Density, structure, and strength of the distal radius in patients with psoriatic arthritis: the role of inflammation and cardiovascular risk factors

Abstract

There is an intertwined relationship between chronic inflammation, cardiovascular risk factors, and bone loss in PsA. PsA patients seem to have unique bone microstructural deficits which are associated with a propensity to bone fragility.

Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2

“…The association between sST2 with compromised bone quality in terms of low cortical vBMD and TMD and was attenuated by adjusting for traditional osteoporotic risk factors, suggesting that the latter might partially mediate the effect of inflammation on osteoporosis. More importantly, compromised cortical bone quality was also the featured pattern of bone microstructural deficits in our PsA patients compared with controls15.…”

“…The vBMD and microstructure of 53 out of the 80 patients comparing with age and gender matched controls had been published before15. Exclusion criteria were history of a disorder or using a drug that could affect bone metabolism; and pregnant or breastfeeding15. Treatment with glucocorticoids, calcium, and/or vitamin supplement was allowed.…”

“…A recent meta-analysis revealed that PsA patients had an higher frequency of having carotid plaque compared with healthy controls [odds ratio (OR): 3.12]10. Although studies on the areal BMD (aBMD) by dual-energy X-ray absorptiometry (DXA) yielded conflicting results111213, two recent studies evaluated the bone quality of distal radius using high-resolution peripheral quantitative computed tomography (HR-pQCT) and found compromised volumetric BMD (vBMD) and microstructure in PsA patients1415. This may be due to the advantages that HR-pQCT assesses the 3 dimensional structures in a high spatial resolution of 130 μm, while DXA projects structures onto 2 dimensional images16.…”

Bone remodeling in psoriasis and psoriatic arthritis

“…Unique bone microstructural deficits appearing as lower cortical volumetric BMD, higher endocortical perimeter and cortical pore volume on high-resolution peripheral quantitative computed tomography (HR-pQCT) were associated with higher propensity to bone fragility [2].…”

Systemic Osteoporosis and Psoriatic Arthritis: Current Understanding of the Problem

“…Zhu и со-авт. [24] значимых различий в значениях МПК, получен-ных с помощью DXA, у пациентов с ПсА и контрольной группы не было выявлено. Однако пККТ продемонстри-ровала, что показатели, связанные с качеством корти-кальной кости, ее микроархитектурой, у пациентов с ПсА в значительной мере хуже, чем в группе контроля.…”