Meta-analysis of circulating 25-hydroxyvitamin D levels and risk of cardiovascular and all-cause mortality in elderly population

Fan, Hongjie; Yu, Weidong; Cao, Hui; Li, Jun; Liu, Bing; Wang, Junpeng; Shao, Yang; Fan, Yingcai; Jun, Yang; Zhang, Qiang; Hu, Xinhua

doi:10.1016/j.ijcard.2014.07.074

Cited by 17 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, there was no association between the circulating levels of 25(OH)D and genotypes of rs4588/rs7041. Low circulating levels of 25(OH)D have been linked with the increased risk of CAD, and this relation may differ in various populations (9, 10, 11, 12, 13, 14, 15, 16, 17). Ethnic variations in VDBP polymorphisms might be responsible for the altered bioavailability (25, 28).…”

Section: Discussionmentioning

confidence: 99%

“…In spite of sufficient treatments, patients have a considerable mortality rate (7). A number of meta-analyses on prospective and interventional studies have constantly indicated that low circulating 25-hydroxy vitamin D (25(OH)D) points to increased risk of cardiovascular disease and its consequent mortality (9, 10, 11, 12, 13, 14, 15, 16, 17). Studies also reported that the active form of vitamin D is absolutely involved in the regulation of the renin angiotensin aldosterone system and immune system (18).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: a Case-Control Study

Tarighi

Najafi

Hossein–Nezhad

et al. 2017

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Uvod: Koronarna arterijska bolest (CAD) jedno je od najrasprostranjenijih hroni~nih oboljenja. Vitamin D-vezuju}i protein (VDBP) i njegovi genetski polimorfizmi predo~eni su kao podlo`ne komponente za CAD. Cilj ove studije bio je da se ispita povezanost izme|u polimorfizama pojedina~nih nukleotida (SNPs) proteina VDBP -rs7041 i rs4588 i podlo` -nosti CAD u populaciji Iranaca. Metode: Ukupno 143 mu{karca sa CAD i 145 zdravih kontrolnih ispitanika odgovaraju}eg uzrasta i pola podvrgnuto je genotipizaciji za polimorfizme -rs7041 i rs4588 pomo}u metode lan~ane reakcije polimeraze odnosno polimorfizama du`ine restrikcionih fragmenata (PCR-RFLP). Nivo 25(OH)D u serumu odre|en je pomo}u kolorimetrijskog enzimskog imunoeseja na mikroplo~i. Rezultati: Otkrili smo zna~ajnu povezanost izme|u genotipa GG (rs7041) i CAD (p=0,02, OR=0,537 95% CI=0,306-0,944). [to se ti~e polimorfizma rs4588, uo~ena je zna~ajna razlika, pri ~emu su genotip CA (P=0,00032, OR=2,578, SummaryBackground: Coronary Artery Disease (CAD) is one of the most widespread non-communicable diseases. Vitamin Dbinding protein (VDBP) and its genetic poly morphisms have been highlighted as the susceptible components for CAD. The aim of the present study was to examine the association of VDBP single nucleotide poly morphisms (SNPs) -rs7041 and rs4588 -with CAD susceptibility among the Iranian population. Methods: A total of 143 men with CAD and 145 healthy age-sex matched controls underwent genotyping for thers7041 and rs4588 polymorphisms using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Serum level of 25(OH)D was assayed using microplate colorimetric enzyme immunoassay. Results: We found a significant association between GG genotype (rs7041) and CAD (p=0.02, OR=0.537 95% CI =0.306-0.944). Regarding rs4588 polymorphism, a significant difference was observed in which the CA genotype

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: a Case-Control Study

Tarighi

Najafi

Hossein–Nezhad

et al. 2017

Journal of Medical Biochemistry

View full text Add to dashboard Cite

show abstract

“…The effectiveness of vitamin D in preventing chronic diseases, including metabolic syndrome and cardiovascular diseases, has received extra attention in recent years [ 54 , 59 ]. Several studies suggested that vitamin D deficiency or insufficiency increases the risk of all-cause mortality in elderly participants, even before the onset of DM and cardiovascular diseases [ 60 ]. The result of a meta-analysis demonstrated that serum vitamin D levels of 75 to 87.5 nmol/L (or 30 to 35 ng/mL) are associated with the lowest mortality rate [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials

Qorbani

Zarei

Moradi

et al. 2022

Diabetol Metab Syndr

View full text Add to dashboard Cite

Background There has been a longstanding interest in the potential effect of vitamin D in preventing cardiac-metabolic diseases. However, there are divergent results regarding the impact of vitamin D supplementation (VDS) on managing cardiac-metabolic outcomes in the elderly population. Material and method We systematically searched electronic databases; Web of Science, PubMed, Scopus, EMBASE, Cochrane, and ProQuest. We included all trials that evaluated the effect of VDS on cardiac-metabolic risk factors in the elderly population, which were published until 30 September 2021. The effects of VDS on cardiac-metabolic outcomes were assessed using standardized mean difference (SMD). A random-effect model was used to pool the SMD and 95% confidence interval (CI). Result The literature search identified 4409 studies, of which 12 trials met inclusion criteria. Results of random effect meta-analysis indicated a significant reduction in total cholesterol (TC) (SMD: − 0.14 mg/dl; 95% CI: − 0.25, − 0.02) and triglyceride (TG) (SMD: − 0.45 mg/dl; 95% CI: − 0.86, − 0.04) with VDS compared to the placebo. The subgroup analyses revealed that the reduction of TG in patients with diabetes and vitamin D deficiency was significant. Furthermore, short-term intervention (≤ 6 months) induced a significantly lower level of TG and insulin in comparison to longer duration (> 6 months). Conclusion The study suggests that VDS could improve insulin concentration and dyslipidemia in the elderly population. The systematic review was registered in Alborz university of medical sciences with 2060-01-03-1397 number and the Ethics council IR.ABZUMS.REC.1397.207 number.

show abstract

“…Therefore, epidemiological data have to be taken into account as well. In a meta-analysis of prospective cohort studies based on more than 20,000 individuals [ 55 ], adjusted risk of cardiovascular mortality was 57% higher in the lowest 25OHD category than in the highest 25OHD category. The Whitehall study [ 56 ], a large prospective cohort study of older men living in the UK, indicates that higher concentrations of 25OHD are inversely and approximately linearly (log-log scale) associated with age- and season-adjusted vascular mortality throughout the range of 40–90 nmol/L.…”

Section: Vitamin D Deficiency Bone Disorders and Cardiovascular mentioning

confidence: 99%

The Biphasic Effect of Vitamin D on the Musculoskeletal and Cardiovascular System

Zittermann

2017

International Journal of Endocrinology

View full text Add to dashboard Cite

This narrative review summarizes beneficial and harmful vitamin D effects on the musculoskeletal and cardiovascular system. Special attention is paid to the dose-response relationship of vitamin D with clinical outcomes. In infants and adults, the risk of musculoskeletal diseases is highest at circulating 25-hydroxyvitamin D (25OHD) concentrations below 25 nmol/L and is low if 40–60 nmol/L are achieved. However, evidence is also accumulating that in elderly people the risk of falls and fractures increases again at circulating 25OHD levels > 100 nmol/L. Cohort studies report a progressive increase in cardiovascular disease (CVD) events at 25OHD levels < 50 nmol/L. Nevertheless, meta-analyses of randomized controlled trials suggest only small beneficial effects of vitamin D supplements on surrogate parameters of CVD risk and no reduction in CVD events. Evidence is accumulating for adverse vitamin D effects on CVD outcomes at 25OHD levels > 100 nmol/L, but the threshold may be influenced by the level of physical activity. In conclusion, dose-response relationships indicate deleterious effects on the musculoskeletal system and probably on the cardiovascular system at circulating 25OHD levels < 40–60 nmol/L and >100 nmol/L. Future studies should focus on populations with 25OHD levels < 40 nmol/L and should avoid vitamin D doses achieving 25OHD levels > 100 nmol/L.

show abstract

Meta-analysis of circulating 25-hydroxyvitamin D levels and risk of cardiovascular and all-cause mortality in elderly population

Cited by 17 publications

References 21 publications

Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: a Case-Control Study

Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: a Case-Control Study

Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials

The Biphasic Effect of Vitamin D on the Musculoskeletal and Cardiovascular System

Contact Info

Product

Resources

About