Modified Hemostatic Technique Using Microfibrillar Collagen Hemostat in Endoscopic Endonasal Transsphenoidal Surgery: Technical Note

Fujimoto, Yasunori; Kobayashi, Taisuke; Komori, Masahiro; Mariani, Pedro Paulo; Bor‐Seng‐Shu, Edson; Teixeira, Manoel Jacobsen; Wakayama, Akatsuki; Yoshimine, Toshiki

doi:10.2176/nmc.tn.2014-0024

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Good knowledge of the mechanism of action of different available biosurgical hemostats is critical, with multiple considerations including the patient's anticoagulation status, the rate of bleeding, the presence of thrombocytopenia, fibrinogen level assessment, and many other factors. The choice of a specific biosurgical product should be dependent on the type of surgery, site of bleeding, other anatomic considerations, cost, and preference of the operating neurosurgeon [3,16,32,109,110].…”

Section: Neurosurgical Applicationsmentioning

confidence: 99%

Biosurgical Materials in Neurosurgical Applications: From Pioneers to Leaders

Petit-Me¹,

Stawicki²,

Firstenberg³

et al. 2021

Contemporary Applications of Biologic Hemostatic Agents Across Surgical Specialties [Working Title]

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Hemostasis in neurosurgery has evolved significantly over the past few decades. New advances in hemostatic agents, some developed specifically with neurosurgical applications in mind, allowed for more effective control of difficult intraoperative bleeding. These agents vary in the mechanism of action and each may be indicated in different and often highly specific situations. Here we present a review of the most commonly used hemostatic agents, their mechanism of action and their indications. Focus is placed on key aspects and considerations regarding the use biosurgical materials in neurosurgery, with emphasis on clinical appropriateness and patient safety.

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Section: Neurosurgical Applicationsmentioning

confidence: 99%

Biosurgical Materials in Neurosurgical Applications: From Pioneers to Leaders

Petit-Me¹,

Stawicki²,

Firstenberg³

et al. 2021

Contemporary Applications of Biologic Hemostatic Agents Across Surgical Specialties [Working Title]

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“…Adequate haemostasis in cranial and spinal surgery is the key to good results. Haemostasis can be challenging in many surgical procedures, especially in transsphenoidal surgery or in malignant brain tumours [1]. Although bipolar cautery controls bleeding in large vessels, in malignant gliomas (GBM) it can be very difficult to achieve haemostasis especially in cases of subtotal tumour resection.…”

Section: Introductionmentioning

confidence: 99%

Haemostatic technique in malignant gliomas

Dobran

Somma

Paracino

2022

Neurol Neurochir Pol.

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Introduction.Haemostasis in brain surgery is mandatory to avoid postoperative re-bleeding and a poor outcome. Postoperative intra-cavity haemorrhage is a frequent complication, especially in surgery of malignant gliomas because of the fragility of pathological vessels. Material and methods.In this technical note, we describe our 'compression' technique used to achieve haemostasis in adult patients who underwent surgery for supratentorial malignant gliomas (GBM) at our Institute from January 2019 to January 2022. Peri-operative work-up included clinical status, laboratory data and contrast brain CT, performed at 24 hours after surgery, or earlier for patients with neurological worsening.Results. A total of 82 patients was included in this study, 46 males (57%) and 36 females (43%). A post-operative intra-cavity haemorrhage was documented by postoperative CT-scan in 3/82 patients (3.65%), and the mean surgical time was 3.66 hours. No late bleeding was observed 48 hours after surgery. Conclusions.We have documented the good results of our technique to achieve haemostasis in patients operated for malignant glioma (GBM). The technique described in this study seems to be safe and useful to avoid post-operative bleeding in the surgery of cerebral GBM.

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“…On the basis of their good fibrinogen adsorption, high water absorption, macrophage phagocytosis activation, platelet aggregation promotion, immune activity facilitation, wound infection prevention, and antimicrobial activity, three promising biomaterials from biomass sources (Carboxymethyl chitosan (CMC), sodium alginate (SA) and collagen) are commonly applied to hemostat for external application, tissue engineering and drug delivery systems. − However, a single-component material could not afford all these properties. For instance, CMC is cross-linked with SA to increase the production of spherical microparticles with a porous surface .…”

Section: Introductionmentioning

confidence: 99%

Microspheres of Carboxymethyl Chitosan, Sodium Alginate, and Collagen as a Hemostatic Agent in Vivo

Jin

et al. 2018

ACS Biomater. Sci. Eng.

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In the search for biocompatible composite microspheres to be used as a hemostatic agent, in a previous study, we designed a novel biomaterial, consisting of composite microspheres containing three natural biological ingredients, carboxymethyl chitosan, sodium alginate and collagen (CSCM). Furthermore, the chemical and physical properties, hemostatic ability, biocompatibility and cytotoxicity were investigated in vitro. In this work, the in vivo hemostatic performance, wound healing, hemocompatibility, histocompatibility, and biodegradability were evaluated by a series of experiments. The results showed that CSCM could both stop bleeding and enhance healing efficiency by accelerating the clotting and the wound closure rate, suggesting that CSCM acts as a hemostat, and enhances wound healing. In addition, the CSCM material had negligible intracutaneous stimulation reactions and no obvious hemolytic reactions. More importantly, CSCM can be degraded in vivo without significant impacts on physiology, biochemistry, and organization. Thus, CSCM may be a useful tool to stop bleeding in emergency conditions in both military and civilian settings.

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Modified Hemostatic Technique Using Microfibrillar Collagen Hemostat in Endoscopic Endonasal Transsphenoidal Surgery: Technical Note

Cited by 5 publications

References 11 publications

Biosurgical Materials in Neurosurgical Applications: From Pioneers to Leaders

Biosurgical Materials in Neurosurgical Applications: From Pioneers to Leaders

Haemostatic technique in malignant gliomas

Microspheres of Carboxymethyl Chitosan, Sodium Alginate, and Collagen as a Hemostatic Agent in Vivo

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