A
            <i>bla</i>
            <sub>VIM-2</sub>
            Plasmid Disseminating in Extensively Drug-Resistant Clinical Pseudomonas aeruginosa and Serratia marcescens Isolates

Vilacoba, Elisabet; Quiroga, Cecilia Medina; Pistorio, Mariano; Famiglietti, Ángela; Rodríguez, Hernán B.; Kovensky, Jaime; Déraspe, Maxime; Raymond, Frédéric; Roy, Paul H.; Centrón, Daniela

doi:10.1128/aac.02934-14

Cited by 18 publications

(20 citation statements)

References 10 publications

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“…They are also related to TNCP23, a region carrying a class 1 integron bounded by two copies of IS6100 (IS6 family) that seems to correspond to a plasmid inserted into the larger plasmid pKLC102, which is itself known to integrate as a genomic island (see below) (325). Other, unrelated plasmids carry bla VIM-1 (duplicate copies giving high-level carbapenem resistance) (323), bla VIM-2 (326), or bla VIM-7 (327).…”

Section: Resistance Plasmids In P Aeruginosamentioning

confidence: 99%

Mobile Genetic Elements Associated with Antimicrobial Resistance

et al. 2018

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SUMMARYStrains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an increasing major health care problem around the world. It is now abundantly clear that both Gram-negative and Gram-positive bacteria are able to meet the evolutionary challenge of combating antimicrobial chemotherapy, often by acquiring preexisting resistance determinants from the bacterial gene pool. This is achieved through the concerted activities of mobile genetic elements able to move within or between DNA molecules, which include insertion sequences, transposons, and gene cassettes/integrons, and those that are able to transfer between bacterial cells, such as plasmids and integrative conjugative elements. Together these elements play a central role in facilitating horizontal genetic exchange and therefore promote the acquisition and spread of resistance genes. This review aims to outline the characteristics of the major types of mobile genetic elements involved in acquisition and spread of antibiotic resistance in both Gram-negative and Gram-positive bacteria, focusing on the so-called ESKAPEE group of organisms (, ,, ,, spp., and), which have become the most problematic hospital pathogens.

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Section: Resistance Plasmids In P Aeruginosamentioning

confidence: 99%

Mobile Genetic Elements Associated with Antimicrobial Resistance

et al. 2018

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“…Certain plasmids are conjugative and can be passed between members of the Enterobacteriaceae and with other gram negative pathogens such as A. baumannii and Pseudomonas aeruginosa [Vilacoba 2014]. Class A, B, and D carbapenemases contained on mobile gene elements within these plasmids is a core factor in the rapid spread of CRE [Mathers 2015].…”

Section: Plasmid Repliconsmentioning

confidence: 99%

The rapid spread of carbapenem-resistant Enterobacteriaceae

Potter

D’Souza

Dantas

2016

Drug Resistance Updates

321

211

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Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Successful expansion of Enterobacteriaceae clonal groups and frequent horizontal gene transfer of carbapenemase expressing plasmids are causing increasing carbapenem resistance. Recent advances in genetic and phenotypic detection facilitate global surveillance of CRE diversity and prevalence. In particular, whole genome sequencing enabled efficient tracking, annotation, and study of genetic elements colocalized with carbapenemase genes on chromosomes and on plasmids. Improved characterization helps detail the co-occurrence of other antibiotic resistance genes in CRE isolates and helps identify pan-drug resistance mechanisms. The novel β-lactamase inhibitor, avibactam, combined with ceftazidime or aztreonam, is a promising CRE treatment compared to current colistin or tigecycline regimens. To halt increasing CRE-associated morbidity and mortality, we must continue quality, cooperative monitoring and urgently investigate novel treatments.

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“…In P. aeruginosa, bla VIM-2 is most often associated with class 1 integrons containing additional antibiotic resistance genes (3)(4)(5)(6)(7)(8)(9)(10)(11). The bla VIM-2 gene has been commonly associated with chromosomally located Tn402-like class 1 integrons (3)(4)(5)(6)(7)(8).…”

mentioning

confidence: 99%

“…Until now, only two complete bla VIM-2 -carrying plasmid sequences in P. aeruginosa, pNOR-2000 and pDCPR1, have been described (10,11). In order to obtain new insight about the mobile elements contributing to the dissemination of this gene, we report here the complete sequence of pJB12, a bla VIM-2 -carrying plasmid from a P. aeruginosa clinical isolate, and we explore the genetic background involved in acquisition of the bla VIM-2 -harboring In58 integron.…”

mentioning

confidence: 99%

Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn 6352 , a Novel Putative Transposon Associated with Mobilization of the bla _VIM-2 -Harboring In58 Integron

Botelho

Grosso

Peixe

2017

Antimicrob Agents Chemother

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The bla VIM-2 -carrying In58 integron has been linked to a chromosomal location in different bacterial species, including Pseudomonas aeruginosa. This work reports the first fully sequenced In58-harboring plasmid, which is significantly different from the two previously identified bla VIM-2 -carrying plasmids in P. aeruginosa. bla VIM-2 might have been acquired by transposition of Tn6352, a novel transposon composed of the In58 and ISPa17 elements. The recognition of similar inverted repeat (IR) sites by ISPa17 reveals a common mobilization process associated with acquisition of the bla VIM-2 and bla VIM-1 genes.

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A bla _VIM-2 Plasmid Disseminating in Extensively Drug-Resistant Clinical Pseudomonas aeruginosa and Serratia marcescens Isolates

Cited by 18 publications

References 10 publications

Mobile Genetic Elements Associated with Antimicrobial Resistance

Mobile Genetic Elements Associated with Antimicrobial Resistance

The rapid spread of carbapenem-resistant Enterobacteriaceae

Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn 6352 , a Novel Putative Transposon Associated with Mobilization of the bla _VIM-2 -Harboring In58 Integron

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A bla VIM-2 Plasmid Disseminating in Extensively Drug-Resistant Clinical Pseudomonas aeruginosa and Serratia marcescens Isolates

Cited by 18 publications

References 10 publications

Mobile Genetic Elements Associated with Antimicrobial Resistance

Mobile Genetic Elements Associated with Antimicrobial Resistance

The rapid spread of carbapenem-resistant Enterobacteriaceae

Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn 6352 , a Novel Putative Transposon Associated with Mobilization of the bla VIM-2 -Harboring In58 Integron

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A bla _VIM-2 Plasmid Disseminating in Extensively Drug-Resistant Clinical Pseudomonas aeruginosa and Serratia marcescens Isolates

Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn 6352 , a Novel Putative Transposon Associated with Mobilization of the bla _VIM-2 -Harboring In58 Integron