Low-level mercury in children: Associations with sleep duration and cytokines TNF-α and IL-6

Gump, Brooks B.; Gabrikova, Elena; Bendinskas, Kestutis; Dumas, Amy K.; Palmer, Christopher D.; Parsons, Patrick J.; MacKenzie, James A.

doi:10.1016/j.envres.2014.07.026

Cited by 26 publications

(7 citation statements)

References 32 publications

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“…The study of TNF-α and IL-6 levels in the blood serum of children aged 9 to 11 yr, an increase of Hg levels were associated with a shorter sleep duration and a lower TNF-α level. IL-6 was not associated with sleep or blood mercury (27). A crosssectional study of the population in Amazonian Brazil (28) demonstrated that the levels of proinflammatory cytokines IL-1, TNF-α and IFN-γ were significantly higher in mercury-exposed subjects and anti-nucleolar autoantibodies + (AN (o) A +) as compared to participants with lower mercury exposure.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Cytokine Profile and Hypertension among the Mercury-Exposed Residents of Temirtau Region in Central Kazakhstan

Shinetova¹,

Akparova²,

Bekeyeva³

2020

ijph

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Background: Mercury is a common environmental contaminant and it is also harmful to human health. Among reported toxicities, its harmful effect on hypertension is poorly documented. In Kazakhstan, Temirtau city has been reported to have a high level of mercury contamination from an acetaldehyde production factory. Therefore, we aimed to investigate the association between serum profile of cytokines and the development of hypertension among the exposed citizens. Methods: We selected 81 individuals for study, out of them, 41 exposed ones suffered hypertension and 40 – unexposed healthy controls in villages Chkalovo, Samarkand, Gagarinskoye, Tegiszhol, Rostovka in 2016. Mercury content in urine was studied by inversion voltammetry. Cytokine levels of IL-2, IL-6, IL-10 and TNF-α were determined by ELISA. Results: Mercury-exposed citizens, especially those with hypertension, had significantly higher concentrations of inflammatory cytokines TNF-α, IL-2, IL-6 and anti-inflammatory cytokine IL-10 as compared to the unexposed population. The dependence of the mercury level in urine on IL-2 content was also detected. Therefore, chronic low doses of exposure to mercury were associated with an increase in serum levels of immune markers and with the increased risk of hypertension. Conclusion: The presence of mercury in the body probably affected the expression of interleukin-2, one of the main cytokines that coordinate immune response.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Cytokine Profile and Hypertension among the Mercury-Exposed Residents of Temirtau Region in Central Kazakhstan

Shinetova¹,

Akparova²,

Bekeyeva³

2020

ijph

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“…Mercury exposure also results in changes in cytokine production. In children, mercury exposure has been found to be associated with reduced levels of TNF-alpha and shorter sleep duration [63]. One possible mechanism of sleep disruption by Hg is the effect on glutamate, which results in increased extracellular glutamate and a possible excitotoxic effect [64].…”

Section: Mercurymentioning

confidence: 99%

Sleep deprivation: A toxicogenic drive for neurodegenerative diseases and public health issue

Afonne¹,

Ifediba²,

Afonne³

2022

Adv Health Behav

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Sleep deprivation is gradually becoming a common phenomenon in modern societies, especially among chronic users of social media, night shifts workers, students and some less-privileged populations. The erroneous perception among certain subgroups of the population that time spent to sleep is time wasted is of great concern, because sleep is indeed critical for good health and survival. Of greater concern are the effects of alcohol, beverages like caffeine and environmental toxicants like heavy metals and pesticides on normal sleep mechanisms. The consequences of sleep disorder are dire as it alters immune responses and have been reported to increase the risk of some non-communicable diseases. The inter-individual differences in sleep requirements may present a challenge in determining adequate sleep duration. On the average, most adults need about seven to eight hours of sleep each night while teens and children need more. Accumulation of sleep debt for individuals sleeping less than the required sleeping duration may lead to chronic health and behavioural problems. We opine that the mechanisms underlying sleep disruption by some foods and toxicants have toxicogenic link. There is need, therefore, to consider sleep deprivation as a public health issue with a view to ensuring proper advocacy among risk groups in order to improve quality of life and economy of nations. Given the prevalence of alcohol and caffeine consumption, exposures to heavy metals and pesticides, and increasing neurodegenerative disorders, there is need to elucidate the precise mechanisms of sleep disruption and exposures to the aforementioned chemicals.

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“…Another heavy metal as mercury induced effect on neuroimmune signaling, mercury exposure cause increase in TNF-α expression in hippocampus and cerebellum (test in prairie voles) (Thomas Curtis et al 2011 ). Interesting studies have been conducted by Gump et al 2014 . They showed that increasing blood Hg (9–11 children) was correlated with lower concentration of TNF-α in whole blood and shorter sleep duration.…”

Section: Cytokines In Milkmentioning

confidence: 99%

The impact of environmental pollution on the quality of mother's milk

Pajewska-Szmyt

Sinkiewicz–Darol

Gadzała‐Kopciuch

2019

Environ Sci Pollut Res

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Breastfeeding is a gold standard of neonate nutrition because human milk contains a lot of essential compounds crucial for proper development of a child. However, milk is also a biofluid which can contain environmental pollution, which can have effects on immune system and consequently on the various body organs. Polychlorinated biphenyls are organic pollutants which have been detected in human milk. They have lipophilic properties, so they can penetrate to fatty milk and ultimately to neonate digestive track. Another problem of interest is the presence in milk of heavy metals—arsenic, lead, cadmium, and mercury—as these compounds can lead to disorders in production of cytokines, which are important immunomodulators. The toxicants cause stimulation or suppression of this compounds. This can lead to health problems in children as allergy, disorders in the endocrine system, end even neurodevelopment delay and disorder. Consequently, correlations between pollutants and bioactive components in milk should be investigated. This article provides an overview of environmental pollutants found in human milk as well as of the consequences of cytokine disorder correlated with presence of heavy metals. Graphical abstract

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Low-level mercury in children: Associations with sleep duration and cytokines TNF-α and IL-6

Cited by 26 publications

References 32 publications

The Relationship between Cytokine Profile and Hypertension among the Mercury-Exposed Residents of Temirtau Region in Central Kazakhstan

The Relationship between Cytokine Profile and Hypertension among the Mercury-Exposed Residents of Temirtau Region in Central Kazakhstan

Sleep deprivation: A toxicogenic drive for neurodegenerative diseases and public health issue

The impact of environmental pollution on the quality of mother's milk

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