TBX3, a downstream target of TGF-β1, inhibits mesangial cell apoptosis

Wensing, Lislaine A.; Campos, Alexandre

doi:10.1016/j.yexcr.2014.08.022

Cited by 12 publications

(12 citation statements)

References 56 publications

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“…Finally, they showed that the TGF-β1/TBX3/TBX2 axis resulted in the upregulation of p21WAF1, leading to cell cycle inhibition. Recent work by Wensing & Campos also showed that TGF-β1 treatment of immortalised human mesangial cells resulted in a substantial increase in TBX3 and TBX3+2a mRNA which resulted in the evasion of serum starvation-triggered apoptosis (48). These findings suggest that TGF-β1 may upregulate TBX3 to simultaneously inhibit proliferation but bypass apoptosis.…”

Section: Transforming Growth Factor-beta 1 (Tgf-β1) Signalling Pathwaymentioning

confidence: 89%

“…Indeed, head and neck squamous cell carcinoma (HNSCC) cells depleted of TBX3 underwent anoikis (7). The overexpression of TBX3 or TBX3+2a in kidney mesangial cells was also reported to result in the evasion of serum starvationtriggered apoptosis (48). Furthermore, silencing Tbx3 in rat bladder carcinoma cells rendered the cells sensitive to doxorubicin-induced apoptosis and the overexpression of TBX3 was associated with a chemotherapy-resistant phenotype (49).…”

Section: Tbx3 In Senescence Apoptosis and Proliferationmentioning

confidence: 98%

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The T-Box transcription factor 3 in development and cancer

Willmer

Cooper

Peres

et al. 2017

BST

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Section: Transforming Growth Factor-beta 1 (Tgf-β1) Signalling Pathwaymentioning

confidence: 89%

Section: Tbx3 In Senescence Apoptosis and Proliferationmentioning

confidence: 98%

The T-Box transcription factor 3 in development and cancer

Willmer

Cooper

Peres

et al. 2017

BST

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“…It has been well established that Tbx3 participates in the regulation of the cell cycle (16). In order to investigate the role of Tbx3 in regulating the cell cycle, flow cytometry was performed to determine whether Tbx3 overexpression affects the cell cycle of A549 and NCI-H460 cells.…”

Section: Downregulation Of Tbx3 Affects the Distribution Of Cell Cyclmentioning

confidence: 99%

T-box 3 overexpression is associated with poor prognosis of non-small cell lung cancer

Jiang

Zhang

2017

Oncology Letters

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Abstract. T-box 3 (Tbx3), a member of the T-box transcription factor family, serves a crucial role in embryonic development and cancer progression. Previous studies have demonstrated the clinical significance of Tbx3 in numerous types of cancer. However, the expression level and pathological function of Tbx3 in non-small cell lung cancer (NSCLC) are unknown. To the best of our knowledge, the present study provided the first evidence demonstrating the clinicopathological significance of Tbx3 in NSCLC. Tbx3 was revealed to be overexpressed in NSCLC cell lines and tissues obtained from patients with NSCLC by reverse transcription-quantitative polymerase chain reaction and western blot analysis. Downregulation of Tbx3 by Tbx3-specific short hairpin RNA decreased cell proliferation in NSCLC cell lines, but there was a slight increase in the cell population of the G 1 phase. Furthermore, depletion of Tbx3 expression significantly decreased the cell migration distance. In addition, overexpression of Tbx3 was notably associated with tumor size, tobacco smoking status, tumor-node-metastasis stage and differentiation. These results demonstrated the importance of Tbx3 in the pathological progression of NSCLC and may serve as a potential therapeutic target for NSCLC.

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“…12 Studies demonstrated that early hyperglycemia stimulates the production of ECM components, mainly fibronectin and collagen IV, and this effect appears to be mediated by transforming growth factor beta 1 (TGF-b1) in streptozotocin (STZ)-induced diabetic rats, 13,14 as well as, in other models of renal injury. 15,16 Currently, no specific therapy is available to inhibit the progression of renal diabetic disease, and although some studies have demonstrated the renoprotective action of pharmacological therapies that target the glycemic and blood pressure controls, 17,18 the incidence of diabetic nephropathy continues to increase. 1 Regular exercise training is considered an unquestionable component of a healthy lifestyle and widely accepted in the management and prevention of several chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats

Amaral

Silva

Correia

et al. 2015

Exp Biol Med (Maywood)

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This study evaluated the effects of aerobic exercise performed both previously and after the induction of diabetes mellitus on changes of renal function and structure in streptozotocin-induced diabetic rats. Female wistar rats were divided into five groups:The previous exercise consisted of treadmill running for four weeks before the induction of diabetes mellitus. After induction of diabetes mellitus with streptozotocin, the D þ PEx, D þ Ex and C þ Ex groups were submitted to eight weeks of aerobic exercise. At the end of the training protocol, we evaluate the serum glucose, insulin and 17b-estradiol levels, renal function and structure, proteinuria, and fibronectin, collagen IV and transforming growth factor beta 1 (TGF-b1) renal expressions. Induction of diabetes mellitus reduced the insulin and did not alter 17b-estradiol levels, and exercise did not affect any of these parameters. Previous exercise training attenuated the loss of body weight, the blood glucose, the increase of glomerular filtration rate and prevented the proteinuria in the D þ PEx group compared to D þ Se group. Previous exercise also reduced glomerular hypertrophy, tubular and glomerular injury, as well as the expressions of fibronectin and collagen IV. These expressions were associated with reduced expression of TGF-b1. In conclusion, our study shows that regular aerobic exercise especially performed previously to induction of diabetes mellitus improved metabolic control and has renoprotective action on the diabetic kidney.

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TBX3, a downstream target of TGF-β1, inhibits mesangial cell apoptosis

Cited by 12 publications

References 56 publications

The T-Box transcription factor 3 in development and cancer

The T-Box transcription factor 3 in development and cancer

T-box 3 overexpression is associated with poor prognosis of non-small cell lung cancer

Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats

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