Diagnostic Role of Magnetic Resonance Imaging in Assessing Orofacial Pain and Paresthesia

Ohba, Seigo; Yoshimura, Hitoshi; Matsuda, Shinpei; Kobayashi, Jun’ichi; Kimura, Takashi; Aiki, Minako; Sano, Kazuo

doi:10.1097/scs.0000000000001000

Cited by 4 publications

(1 citation statement)

References 19 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite such findings, currently, there is no evidence of the request for MRI in patients with COFP. Structural MRI is a common screening tool used by clinicians in the differential diagnosis of several types of COFP in order to exclude structural lesions, such as intracranial tumors and cysts, or any vascular compression of the trigeminal nerve ( Ohba et al, 2014 ; Devine et al, 2019 ). In a recent study of Devine et al (2019) on 125 patients with different types of COFP, except BMS, the authors found no alteration in the MRI scan in 51.2% of patients.…”

Section: Discussionmentioning

confidence: 99%

White matter hyperintensities in Burning Mouth Syndrome assessed according to the Age-Related White Matter Changes scale

Adamo

Canfora

Calabria

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

BackgroundWhite matter hyperintensities (WMHs) of the brain are observed in normal aging, in various subtypes of dementia and in chronic pain, playing a crucial role in pain processing. The aim of the study has been to assess the WMHs in Burning Mouth Syndrome (BMS) patients by means of the Age-Related White Matter Changes scale (ARWMCs) and to analyze their predictors.MethodsOne hundred BMS patients were prospectively recruited and underwent magnetic resonance imaging (MRI) of the brain. Their ARWMCs scores were compared with those of an equal number of healthy subjects matched for age and sex. Intensity and quality of pain, psychological profile, and blood biomarkers of BMS patients were further investigated to find potential predictors of WMHs. Specifically, the Numeric Rating Scale (NRS), Short-Form McGill Pain Questionnaire (SF-MPQ), Hamilton rating scale for Depression and Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) were administered.ResultsThe BMS patients presented statistically significant higher scores on the ARWMCs compared to the controls, especially in the right frontal, left frontal, right parietal-occipital, left parietal-occipital, right temporal and left temporal lobes (p-values: <0.001, <0.001, 0.005, 0.002, 0.009, 0.002, and <0.001, respectively). Age, a lower educational level, unemployment, essential hypertension, and hypercholesterolemia were correlated to a higher total score on the ARWMCs (p-values: <0.001, 0.016, 0.014, 0.001, and 0.039, respectively). No correlation was found with the blood biomarkers, NRS, SF-MPQ, HAM-A, HAM-D, PSQI, and ESS.ConclusionPatients with BMS showed a higher frequency of WMHs of the brain as suggested by the higher ARWCs scores compared with the normal aging of the healthy subjects. These findings could have a role in the pathophysiology of the disease and potentially affect and enhance pain perception.

show abstract

Section: Discussionmentioning

confidence: 99%