Reduced CD200 and CD200R1 expression in human chorionic villi contributes to early spontaneous abortion

Abstract

There is an increase in inhibitory properties of human chorionic villi during normal pregnancy. The mechanism underlying ESA might be associated with enhanced expression of CD200 and CD200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy.

Changes in expression of theCD200 tolerance‐signaling molecule and its receptor (CD200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis

“…12 Syncytiotrophoblast CD200 could have an autocrine self-stimulating effect as well as paracrine effects on CD200R + cytotrophoblasts. 12 Syncytiotrophoblast CD200 could have an autocrine self-stimulating effect as well as paracrine effects on CD200R + cytotrophoblasts.…”

“…12 Based on CD200 −/− mouse data, CD200 exerts potent anti-inflammatory and anti-autoimmune effects which includes suppression of IL-17producing cells. However, a reduction in CD200R1 in villus syncytiotrophoblasts and villus cytotrophoblasts was more dramatic so CD200/CD200R1 ratios increased.…”

The Receptor for the CD200 Tolerance‐Signaling Molecule Associated with Successful Pregnancy is Expressed by Early‐Stage Breast Cancer Cells in 80% of Patients and by Term Placental Trophoblasts

“…6 Human term placental trophoblast cells express CD200, and recently, Wang et al have reported CD200 expression on villous trophoblasts from healthy first trimester pregnancies, and a reduced expression on spontaneous abortion trophoblasts. 7,8 Wang et al also reported the presence of CD200R1 on first trimester villous trophoblasts from healthy pregnancies and reduced expression on miscarriage tissue. 8 The study by Wang et al is the first to suggest that CD200R1 might be expressed on nonlymphomyeloid cells in humans.…”

“…7,8 Wang et al also reported the presence of CD200R1 on first trimester villous trophoblasts from healthy pregnancies and reduced expression on miscarriage tissue. 8 The study by Wang et al is the first to suggest that CD200R1 might be expressed on nonlymphomyeloid cells in humans.…”

“…The anti-CD200 and anti-CD200R1 staining of breast cancer cells shown in the present study is probably real since in separate studies using our antibodies we obtained similar staining of 5-week gestation villous trophoblasts as recently reported by Wang et al (data not shown). 8 CD200 was originally described as suppressing activity of brain microglia which are macrophage-like cells. 1,17 Trophoblasts may also behave in an invasive and phagocytic manner, 18 and it is tempting to speculate CD200 might inhibit CD200R1 + trophoblast proliferation and motility as pregnancy progresses.…”