2509 Living Donor Nephrectomies, Morbidity and Mortality, Including the UK Introduction of Laparoscopic Donor Surgery

Hadjianastassiou, Vassilis G.; Rj, Johnson; Rudge, Chris; Mamode, Nizam

doi:10.1111/j.1600-6143.2007.01975.x

Cited by 78 publications

(40 citation statements)

References 28 publications

(33 reference statements)

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“…Its clinical and social significance has increased in recent years as the gap between needed and available donor organs has continuously been growing due to a decline in the number of cadaveric kidney donations [1] . The living kidney donation helps not only to reduce the number of patients waiting for an organ donation, but it also has -regarding the graft function -decisive advantages over the cadaveric kidney grafts [2,3] . Reasons for this include the reduction of waiting time for a donor organ resulting in decrease of morbidity in patients on waiting list, the comparatively short cold isch-Fornara Urol Int 2010;84:61-66 62 emia time, and due to the predictability of the operation, optimal immunosuppression of the recipient prior to transplantation [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Early and Late Graft Function after Laparoscopic Hand-Assisted Donor Nephrectomy for Living Kidney Transplantation: Comparison with Open Donor Nephrectomy

et al. 2010

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Background and Purpose: Laparoscopic donor nephrectomy has become the procedure of choice for living kidney transplantation in many centers. We report on our experience with laparoscopic hand-assisted donor nephrectomy, in particular concerning graft function compared with open donor nephrectomy. Materials and Methods: Between 1995 and March 2007, 72 patients with end-stage renal disease have received kidney transplantation from living donors. Open living donor nephrectomy (ODN) was performed in 35 donors, whereas 37 donors had undergone laparoscopic hand-assisted nephrectomy (HALDN). Immediate graft function, serum creatinine and serum cystatin C 1 year after the transplantation were evaluated. Results: Median operative time was 138 min (113–180 min) in the HALDN group and 112 min (91–162 min) in the ODN group (p < 0.05). Warm ischemia time was 87 s (63–150 s) in the HALDN and 81 s (56–123 s) in the ODN groups, respectively (p = 0.13). Both the rate of primary graft function as well as kidney graft function parameters serum creatinine and serum cystatin C 1 year after transplantation showed no statistically significant difference between the two groups of patients. Conclusions: Laparoscopic hand-assisted donor nephrectomy is safe and has no negative impact on the transplanted graft function when compared with open donor nephrectomy.

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Section: Introductionmentioning

confidence: 99%

Early and Late Graft Function after Laparoscopic Hand-Assisted Donor Nephrectomy for Living Kidney Transplantation: Comparison with Open Donor Nephrectomy

et al. 2010

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“…Martin et al 21 showed that, in the case of an experienced laparoscopic surgeon, it took 37 laparoscopic donor nephrectomy procedures to significantly shorten surgical times and time to graft function as well as to reduce the incidence of major postoperative complications compared with that in open donation. Hadjianastasiou et al 22 reported that during the period 2000-2006, 2,509 donor nephrectomies were performed in the UK (including 601 laparoscopic and 1,800 open). They found no difference in major morbidity or mortality between techniques; although operative times were longer in the laparoscopic group, the times shortened and generally became comparable in the latter years.…”

Section: Unsurprisingly Led To Donationmentioning

confidence: 99%

Live donor nephrectomy for kidney transplantation

Şener

Cooper

2008

Nat Rev Urol

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The number of patients with end-stage renal disease is increasing substantially every year around the world. Renal transplantation is the best treatment option to improve survival and quality of life. Although the numbers of living, related and deceased transplant donors has also increased, this growth is insufficient to keep up with the expansion rate of the renal failure population. The introduction of laparoscopic donor nephrectomy has gained widespread acceptance by physicians and patients, and seems to be better than open donor nephrectomy in terms of reduced postoperative pain, quick recovery and improved cosmetic outcomes. Evidence strongly suggests that graft survival is similar in recipients of kidneys from living related and unrelated donors. Fortunately, this information has raised awareness of the suitability of potential live, unrelated donors, including spouses, friends, or even anonymous donors. In this Review we touch on sociological aspects of living related kidney transplantation and review the available and proposed methods of increasing the live donor pool, including organ exchange and desensitization protocols for ABO-incompatible and cross-match-positive donor pairs.

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“…The risk of perioperative and postoperative complications from unilateral laparoscopic nephrectomy is 10-15% [69]. These include, but are not limited to, bleeding, infection, bowel injury, hernia, and postanaesthesia depression.…”

Section: Surgical Complicationsmentioning

confidence: 99%