Progenitor genealogy in the developing cerebral cortex

Laguesse, Sophie; Peyre, Elise; Nguyen, Laurent

doi:10.1007/s00441-014-1979-5

Cited by 25 publications

(16 citation statements)

References 168 publications

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“…The historical status of this particular configuration is hypothetical. However, it is consistent with findings from cnidarians (Satterlie, 2011 ), while it is also clear that such chemical signaling and in particular chemical synapses are an essential feature for the operation of modern nervous systems in clades that diverged early in evolution (Moroz, 2014 ). The evolutionary origin of chemical synapses is a subject of ongoing research (Sakarya et al, 2007 ; Ryan and Grant, 2009 ; Emes and Grant, 2012 ).…”

Section: Introductionsupporting

confidence: 85%

Modeling spontaneous activity across an excitable epithelium: Support for a coordination scenario of early neural evolution

Wiljes

Elburg

Biehl

et al. 2015

Front. Comput. Neurosci.

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Internal coordination models hold that early nervous systems evolved in the first place to coordinate internal activity at a multicellular level, most notably the use of multicellular contractility as an effector for motility. A recent example of such a model, the skin brain thesis, suggests that excitable epithelia using chemical signaling are a potential candidate as a nervous system precursor. We developed a computational model and a measure for whole body coordination to investigate the coordinative properties of such excitable epithelia. Using this measure we show that excitable epithelia can spontaneously exhibit body-scale patterns of activation. Relevant factors determining the extent of patterning are the noise level for exocytosis, relative body dimensions, and body size. In smaller bodies whole-body coordination emerges from cellular excitability and bidirectional excitatory transmission alone. Our results show that basic internal coordination as proposed by the skin brain thesis could have arisen in this potential nervous system precursor, supporting that this configuration may have played a role as a proto-neural system and requires further investigation.

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Section: Introductionsupporting

confidence: 85%

Modeling spontaneous activity across an excitable epithelium: Support for a coordination scenario of early neural evolution

Wiljes

Elburg

Biehl

et al. 2015

Front. Comput. Neurosci.

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“…Although the molecular mechanisms that control this transition from direct to indirect neurogenesis during embryonic development remain to be clarified, accumulating reports have demonstrated the unfolded protein response (UPR) within the endoplasmic reticulum (ER) of aRGs to be a key modulatory factor (reviewed in Laguesse et al . , Dwyer et al . ).…”

Section: Factors Influencing Symmetric Versus Asymmetric Divisionmentioning

confidence: 99%

Cortical progenitor biology: key features mediating proliferation versus differentiation

Uzquiano

Gladwyn-Ng

Nguyen

et al. 2018

Journal of Neurochemistry

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The cerebral cortex is a highly organized structure whose development depends on diverse progenitor cell types, namely apical radial glia, intermediate progenitors, and basal radial glia cells, which are responsible for the production of the correct neuronal output. In recent years, these progenitor cell types have been deeply studied, particularly basal radial glia and their role in cortical expansion and gyrification. We review here a broad series of factors that regulate progenitor behavior and daughter cell fate. We first describe the different neuronal progenitor types, emphasizing the differences between lissencephalic and gyrencephalic species. We then review key factors shown to influence progenitor proliferation versus differentiation, discussing their roles in progenitor dynamics, neuronal production, and potentially brain size and complexity. Although spindle orientation has been considered a critical factor for mode of division and daughter cell output, we discuss other features that are emerging as crucial for these processes such as organelle and cell cycle dynamics. Additionally, we highlight the importance of adhesion molecules and the polarity complex for correct cortical development. Finally, we briefly discuss studies assessing progenitor multipotency and its possible contribution to the production of specific neuronal populations. This review hence summarizes recent aspects of cortical progenitor cell biology, and pinpoints emerging features critical for their behavior.

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“…Several signaling pathways have been associated with the choice made by cycling APs between symmetric proliferative division (generation of AP daughters) and asymmetric differentiative division (generation of neuron or IP) (Laguesse et al, 2015). However, the molecular basis of the cell fate decision of dividing AP to become either neuron or IP remains poorly understood.…”

Section: Loss Of Elongator Expression Hampers Translationmentioning

confidence: 99%

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis

et al. 2015

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The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-related progenitors. At the onset of corticogenesis, the first-born progenitors are apical progenitors (APs), whose asymmetric division gives birth directly to neurons. Later, they switch to indirect neurogenesis by generating intermediate progenitors (IPs), which give rise to projection neurons of all cortical layers. While a direct lineage relationship between APs and IPs has been established, the molecular mechanism that controls their transition remains elusive. Here we show that interfering with codon translation speed triggers ER stress and the unfolded protein response (UPR), further impairing the generation of IPs and leading to microcephaly. Moreover, we demonstrate that a progressive downregulation of UPR in cortical progenitors acts as a physiological signal to amplify IPs and promotes indirect neurogenesis. Thus, our findings reveal a contribution of UPR to cell fate acquisition during mammalian brain development.

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Progenitor genealogy in the developing cerebral cortex

Cited by 25 publications

References 168 publications

Modeling spontaneous activity across an excitable epithelium: Support for a coordination scenario of early neural evolution

Modeling spontaneous activity across an excitable epithelium: Support for a coordination scenario of early neural evolution

Cortical progenitor biology: key features mediating proliferation versus differentiation

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis

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