The impact of REACH on classification for human health hazards

Oltmanns, Jan; Bunke, Dirk; Jenseit, W.; Heidorn, Christian

doi:10.1016/j.yrtph.2014.08.005

Cited by 12 publications

(6 citation statements)

References 3 publications

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“…These observations suggest that the data generated under REACH lead to the classification of substances for endpoints that have not been previously covered. This finding supports earlier observations on a different dataset (Oltmanns et al, 2014). These authors analysed 142 chemicals produced at very high tonnages in the EU and found that 29 substances with harmonised classifications for human health endpoints were classified in REACH registration dossiers for at least one additional endpoint (i.e.…”

Section: Summary and Discussionsupporting

confidence: 86%

Final Report: Applying a tested procedure for the identification of potential emerging chemical risks in the food chain to the substances registered under REACH ‐ REACH 2

Oltmanns¹,

Bohlen²,

Escher

et al. 2019

EFS3

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This study applied a procedure for the identification of potential emerging chemical risks in the food chain to substances registered under the REACH Regulation that was previously developed and tested in an EFSA‐sponsored pilot study. The selection was limited to substances that (a) were registered with a full registration, (b) met eligibility criteria (e.g. availability of a CAS number and a SMILES notation) and (c) were considered to be inside the applicability domain of the models used in this study (excluding e.g. ionisable compounds and metals). This selection reduced the number of substances from about 15 000 to 2 336 substances that were subsequently assessed in four blocks: environmental releases (based on tonnage and use pattern), biodegradation (using BIOWIN predictions assessed in a battery approach), bioaccumulation in food/feed (using ACC‐HUMANsteady modelling) and toxicity (based on classification for carcinogenicity, mutagenicity, reprotoxicity and repeated dose toxicity). A scoring system was applied with a maximum score of 10 in each of the four blocks. The procedure showed a good degree of differentiation in each block. Two weighting scenarios and pivot table selections were applied to the scores in the four blocks. An evaluation of both approaches led to the prioritisation of substances for their potential to represent ‘emerging chemical risks’ in the food chain. Following additional curation steps, 212 ‘potential emerging risks’ were identified that are considered to (a) be released to the environment and/or poorly biodegraded, (b) bioaccumulate in food/feed and (c) represent a chronic human health hazard. In this study, in‐depth evaluations were performed for ten ‘potential emerging risks’ that so far have not been assessed by an EU regulatory body for their presence in food via the investigated exposure pathway. The selection of these ten substances does not imply that the remaining 202 potential emerging risks are of lower priority

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Section: Summary and Discussionsupporting

confidence: 86%

Final Report: Applying a tested procedure for the identification of potential emerging chemical risks in the food chain to the substances registered under REACH ‐ REACH 2

Oltmanns¹,

Bohlen²,

Escher

et al. 2019

EFS3

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“…This nding is in agreement with observations in a previous study on a different dataset. 69 This study did not differentiate the level of evidence for toxicity (see Materials and methods). For example, suspected and conrmed CMR substances were all assigned a Toxicity Score of 10.…”

Section: Evaluation Of the Four Blocks And Prioritisation Of Evaluatementioning

confidence: 94%

Potential emerging chemical risks in the food chain associated with substances registered under REACH

Oltmanns

Licht

Bohlen

et al. 2020

Environ. Sci.: Processes Impacts

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“…The United States manages mobile hazards through an information disclosure system requiring companies to accurately report hazardous chemicals' management. The EU has the world's largest substance classification database, the Chemical Classification and Labelling Catalogue, which can be used to identify and manage hazardous chemicals [43]. The United Nations Committee of Experts on the Transport of Dangerous Goods issued the "Recommendations on Model Regulations on the Transport of Dangerous Goods" to manage the transport of hazardous chemicals, providing a unified management framework for the safe transport of hazardous chemicals worldwide [44].…”

Section: Management Statusmentioning

confidence: 99%

Analysis of Accidents of Mobile Hazardous Sources on Expressways from 2018 to 2021

et al. 2022

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A total of 523 accident cases during 2018–2021 in China were studied in terms of accident year, region, road section, and time to reduce the probability of expressways mobile hazardous source transportation accidents. The characteristics and causes of accidents of moving hazardous sources on expressways are analyzed, and preventive measures are put forward. The results indicated that the number of expressways mobile hazardous source transportation accidents fluctuated less in the past four years. Provinces with a higher degree of industrialization are more prone to accidents, with 80.02% of accidents occurring on normal road sections. Summer is the high accident season and accidents are prone to occur at 7:00 and 8:00 every day. External factors cause 47.99% of accidents, liquid class mobile hazards quickly cause accidents, leakage accidents account for the heaviest proportion, and explosive accidents have the highest chance of causing secondary accidents. In order to reduce the probability of accidents, a comprehensive management framework suitable for the mobile hazard sources of expressways is proposed.

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The impact of REACH on classification for human health hazards

Cited by 12 publications

References 3 publications

Final Report: Applying a tested procedure for the identification of potential emerging chemical risks in the food chain to the substances registered under REACH ‐ REACH 2

Final Report: Applying a tested procedure for the identification of potential emerging chemical risks in the food chain to the substances registered under REACH ‐ REACH 2

Potential emerging chemical risks in the food chain associated with substances registered under REACH

Analysis of Accidents of Mobile Hazardous Sources on Expressways from 2018 to 2021

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