Séroprévalence de l’Ag HBs et de l’anticorps Anti VHC chez les personnes infectées par le VIH1 à N’Djamena, Tchad

Nadlaou, Bessimbaye; Moussa, Amira; Mbanga, Djimadoum; Tidjani, Abdelsalam; Mahamat, S. O.; Ngawara, M. Nahor; Ngarnayal, G.; Fissou, H. Y.; Sangaré, Lassana; Ndoutamia, G.; Barro, Nicolas

doi:10.1007/s13149-014-0386-1

Cited by 12 publications

(10 citation statements)

References 10 publications

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“…Indeed, Chad is a country of generalized HIV epidemic with the adult prevalence rate at 3.5% in N’Djamena [60], as observed in our series. Chad is also a country of high HBV and HCV infections prevalences in adults, and in our study the prevalences of these viral infections were of the same order as those previously reported in N’Djamena in 2014 by Bessimbaye and colleagues [61]. Consequently, the rates of these three epidemiological infectious markers observed in our series tend to reflect the general epidemiology in Chad, thereby making our study sample close to the general population in Chad.…”

Section: Discussionsupporting

confidence: 88%

“…Study women were referred to the clinic “ La Renaissance Plus” of N’Djamena, although they were not part of the patients from the clinic, avoiding the obvious bias of recruitment by health care facilities. Furthermore, 9 (3.5%), 19 (7.5%) and 8 (3.2%) study participants were HIV-, HBsAg- and HCV-specific antibody- positive, respectively, in accordance with the high endemicity of these three major chronic viral infections in Chad [60, 61]. Indeed, Chad is a country of generalized HIV epidemic with the adult prevalence rate at 3.5% in N’Djamena [60], as observed in our series.…”

Section: Discussionmentioning

confidence: 94%

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High prevalence of cervical high-risk human papillomavirus infection mostly covered by Gardasil-9 prophylactic vaccine in adult women living in N’Djamena, Chad

et al. 2019

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Background We conducted in 2018 a descriptive, quantitative, population-based, cross-sectional survey estimating the prevalence of cervical high-risk human papillomavirus (HR-HPV) infection and associated risk factors among adult women living in N’Djamena, Chad. Methods Five of the 10 districts of N’Djamena were randomly selected for inclusion. Peer educators contacted adult women in community-churches or women association networks to participate in the survey and come to the clinic for women’s sexual health “ La Renaissance Plus ”, N’Djamena. Medical, socio-demographical and behavioral informations were collected. HPV DNA was detected and genotyped in endocervical swab using Anyplex II HPV28 genotyping test (Seegene, Seoul, South Korea). Results 253 women (mean age, 35.0 years; range, 25–65) including 3.5% of HIV-positive women were prospectively enrolled. The prevalence of HPV infection was 22.9%, including 68.9% of HR-HPV infection and 27.6% being infected with multiple genotypes, providing a total HR-HPV prevalence of 15.8% (95% CI%: 11.3–20.3). The most prevalent HR-HPV genotypes were HPV-58, HPV-35, HPV-56, HPV-31, HPV-16, HPV-45, HPV-52 and HPV-18. HPV types targeted by the prophylactic Gardasil-9 vaccine were detected in nearly 70% (67.5%) and HPV-58 was the most frequently detected. HIV infection was a risk factor strongly associated with cervical infection with any HPV [adjusted Odds ratio (aOR): 17.4], multiple types of HPV (aOR: 8.9), HR-HPV (aOR: 13.2) and cervical infection with multiple HR-HPV (aOR: 8.4). Conclusion These observations highlight the unsuspected high burden of cervical HR-HPV infection in Chadian women, and point the potential risk of further development of HPV-associated cervical precancerous and neoplastic lesions in a large proportion of women in Chad. The high rate of preventable Gardasil-9 vaccine genotypes constitutes the rationale for introducing primary vaccine prevention against cervical cancer in young female adolescents living in Chad.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 94%

High prevalence of cervical high-risk human papillomavirus infection mostly covered by Gardasil-9 prophylactic vaccine in adult women living in N’Djamena, Chad

et al. 2019

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“…Thus, study participants referred to clinic “ La Renaissance Plu s”, N'Djamena, were not patients from the clinic, avoiding the obvious bias of recruitment by health care facilities. Furthermore, 9 (3.5%), 19 (7.5%), and 8 (3.2%) study participants were HIV-, HBsAg-, and HCV-specific antibody positive, respectively, in accordance with the high endemicity of these three major chronic viral infections in Chad [48, 49]. However, our study has limitations.…”

Section: Discussionmentioning

confidence: 71%

Accuracy of Curable Sexually Transmitted Infections and Genital Mycoplasmas Screening by Multiplex Real-Time PCR Using a Self-Collected Veil among Adult Women in Sub-Saharan Africa

Nodjikouambaye

Compain

Sadjoli

et al. 2019

Infectious Diseases in Obstetrics and Gynecology

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Background. Sexually transmitted infections (STIs) are highly prevalent in sub-Saharan Africa. Genital self-sampling may facilitate the screening of STIs in hard-to-reach remote populations far from large health care centers and may increase screening rates. The cross-sectional GYNAUTO-STI study was carried out to assess the performance of a novel genital veil (V-Veil-Up Gyn Collection Device, V-Veil-Up Pharma, Ltd., Nicosia, Cyprus) as a genital self-sampling device to collect genital secretions to diagnose STIs by molecular biology as compared to reference clinician-collected genital specimens, in adult African women. Methods. Adult women living in N’Djamena, the capital city of Chad, were recruited from the community and referred to the clinic for women’s sexual health “La Renaissance Plus”. A clinician obtained an endocervical specimen using flocked swab. Genital secretions were also obtained by self-collection using veil. Both clinician- and self-collected specimens were tested for common curable STIs (including Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis) and genital Mycoplasma spp. by multiplex real-time PCR (Allplex™ STI Essential Assay, Seegene, Seoul, South Korea). Test positivities for both collection methods were compared by assessing methods agreement, sensitivity, and specificity. Results. A total of 251 women (mean age, 35.1 years) were prospectively enrolled. Only seven (2.8%) women were found to be infected with at least one common STIs [C. trachomatis: 3 (1.2%), N. gonorrhoeae: 1 (0.4%), M. genitalium: 4 (1.6%) and T. vaginalis: 1 (0.4%)], while the prevalence of genital mycoplasmas was much higher (54.2%) with a predominance of Ureaplasma parvum (42.6%). Self-collection by veil was non-inferior to clinician-based collection for genital microorganisms DNA molecular testing, with “almost perfect” agreement between both methods, high sensitivity (97.0%; 95%CI: 92.5-99.2%), and specificity (88.0%; 95%CI: 80.7-93.3%). Remarkably, the mean total number of genital microorganisms detected per woman was 1.14-fold higher in self-collected specimens compared to that in clinician-collected specimens. Conclusions. Veil-based self-collection of female genital secretions constitutes a convenient tool to collect in gentle way cervicovaginal secretions for accurate molecular detection of genital bacteria. Such sampling procedure could be easily implemented in STIs clinics in sub-Saharan Africa.

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“…This same coinfection was reported with HBsAg-Syphilis by Nambei et al with 12.5% and that of HIV and HCV which were respectively 12.5%, but this prevalence remains higher than that obtained in our study. In 2014, Bessimbaye et al [18] in Chad reported a prevalence of HBsAg at 13.5% in people infected with HIV. This suggests that the prevalence of HBsAg is significantly elevated in blood donors and in the general population.…”

Section: Resultsmentioning

confidence: 99%

Syphilis Seroprevalence among Blood Donors at the Chad National Blood Transfusion Center in N’Djamena

Mbanga

Nadlaou

Moussa

et al. 2021

JAMMR

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This involves evaluating the risk of syphilis transfusion in blood donors having a reaction to the group antigen and confirming positive or negative by the treponemal test. From August 2019 to August 2020, an observational study of syphilitic markers was conducted with blood donors (replacement families and volunteers non-remunerated) at the Center National de Transfusion Sanguine de N’Djamena. The donors included were also tested negative for the markers (HBsAg, Ab anti HCV, Ag /Ab HIV) according to standard methods of clinical microbiology. During one year, 24587 donors were identified of which 654 (2.65%) were confirmed positive by the treponemal test. Different positive rates of syphilis were determined in family replacement donors (94%), voluntary non-remunerated donors (6.12%), male (86%) and female (13%) respectively. This study determined a level of specific antigen for syphilis in a study population that reacted positively to the non-treponemal test. In view of this result, we recommend screening with the treponemal test in any blood donor having a reaction with a non-treponemal test in order to minimize the residual risk of transmission of syphilis among blood donors in Chad.

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Séroprévalence de l’Ag HBs et de l’anticorps Anti VHC chez les personnes infectées par le VIH1 à N’Djamena, Tchad

Cited by 12 publications

References 10 publications

High prevalence of cervical high-risk human papillomavirus infection mostly covered by Gardasil-9 prophylactic vaccine in adult women living in N’Djamena, Chad

High prevalence of cervical high-risk human papillomavirus infection mostly covered by Gardasil-9 prophylactic vaccine in adult women living in N’Djamena, Chad

Accuracy of Curable Sexually Transmitted Infections and Genital Mycoplasmas Screening by Multiplex Real-Time PCR Using a Self-Collected Veil among Adult Women in Sub-Saharan Africa

Syphilis Seroprevalence among Blood Donors at the Chad National Blood Transfusion Center in N’Djamena

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