Hypovitaminosis D in widespread pain: its effect on pain perception, quality of life and nerve conduction studies

Kuru, Pinar; Akyüz, Gülseren; Yağcı, İlker; Giray, Esra

doi:10.1007/s00296-014-3099-7

Cited by 33 publications

(31 citation statements)

References 35 publications

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“…So far, to our knowledge, no one has investigated the VDBP levels in plasma from CWP patients. However, it is more common to analyze vitamin D metabolites, and several studies have found decreased levels in chronic low back pain53 and FMS/CWP patients 54,55. This is in conflict with our result, showing increased levels of both vitamin D and VDBP.…”

Section: Discussioncontrasting

confidence: 99%

Systemic alterations in plasma proteins from women with chronic widespread pain compared to healthy controls: a proteomic study

Wåhlén¹,

Olausson²,

Carlsson³

et al. 2017

JPR

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Chronic widespread pain (CWP) is a complex pain condition that is difficult to treat. The prevalence of CWP approximates ~10% of the general population, with higher prevalence in women. Lack of understanding of molecular mechanisms has been a challenge for diagnosis and treatment of chronic pain. The aim of this study was to explore the systemic protein changes in CWP compared to those in healthy controls (CON). By applying 2-dimensional gel electrophoresis, we analyzed the protein pattern of plasma samples from women with CWP (n=16) and healthy women (n=23). The proteomic data were analyzed using multivariate statistical models, and altered proteins were identified using mass spectrometry. The proteome analysis was further validated by gel-free Western blot. Multivariate statistical data analysis of quantified proteins revealed 22 altered proteins in women with CWP, compared to CON group. Many of the identified proteins are previously known to be involved in different parts of the complement system and metabolic and inflammatory processes, e.g., complement factor B, vitamin D-binding protein, ceruloplasmin, transthyretin and alpha-2-HS-glycoprotein. These results indicate that important systemic protein differences exist between women with CWP and healthy women. Further, this study illustrates the potential use of proteomics to detect biomarkers that may provide new insights into the molecular mechanism(s) of chronic pain. However, further larger investigations are required in order to confirm these findings before it will be possible to identify proteins as potential pain biomarkers for clinical use.

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Section: Discussioncontrasting

confidence: 99%

Systemic alterations in plasma proteins from women with chronic widespread pain compared to healthy controls: a proteomic study

Wåhlén¹,

Olausson²,

Carlsson³

et al. 2017

JPR

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“…There was no association found between vitamin D status and sleep, or any quality‐of‐life domains on the NHP and SF‐36. This is contradictory to previous research in premenopausal women, and women with chronic pain (unlike current study where 74·8% were male), where vitamin D deficiency is associated with worse SF‐36 and NHP quality‐of‐life scores, particularly in vitality, physical and mental component subscores . However, there are many factors that may affect quality of life, in addition to mood and cognitive function.…”

Section: Discussioncontrasting

confidence: 99%

Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury

Jamall

Feeney

Zaw-Linn

et al. 2016

Clinical Endocrinology

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SummaryObjectivesTraumatic brain injury (TBI) is a major cause of long‐term disability with variable recovery. Preclinical studies suggest that vitamin D status influences the recovery after TBI. However, there is no published clinical data on links between vitamin D status and TBI outcomes. The aim was to determine the (i) prevalence of vitamin D deficiency/insufficiency, and associations of vitamin D status with (ii) demographic factors and TBI severity, and with (iii) cognitive function, symptoms and quality of life, in adults after TBI.DesignRetrospective audit of patients seen between July 2009 and March 2015. Serum vitamin D (25‐hydroxy‐cholecalciferol) was categorized as deficient (<40 nmol/l), insufficient (40–70 nmol/l) or replete (>70 nmol/l).PatientsA total of 353 adults seen in tertiary hospital clinic (75·4% lighter skinned, 74·8% male, age median 35·1 year, range 26·6–48·3 year), 0·3–56·5 months after TBI (74·5% moderate–severe).MeasurementsSerum vitamin D concentrations; Addenbrooke's Cognitive Examination (ACE‐R), Beck Depression Inventory‐II (BDI‐II), SF‐36 Quality of Life, Pittsburgh Sleep Quality Index.ResultsIn total, 46·5% of patients after TBI had vitamin D deficiency and 80·2% insufficiency/deficiency. Patients with vitamin D deficiency had lower ACE‐R scores than those of vitamin D replete (mean effect size ± SEM 4·5 ± 2·1, P = 0·034), and higher BDI‐II scores than those of vitamin D insufficient (4·5 ± 1·6, P = 0·003), correcting for age, gender, time since TBI and TBI severity. There was no association between vitamin D status and markers of TBI severity, sleep or quality of life.ConclusionVitamin D deficiency is common in patients after TBI and associated with impaired cognitive function and more severe depressive symptoms.

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“…Although rarely considered in rehabilitation clinics, vitamin D deficiency should be accounted for in the differential diagnosis of pain, as it has been reported to be an important factor . Previous studies suggest that vitamin D plays a role in the etiology of fibromyalgia, and non‐specific musculoskeletal pain and vitamin D deficiency have been identified in these patients .…”

Section: Discussionmentioning

confidence: 99%

Association between serum vitamin D levels and neuropathic pain in rheumatoid arthritis patients: A cross‐sectional study

et al. 2017

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Hypovitaminosis D in widespread pain: its effect on pain perception, quality of life and nerve conduction studies

Cited by 33 publications

References 35 publications

Systemic alterations in plasma proteins from women with chronic widespread pain compared to healthy controls: a proteomic study

Systemic alterations in plasma proteins from women with chronic widespread pain compared to healthy controls: a proteomic study

Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury

Association between serum vitamin D levels and neuropathic pain in rheumatoid arthritis patients: A cross‐sectional study

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