Retrospective case–control study of viral pathogen screening in proliferative verrucous leukoplakia lesions

García-López, Rodrigo; Moya, Andrés; Bagán, José

doi:10.1111/coa.12291

Cited by 15 publications

(20 citation statements)

References 17 publications

(24 reference statements)

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“…In the study published in 2008, EBV was found to be more prevalent in 10 PVL patients than in either OSCC or normal mucosa, whereas in the study published in 2016, EBV was found to be most prevalent in OSCC, and more prevalent in nine PVL patients than in normal mucosa. Oncoviruses (herpesvirus, papillomavirus, and polyomavirus) were not found in 10 PVL patients in study by García‐López et al…”

Section: Discussionmentioning

confidence: 89%

“…Fourteen studies included controls and compared their results with either normal oral mucosa, conventional oral leukoplakia, reactive lesions, or malignant tumors . Ten studies only analyzed biomarker expression (whether the biomarkers were present or not/strength of staining) . Four studies analyzed how biomarker expression was association with clinical and/or histological data .…”

Section: Resultsmentioning

confidence: 99%

“…Because heterogeneity was an issue, Gouvêa et al was excluded from further analysis. Five of the patient series were described from Spain . Bagan et al could possibly have overlapping patients, but because meta‐analysis was not done for EBV, this did not pose a problem in this review.…”

Section: Discussionmentioning

confidence: 99%

“…The reporting of tumor markers varied and was not rigorous. The sample size was often small, 10 studies included 10 or less PVL patients . Only five studies included 20 or more PVL patient cases .…”

Section: Discussionmentioning

confidence: 99%

“…Bagan et al could possibly have overlapping patients, but because meta‐analysis was not done for EBV, this did not pose a problem in this review. Bagan et al and García‐López et al both analyzed HPV in PVL and possibly have overlapping patients. Bagan et al do not specify where the patients were recruited from.…”

Section: Discussionmentioning

confidence: 99%

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Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta‐analysis

et al. 2018

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Background The aim was to update information on oral proliferative verrucous leukoplakia (PVL), a disease of verrucous‐like lesions with high risk of malignancy, and its biomarkers. Methods A systematic search of literature on PVL and its biomarkers showed 22 biomarkers that were investigated in 19 papers. A meta‐analysis was possible for human papillomavirus (HPV), aneuploidy, Ki‐67, and p53. Results Aneuploidy was found consistently (I2 = 0%, P = 0.61) in 92% (95% CI 80%‐99%) of the PVL cases. P53 positivity prevalence was 27% (95% CI 15%‐40%) in two available studies (I2 = 0%, P = 0.64). With HPV and Ki‐67, the most outlying studies needed to be removed and after that the pooled HPV positivity prevalence (I2 = 24%, P = 0.27) was 5% (95% CI 0%‐14%) and for Ki‐67 (I2 = 9%, P = 0.33) 14% (95% CI 6%‐26%). Conclusions With the evidence of the current literature, aneuploidy could value as a biomarker of PVL but should be further validated.

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Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta‐analysis

et al. 2018

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No detection of Merkel cell polyomavirus in oral lichen planus: Results of a preliminary study in a French cohort of patients

et al. 2017

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Oral lichen planus (OLP) is a chronic inflammatory disease considered as a CD8+ T lymphocyte-mediated autoimmune reaction, which may be triggered by undetermined virus. Recent reports have described the detection of Merkel cell polyomavirus (MCPyV) DNA in oral samples from healthy patients and in patients with different forms of oral cancers. We therefore investigated in a prospective way whether MCPyV was detectable in oral lesions of patients with active OLP. Our preliminary results do not support the hypothesis that OLP may be triggered by MCPyV infection. Further studies are needed to evaluate the involvement of other human polyomaviruses in OLP pathogenesis.

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Oral cancer on the gingiva in patients with proliferative leukoplakia: A study of 30 cases

Bagán

Murillo-Cortés

Leopoldo-Rodado

et al. 2019

Journal of Periodontology

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Background Proliferative verrucous leukoplakia, recently coined as proliferative leukoplakia (PL), is associated with a strong tendency to recur after treatment and an elevated rate of malignant transformation. We compared the clinical characteristics of patients with gingival PL with and without progression to oral squamous cell carcinoma. Methods The patients were divided into two groups: group 1 included 33 patients with gingival PL that did not progress to cancer, and group 2 included 30 patients with PL who developed malignant transformation during follow‐up. We compared age, sex, tobacco habit, clinical characteristics of gingival PL lesions, and location, tumor‐node‐metastasis (TNM) stage, and clinical characteristics of gingival malignancy between groups. Results Female sex was predominant in the group with gingival cancer, and simultaneous involvement of the buccal mucosa, tongue, and palate was more common in this group than in the group without cancer. PL lesions were also largest in the group of patients with cancer. Most gingival cancer occurred in areas with teeth and took the form of oral ulceration. TNM stage I was most common. Conclusions The simultaneous presence of lesions on the buccal mucosa, grade of lesion extension, and presence of ulcerative lesion were significantly associated with gingival cancer in patients with PL.

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Retrospective case–control study of viral pathogen screening in proliferative verrucous leukoplakia lesions

Abstract: No association between proliferative verrucous leukoplakia and target viruses was detected. A higher throughput viral metagenomic approach may prove valuable for future analyses, as it would not be restricted to a priori knowledge of potential targets.

Cited by 15 publications

References 17 publications

Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta‐analysis

Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta‐analysis

No detection of Merkel cell polyomavirus in oral lichen planus: Results of a preliminary study in a French cohort of patients

Oral cancer on the gingiva in patients with proliferative leukoplakia: A study of 30 cases

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