, there was no clear pathway for information sharing.ConclusionsThis multiperspective study identified barriers beyond the typical socioeconomic determinants and highlighted important upstream factors that hinder treatment initiation and adherence. Addressing these factors is critical if Canada is to meet the WHO's global call to eradicate TB in all low incidence settings.

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Safety and completion of a 4-month course of rifampicin for latent tuberculous infection in children

Abstract: Completion rates for 4RMP surpassed those of 9INH for all methods of delivery, except for DOPT, where completion rates were similar. 4RMP was well tolerated. The increased cost of 4RMP over 9INH may be offset by increased effectiveness, as gauged by completion rates.

Cited by 30 publications

References 0 publications

A systematic review of adverse events of rifapentine and isoniazid compared to other treatments for latent tuberculosis infection

A systematic review of adverse events of rifapentine and isoniazid compared to other treatments for latent tuberculosis infection

Tuberculosis in Children

Low prioritization of latent tuberculosis infection—A systemic barrier to tuberculosis control: A qualitative study in Ontario, Canada

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