On the relevance of the NPY2-receptor variation for modes of action cascading processes

Beste, Christian; Stock, Ann‐Kathrin; Epplen, Jörg T.; Arning, Larissa

doi:10.1016/j.neuroimage.2014.08.026

Cited by 14 publications

(14 citation statements)

References 43 publications

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“…This interpretation seems particularly poignant for the SCD0 condition, in which TBS protocols showed differential effects. As discussed in previous studies 21 , the more that participants attempt to simultaneously process the 'stop-goal' and the 'change-goal', the stronger the interference between these goals at a strategic response selection bottleneck 3 . Inhibitory control processes that manage the stopping of a response are likely to be intensified as a result of stronger interference.…”

Section: Discussionmentioning

confidence: 75%

“…This was evidenced by the fact that P3 was modulated by TBS while the visual and auditory P1 and N1 (reflecting attentional selection processes) were unaffected 1,21 . In this context, a larger P3 amplitude was associated with a less efficient processing strategy 1,21 . In the stop-change paradigm used in the present experiments, P3 likely reflects behavioural inhibition and change processes.…”

Section: Discussionmentioning

confidence: 99%

“…Further, Ness and Beste 32 reported MNI coordinates of the rIFG activated during an identical stopchange task executed during functional magnetic resonance imaging. Because we aimed to investigate the processes related to response selection, we calculated the mean rIFG MNI coordinates using the ventral rIFG MNI coordinates reported by Verbruggen et al 14 21,8]) was then converted to and marked on participants' individual reconstructed right-brain hemispheres in Talairach space. Second, we optimized the individual fit with regard to anatomical landmarks to ensure the stimulation of the ventral rIFG.…”

Section: Methodsmentioning

confidence: 99%

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A causal role of the right inferior frontal cortex in implementing strategies for multi-component behaviour

2015

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Everyday activities, such as, for example, driving a car or preparing a meal, require the hierarchical organization and processing of several individual actions. Currently, the neural mechanisms underlying the control of action sequences are not well understood. Here, the authors demonstrate that the right inferior frontal gyrus (rIFG) plays a key role in implementing the strategy used to cascade different actions. Continuous theta burst stimulation (TBS) applied to the rIFG results in a less efficient action cascading strategy, whereas intermittent TBS results in a more efficient strategy, compared with a shamTBS control condition. These effects are confirmed in electrophysiological data showing that activity differences in the rIFG are related to alterations in response selection processes. Overall, these results suggest that the neural dynamics of the rIFG determine the strategy used during some forms of everyday multi-component behaviour.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A causal role of the right inferior frontal cortex in implementing strategies for multi-component behaviour

2015

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“…Data processing involved standard preprocessing steps completed as in previous studies using the Go/Nogo paradigm 25 and the Flanker paradigm. 26,27 The error-related negativity (ERN) and correct-related negativity were examined after the error response 28 at the fronto-central electrode sites. The Nogo-N2 and Nogo-P3 were also E X E C U T I V E F U N C T I O N I N X D P quantified at electrodes FCz and Cz, and chosen electrode sites were validated.…”

Section: Eeg Recording and Analysesmentioning

confidence: 99%

Striosomal dysfunction affects behavioral adaptation but not impulsivity—Evidence from X‐linked dystonia‐parkinsonism

Beste

Mückschel

Rosales³

et al. 2017

Movement Disorders

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This dissociable pattern of cognitive deficits most likely reflects predominant dysfunction of the striosomal compartment and its connections to the anterior cingulate cortex in X-linked dystonia-parkinsonism. The results underscore the importance of striosomes for cognitive function in humans and suggest that striosomes are relays of error-related behavioral adaptation but not inhibitory control. © 2017 International Parkinson and Movement Disorder Society.

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“…Cognitive branching mechanisms may be more necessary in the bimodal condition, because here, information from different modalities needs to be integrated and put in order for action cascading. However, previous results suggest that the anterior cingulate cortex (ACC) plays a role in action cascading, too 7 10 24 . It is therefore possible that differences between conditions in the P3 are also related to activity changes in the ACC.…”

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confidence: 99%

The importance of sensory integration processes for action cascading

Gohil

Stock

Beste

2015

Sci Rep

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Dual tasking or action cascading is essential in everyday life and often investigated using tasks presenting stimuli in different sensory modalities. Findings obtained with multimodal tasks are often broadly generalized, but until today, it has remained unclear whether multimodal integration affects performance in action cascading or the underlying neurophysiology. To bridge this gap, we asked healthy young adults to complete a stop-change paradigm which presented different stimuli in either one or two modalities while recording behavioral and neurophysiological data. Bimodal stimulus presentation prolonged response times and affected bottom-up and top-down guided attentional processes as reflected by the P1 and N1, respectively. However, the most important effect was the modulation of response selection processes reflected by the P3 suggesting that a potentially different way of forming task goals operates during action cascading in bimodal vs. unimodal tasks. When two modalities are involved, separate task goals need to be formed while a conjoint task goal may be generated when all stimuli are presented in the same modality. On a systems level, these processes seem to be related to the modulation of activity in fronto-polar regions (BA10) as well as Broca's area (BA44).

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On the relevance of the NPY2-receptor variation for modes of action cascading processes

Cited by 14 publications

References 43 publications

A causal role of the right inferior frontal cortex in implementing strategies for multi-component behaviour

A causal role of the right inferior frontal cortex in implementing strategies for multi-component behaviour

Striosomal dysfunction affects behavioral adaptation but not impulsivity—Evidence from X‐linked dystonia‐parkinsonism

The importance of sensory integration processes for action cascading

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