Predictive value of SUV-based parameters derived from pre-treatment 18F-FLT PET/CT for short-term outcome with head and neck cancers

Hoshikawa, Hiroshi; Yamamoto, Yuka; Mori, Terushige; Kishino, Takehito; Fukumura, Takashi; Samukawa, Yasushi; Mori, Nozomu; Nishiyama, Yoshihiro

doi:10.1007/s12149-014-0902-1

Cited by 13 publications

(11 citation statements)

References 31 publications

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“…SUV peak has been proposed to overcome the shortcoming of SUV max , defined as the average SUV within a small, fixed size region of interest centered on a high uptake part of the tumor (18). SUV peak has been reported (11,19,20) to be prognostic in several types of malignancy. In patients with osteosarcoma, we revealed that SUV peak at the posttherapy scan is an independent prognostic factor for OS.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Metabolic and Volumetric Parameters of FDG PET in Pediatric Osteosarcoma: A Hypothesis-generating Study

Im¹,

Zhang²,

Wu³

et al. 2018

Radiology

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Purpose To preliminarily assess the potential prognostic value of various fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) parameters before, during, and after neoadjuvant chemotherapy (NCT). Materials and Methods Thirty-four patients with osteosarcoma were enrolled prospectively from 2008 to 2012 and underwent FDG PET/computed tomography (CT) imaging before (baseline scan), during (interim scan) and after NCT (posttherapy scan). The study was approved by the institutional review board and informed consent was received from patients. Maximum and peak standardized uptake value (SUV and SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. Predictive value of FDG PET parameters for event-free survival (EFS) and overall survival (OS) were evaluated. Multivariable Cox regression analysis for EFS and OS was performed by using histologic response and initial presence of metastasis as covariates. Results At baseline scan, SUV, MTV, and TLG were predictive of EFS (P = .006-.03) and OS (P = .001-.03) but not associated with histologic response. At interim and posttherapy scan, SUV, SUV, MTV, and TLG were associated with histologic response (P = .0002-.04) and predictive of EFS (P = .004-.02) and OS (P = .001-.03). Multivariable Cox regression analysis revealed that the FDG PET parameters either at baseline, interim, or posttherapy were independently predictive of EFS and OS. In particular, baseline MTV was an independent predictor of EFS (hazard ratio, 5.0 [95% confidence interval {CI}: 1.5, 16.8]) and OS (hazard ratio, 29.4 [95% CI: 2.2, 392.2]). Conclusion SUV, MTV, and TLG either at baseline, interim, or posttherapy were predictive of EFS and OS and may be useful prognostic biomarkers for osteosarcoma. RSNA, 2018 Online supplemental material is available for this article.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Metabolic and Volumetric Parameters of FDG PET in Pediatric Osteosarcoma: A Hypothesis-generating Study

Im¹,

Zhang²,

Wu³

et al. 2018

Radiology

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“…Similar findings were reported by some of the previous studies. In a study of 32 patients with HNSCC, Hoshikawa et al showed that metabolic tumor volume and total lesion proliferation based on pretreatment FLT-PET were significantly associated with locoregional control and overall survival, while SUV max played no prognostic role 28 . In another study of 26 high-grade glioma patients, Idema et al showed that both FLT-derived proliferative volumes adapted by the signal-to-background ratio (PV SBR ) and SUV max were predictive of OS in univariate analysis, but only PV SBR remained statistically significant in multivariate analysis 35 .…”

Section: Discussionmentioning

confidence: 99%

Volumetric parameters derived from FLT-PET performed at completion of treatment predict efficacy of Carbon-ion Radiotherapy in patients with locally recurrent Nasopharyngeal Carcinoma

Hu¹,

Yang²,

Gao³

et al. 2020

J. Cancer

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The purpose of this study was to investigate the role of 3'-deoxy-3'-[ 18 F]fluorothymidine (FLT)-PET for predicting the outcome of patients with locally recurrent nasopharyngeal carcinoma (LR-NPC) treated by carbon-ion radiotherapy (CIRT). Patients received FLT-PET/CT scan one-week prior to or after completion of CIRT were enrolled in the study. All patients were from prospective trials or treated using a standardized protocol. Time-dependent receiver operator characteristics (ROC) were used to determine the optimal cutoff values for FLT-PET parameters. Univariable and multivariable analyses of local progression-free survival (LPFS) were performed using Cox regression, to examine the prognostic value of FLT-PET parameters, including SUV max , metabolic tumor volume (MTV) and total lesion thymidine (TLT). A total of 41 patients were enrolled. Elevated MTV and TLT were significantly associated with worse LPFS, in both univariable and multivariable analyses. ROC analysis revealed that both an MTV value higher than 8.6 and a TLT value higher than 14.9 were predictive of increased risk of developing local recurrence, the adjusted HRs were 5.59 ( p =0.009) and 7.76 ( p =0.002), respectively. In conclusion, FLT-PET was found to be a promising prognostic tool for LR-NPC patients and might play a role in the treatment guidance.

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“…42 There is an increasing assortment of radiotracers targeting alternate pathways (fluorothymidine F 18, cellular proliferation), receptor targets, and tumor environmental conditions (fluoromisonidazole F 18, tumor hypoxia) that may prove useful for further characterizing HNSCC in patients. [43][44][45]…”

Section: Prognostic Evaluation With Functional Imagingmentioning

confidence: 99%

Multimodal Imaging of Head and Neck Squamous Cell Carcinoma

et al. 2017

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Predictive value of SUV-based parameters derived from pre-treatment 18F-FLT PET/CT for short-term outcome with head and neck cancers

Abstract: Pre-treatment MTV is the most useful parameter with FLT PET/CT. TLP and SUVpeak may also provide important prognostic information for patients with HNSCCs.

Cited by 13 publications

References 31 publications

Prognostic Value of Metabolic and Volumetric Parameters of FDG PET in Pediatric Osteosarcoma: A Hypothesis-generating Study

Prognostic Value of Metabolic and Volumetric Parameters of FDG PET in Pediatric Osteosarcoma: A Hypothesis-generating Study

Volumetric parameters derived from FLT-PET performed at completion of treatment predict efficacy of Carbon-ion Radiotherapy in patients with locally recurrent Nasopharyngeal Carcinoma

Multimodal Imaging of Head and Neck Squamous Cell Carcinoma

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