Associations between central obesity and asthma in children and adolescents: a case–control study

Papoutsakis, Constantina; Chondronikola, Maria; Antonogeorgos, Georgios; Papadakou, Eleni; Matziou, Vasiliki; Drakouli, Maria; Konstantaki, Evanthia; Papadimitriou, Anastasios; Priftis, Kostas Ν.

doi:10.3109/02770903.2014.954291

Cited by 25 publications

(34 citation statements)

References 25 publications

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“…The most common parameter related to asthma risk in the obese paediatric population is having a weight over the ninetieth percentile for their age [5][6][7][8][9]. The obesity definition using Body Mass Index-Z by the World Health Organization is also linked to a higher risk of asthma [10,11]. Benedetti et al state that this risk is three times higher than in the nonobese population.…”

Section: Obesity Indicators Relation With Asthmamentioning

confidence: 99%

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Asthma and Obesity during Childhood: A Review of More than an Occasional Association

Rocha¹,

Machado²

2017

J Preg Child Health

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Section: Obesity Indicators Relation With Asthmamentioning

confidence: 99%

“…A Waist-toHeight ratio of over zero point forty-three is concomitant with a higher risk of asthma [10,11]. According to Benedetti et al this risk is one point twenty-four times higher.…”

Section: Obesity Indicators Relation With Asthmamentioning

confidence: 99%

Asthma and Obesity during Childhood: A Review of More than an Occasional Association

Rocha¹,

Machado²

2017

J Preg Child Health

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“…Additionally, in 45 patients who underwent a standardized fatty meal test and whose triglycerides levels were subsequently measured after 2, 4, 6 and 8 hours, it was shown that high post-challenge triglycerides correlated positively with an increase in aortic pulse wave velocity (aPWV) 6 hours after the fatty meal consumption and, specifically, a 0.88 m/s rise of aPWVA was found for a 100mg/dl increase in triglycerides. 80 Waist circumference, which is an index of central obesity, constitutes a well-recognized cardiovascular risk factor in hypertensive patients 55 and has also been reported to be associated with such conditions as, inter alia, idiopathic portal vein thrombosis, 81 asthma in children and adolescents and uncontrolled asthma in women, 82,83 non-alcoholic liver disease 84 and dementia. 85 Oka et al conducted a study including 1,505 men and 798 women who were not taking medications for diabetes or dyslipidemia.…”

Section: Nordestgaard Et Al 2007mentioning

confidence: 99%

Postprandial dysmetabolism: Too early or too late?

Pappas¹,

Kandaraki²,

Tsirona³

et al. 2016

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postprandial dysmetabolism is a postprandial state characterized by abnormal metabolism of glucose and lipids and, more specifically, of elevated levels of glucose and triglyceride (Tg) containing lipoproteins. Since there is evidence that postprandial dysmetabolism is associated with increased cardiovascular mortality and morbidity, due to macro-and microvascular complications, as well as with conditions such as polycystic ovary syndrome (pCOS) and nonalcoholic fatty liver disease (NaFlD), it is recommended that clinicians be alert for early detection and management of this condition. management consists of a holistic approach including dietary modification, exercise and use of hypoglycemic and hypolipidemic medication aiming to decrease the postprandial values of circulating glucose and triglycerides. This review aims to explain glucose and lipid homeostasis and the impact of postprandial dysmetabolism on the cardiovascular system as well as to offer suggestions with regard to the therapeutic approach for this entity. however, more trials are required to prevent or reverse early and not too late the actual tissue damage due to postprandial dysmetabolism.

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“…Moreover, this constellation of pulmonary function abnormalities suggests that alteration in airway caliber, potentially due to altered diaphragmatic movement, rather than inherent airway hyper‐responsiveness, underlies the obese asthma phenotype . This speculation is supported by a greater contribution of truncal adiposity as compared with general adiposity to disease burden and pulmonary function abnormalities in obese asthmatics …”

Section: Pulmonary Function Deficits In Obesity‐related Asthma and Thmentioning

confidence: 99%

“…[59][60][61][62] This speculation is supported by a greater contribution of truncal adiposity as compared with general adiposity to disease burden and pulmonary function abnormalities in obese asthmatics. 63,64 Associations between systemic nonatopic Th1 polarized immune patterns with pulmonary function deficits have been reported in obese children with asthma. While FEV 1 /FVC ratio inversely correlated with circulating biomarkers of Th1 inflammation, including interferon-γ and interferon-γ-induced protein-10, in obese asthmatic preadolescents, 51 systemic Th1 polarization inversely correlated with RV, RV/TLC ratio, and FRC in adolescents Figure 1.…”

Section: Pulmonary Function Deficits In Obesity-related Asthma and mentioning

confidence: 99%

Pediatric obesity‐related asthma: A prototype of pediatric severe non‐T2 asthma

Rastogi

2020

Pediatric Pulmonology

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Childhood obesity contributes to many diseases, including asthma. There is literature to suggest that asthma developing as a consequence of obesity has a nonallergic or non‐T2 phenotype. In this review, obesity‐related asthma is utilized as a prototype of non‐T2 asthma in children to discuss several nonallergic mechanisms that underlie childhood asthma. Obesity‐related asthma is associated with systemic T helper (Th)1 polarization occurring with monocyte activation. These immune responses are mediated by insulin resistance and dyslipidemia, metabolic abnormalities associated with obesity, that are themselves associated with pulmonary function deficits in obese asthmatics. As in other multifactorial diseases, there is both a genetic and an environmental contribution to pediatric obesity‐related asthma. In addition to genetic susceptibility, differential DNA methylation is associated with non‐T2 immune responses in pediatric obesity‐related asthma. Initial investigations into the biology of non‐T2 immune responses have identified the upregulation of genes in the CDC42 pathway. CDC42 is a RhoGTPase that plays a key role in Th cell physiology, including preferential naïve Th cell differentiation to Th1 cells, and cytokine production and exocytosis. Although these novel pathways are promising findings to direct targeted therapy development for obesity‐related asthma to address the disease burden, there is evidence to suggest that dietary interventions, including diet modification, rather than caloric restriction alone, decrease disease burden. Adoption of a diet rich in micronutrients, including carotenoids and 25‐OH cholecalciferol, a vitamin D metabolite, may be beneficial since these are positively correlated with pulmonary function indices, while being protective against metabolic abnormalities associated with the obese asthma phenotype.

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Associations between central obesity and asthma in children and adolescents: a case–control study

Cited by 25 publications

References 25 publications

Asthma and Obesity during Childhood: A Review of More than an Occasional Association

Asthma and Obesity during Childhood: A Review of More than an Occasional Association

Postprandial dysmetabolism: Too early or too late?

Pediatric obesity‐related asthma: A prototype of pediatric severe non‐T2 asthma

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