IgG4-Related Disease and Sensorineural Hearing Loss

Gallo, Jesica; Ortiz, Alberto; Paira, Sergio

doi:10.3342/ceo.2014.7.3.236

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…In this article, we reported the case of a patient with IgG4-RD who had recurrent otitis media and mixed hearing loss. Cho et al 2 reported a case of fluctuating mixed-type hearing loss, whereas Gallo et al 3 reported three cases of sensorineural hearing loss. Later, Cho et al 11 clarified their findings to report that air-bone gap did not improve with ventilation tube insertion and antibiotics during the initial treatment; rather, it improved with immunosuppressive therapy.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin G4-Related Disease Presented as Recurrent Otitis Media and Mixed Hearing Loss Treated With Cyclophosphamide and Rituximab: A Case Report

et al. 2019

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Immunoglobulin G4-related disease (IgG4-RD) is a systemic autoimmune disease, primarily affecting various organ systems such as the pancreas, biliary tree, and liver. The orbit, salivary glands, the thyroid, facial skin, the trigeminal nerve, and the cervical lymph nodes are often affected by IgG4-RD in the head and neck region. 1 Although the ear is rarely affected, few case reports (we found 11 cases, listed in Table 1) of otologic manifestation can be found in the literature. 2-6 We excluded one case in Israel which was presented only in the congress. Of the 11 cases, seven were reported in Asia, and all the 11 cases were treated with steroids, one of them with a combination of methotrexate. Herein, we report the 12 th case of IgG4-RD involving the middle and inner ear. We treated this patient with cyclophosphamide and rituximab, which have never been used to treat otologic symptoms, but were used to treat other organs affected by IgG4-RD. 7-10 Pure tone audiometry was recorded serially to define the clinical improvement. In addition, we found that early treatment may lead to better outcomes.

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Section: Discussionmentioning

confidence: 99%

Immunoglobulin G4-Related Disease Presented as Recurrent Otitis Media and Mixed Hearing Loss Treated With Cyclophosphamide and Rituximab: A Case Report

et al. 2019

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“…[7][8][9] Data on IgG4-RD come almost exclusively from cohorts from Asia, Europe, and North America, [10][11][12][13][14][15][16] but little information is available from Latin America. [17][18][19][20] We conducted this study to describe the clinical presentation, phenotype distribution, and its association with sex, ethnicity, and serological markers in a large cohort of Latin American patients with IgG4-RD.…”

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confidence: 99%

“…For example, in non-White Latin American patients, systemic lupus erythematosus presents at a younger age and have more frequently renal involvement, Latin American Sjögren syndrome patients present less frequently systemic activity at diagnosis, and Hispanic American ANCA-associated vasculitis patients have more frequently renal involvement and more severe disease 7–9 . Data on IgG4-RD come almost exclusively from cohorts from Asia, Europe, and North America, 10–16 but little information is available from Latin America 17–20 …”

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confidence: 99%

Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype

et al. 2022

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Background/Objective: Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts from Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, and association with sex, ethnicity, and serological markers in a large cohort of Latin American patients with IgG4-RD. Methods:We performed a multicenter medical records review study including 184 Latin American IgG4-RD patients. We assigned patients to clinical phenotypes: group 1 (pancreato-hepato-biliary), group 2 (retroperitoneal/ aortic), group 3 (head and neck-limited), group 4 (Mikulicz/systemic), and group 5 (undefined). We focused the analysis on how sex, ethnicity, and clinical phenotype may influence the clinical and serological presentation. Results:The mean age was 50.8 ± 15 years. Men and women were equally affected (52.2% vs 48.8%). Fifty-four patients (29.3%) were assigned to group 1, 21 (11.4%) to group 2, 57 (30.9%) to group 3, 32 (17.4%) to group 4, and 20 (10.8%) to group 5. Male sex was associated with biliary tract (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.36-8.26), kidney (OR, 3.4; 95% CI, 1.28-9.25), and retroperitoneal involvement (OR, 5.3; 95% CI,. Amerindian patients presented more frequently with atopy history and gallbladder involvement. Group 3 had a female predominance.Conclusions: Latin American patients with IgG4-RD were younger, and men and women were equally affected compared with White and Asian cohorts. They belonged more commonly to group 1 and group 3. Retroperitoneal and aortic involvement was infrequent. Clinical and serological features differed according to sex, ethnicity, and clinical phenotype.

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