In vitro and in silico antidiabetic activity of pyran ester derivative isolated from Tragia cannabina

Sivajothi, V.; Dakappa, Shruthi Shirur

doi:10.12980/apjtb.4.2014c1049

Cited by 17 publications

(14 citation statements)

References 14 publications

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“…This study also confirmed the nontoxic properties of the ethanolic extract of T. cannabina leaf (Sivajothi et al, 2007). Moreover, the antidiabetic effect of an isolated phytocompound, 4-oxo-4H-pyran-2,6-dicarboxylic acid-bis-[6-methyl-heptyl] ester from T. cannabina have been demonstrated using in vitro streptozotocin (STZ) -treated chick embryo and in silico docking studies targeting active sites of AMPK (Sivajothi and Dakappa, 2014).…”

Section: Tragia Cannabinasupporting

confidence: 73%

Phytochemical, Pharmacological and Biological Profiles of Tragia Species (Family: Euphorbiaceae)

Reddy¹,

Rao²,

Vijeepallam³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Tragia belongs to the family Euphorbiaceae which contains about 152 species. Interestingly, most of the earlier investigations have been done using only five Tragia species, namely, Tragia involucrata, Tragia cannabina, Tragia spathulata, Tragia plukenetii, and Tragia benthamii. The objective of the present review is to compile the phytochemical, pharmacological and biological studies of the selected five Tragia species reported in the literature. Methods: The reported data/information was retrieved mainly from the online databases of PubMed (MEDLINE), EMBASE and Botanical Survey of India. Results: The present review elaborated the phytochemical, pharmacological and biological properties of the selected five Tragia species obtained from recent literature. Conclusion:This review provides a basis for future investigation of Tragia species and, especially for those species that have not been explored for biological and pharmacological activities.

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Section: Tragia Cannabinasupporting

confidence: 73%

Phytochemical, Pharmacological and Biological Profiles of Tragia Species (Family: Euphorbiaceae)

Reddy¹,

Rao²,

Vijeepallam³

et al. 2017

Afr J Tradit Complement Altern Med

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“…Ar-Tumerone; 9, 10 Anthracenedione 1,8-dihydroxy-3-methyl and Friedelane-3-one were identified from the methanol extract 31 . Presence of a pyaran ester derivative, 4-Oxo-4H-pyran-2,6-dicarboxylic acid bis-[6-methyl-heptyl] ester has been confirmed from the chloroform extracts of the roots of T. cannabina 32 . GCMS analysis from the ethanolic extract T. plukenetii exhibited the presence of a series of compounds such as 1,1-diethoxy-2-methylpropane, 1,1-diethoxy-2-methylbutane, (1-methyl-2-pyrrolidinyl)methanol, (2,2-diethoxyethyl)benzene, 4-(2,4,4-trimethlcyclohexa-1,5-dienyl) but-3-ene-2-one, Neophytadiene, 16-heptadecanal,Neophytadiene, Ethyl linoleolate, Alpha-tocopherol-beta-D-mannoside and Stigmast-5-en-3-ol (3-beta,24S)-Clionasterol 33 .…”

Section: Phytochemistrymentioning

confidence: 91%

Pharmacological Potential of the Stinging Plant Tragia Species: A Review

Narasimhan¹

2021

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Tragia is well known in the botanical world a stinging plants. Apart from this, the genus also occupies an important constituent of alternative systems of medicine as well as ethnobotany. Among the various species of Tragia, the most studied and experimented species is T. involucrata. This genus is used for several ethnobotanical uses such as cancer, diarrhea, constipation, scorpion bite, rheumatism, whooping cough and diabetes. Apart from this the genus is also an important constituent of ayurvedic and siddha medicines. Owing to these properties several researches has been conducted to validate the traditional uses, finding out new uses and understanding the phytochemical profile. Alkaloids, phenols, terpenoids and tannin are present in the genus Tragia. Calcium oxalate and shellsol is responsible for the stinging property. Various species of Tragia has been validated for its important properties such as antibacterial, antifungal, cytotoxic, wound healing and anti-inflammatory activities. All these properties has been related to the occurrence of secondary metabolites. However the exact lead metabolite for the pharmacological properties has to be identified. Based the experimentally proved pharmacological properties, Tragia possesses significant potential on a medicinal species.

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“…SPF eggs were kept in the incubators at 70% humidity and 37.5 0 C. STZ (N-(Methyl Nitroso Carbamoil)-a-D-glucosamine, CAS Number: 18883-66-4, Sigma-Aldrich Chemie GmbH, Germany) was dissolved in saline and a stock STZ solution was prepared. STZ doses given to chick embryos were determined according to the literature (15)(16)(17)(18). There were 14 groups in total, with 10 SPF fertilized eggs in each group.…”

Section: Ethics Committee Approval Was Obtained From Afyon Kocatepe U...mentioning

confidence: 99%

The effect of vitamin K1 on VEGF levels in chick embryos with type 1 diabetes and Diabetic Retinopathy induced by streptozotocin

et al. 2021

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Objective: Hyperglycemia caused by Diabetes Mellitus (DM) is associated with long-term dysfunction such as diabetic retinopathy (DRP). The most effective growth factor in the development of DRP is the vascular endothelial growth factor (VEGF). Vitamin K1 reduces hyperglycemia and prevents the development of DM. In this study, we aimed to create streptozotocin (STZ) induced DM and DRP in chick embryos and to show whether vitamin K1 can prevent early-stage DRP by measuring VEGF levels. Material and Methods: The 140 specific pathogen-free (SPF) fertilized chicken eggs were used in this study. Three different STZ doses were administered to 120 SPF eggs for an induced DM model. Three different vitamin K1 doses were administered in each STZ dose group. On the 12th day and 18th day the remaining 20 SPF eggs were separated as control groups. On the 18th-day, blood glucose, blood insulin and VEGF levels were measured. Results: 0.45 mg/egg STZ dose (STZ3) was determined as the optimal/ideal dose for the DM model. When the group-administered STZ3 and vitamin K1 were evaluated among themselves; it was determined that there were significant changes in blood glucose, blood insulin, VEGF levels of the STZ3+K1-3 group compared to the STZ3+K1-1 and STZ3+K1-2 groups (p<0.05). Conclusion: Vitamin K1 increases blood insulin levels and decreases blood glucose levels. When hyperglycemia reduces, the VEGF levels reduce. Vitamin K1 protects from DRP by reducing VEGF levels.

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In vitro and in silico antidiabetic activity of pyran ester derivative isolated from Tragia cannabina

Abstract: The significant glucose levels were reduced (P<0.01) after administration of the pyran ester isolated from T. cannabina to streptozotocin treated chick embryo.

Cited by 17 publications

References 14 publications

Phytochemical, Pharmacological and Biological Profiles of Tragia Species (Family: Euphorbiaceae)

Phytochemical, Pharmacological and Biological Profiles of Tragia Species (Family: Euphorbiaceae)

Pharmacological Potential of the Stinging Plant Tragia Species: A Review

The effect of vitamin K1 on VEGF levels in chick embryos with type 1 diabetes and Diabetic Retinopathy induced by streptozotocin

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