Japanese Guideline for Occupational Allergic Diseases 2014

Abstract

In 2013, a guideline for occupational allergic diseases was published for the first time in Japan. Occupational allergic diseases are likely to worsen or become intractable as a result of continuous exposure to high concentrations of causative antigens, and are socioeconomically important diseases with which the patients might sometimes lose jobs due to work interruptions. Guidelines for occupational allergic diseases have been published in many countries. This guideline consists of six chapters about occupational asthma, occupational allergic rhinitis, occupational skin diseases, hypersensitivity pneumonitis and occupational anaphylaxis shock, and legal aspects of these diseases. The guideline is characterized with the following basic structure: Clinical Questions (CQs) are set with reference to Minds (Medical Information Network Distribution Service), statements by the committee are correspondingly listed, recommended grades and evidence levels are defined, and then descriptions and references are indicated.

Management of asthma exacerbation in children

“…Ancak 2014 yılında yayınlanan Japonya Çocukluk Çağı Astım Rehberi'nde, beta2 agonist ve sistemik KS tedavisine yanıt alınamayan, solunum yetmezliği olan hastalarda verilebileceği, fakat serum düzeyinin yakın izlenmesi önerilmekte-dir. Ancak, konvülziv hastalığı olanlarda verilmesi önerilmemektedir (25) .…”

Identification and practical management of latex allergy in occupational settings

“…It is of utmost importance to identify the occupational allergic diseases in their early stages [76]. Diagnosis of IgE-mediated occupational allergic diseases is often difficult, because the identification of causative agents out of numerous exposures at the workplace using the common diagnostic tools and procedures is a complex undertaking.…”

“…It is frequently accompanied by red, watery, itchy eyes (conjunctivitis) [74,75] Asthma Wheezing, shortness of breath, cough, chest tightness due to inflamed and constricted airways due to inhalation of latex-derived agents [74][75][76][77] Anaphylaxis Severe systemic reaction, with rapid onset of airway, breathing, circulatory, or gastrointestinal problems, usually associated with skin and mucosal changes [70,[78][79][80] Review Caballero & Quirce antigen contents of the SPT solutions varied remarkably depending on the manufacturer. The lack of standardization of the SPT extracts leads to an unequal amount of proteins among the different extracts, with the presence of irrelevant proteins and in most cases, low amounts of major allergens [94].…”

“…[69][70][71][72][73][74][75][76][77][78][79][80]. Reactions usually begin within minutes of exposure, and the clinical manifestations vary greatly depending on the route of exposure, the amount of allergen, degree of sensitization and other individual factors…”

Occupational Allergies: A Brief Review

“…Consequently, mild-to-severe medical injuries or pathologic conditions, together with job loss and economic burden, could occur. 2 Usually, the entire body of a worker with a certain genetic background is affected by allergens in the workplace. Skin and respiratory systems, the first exposed organs, are the most frequent roots of occupational exposure, which may cause local or systemic allergic (immunologic) disorders.…”