Dietary Patterns and Cognitive Dysfunction in a 12-Year Follow-up Study of 70 Year Old Men

Olsson, Eva; Karlström, Brita; Kilander, Lena; Byberg, Liisa; Cederholm, Tommy; Sjögren, Per

doi:10.3233/jad-140867

Cited by 75 publications

(106 citation statements)

References 55 publications

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“…One study assessed dietary intake with a 24-h recall and a food-composition table that contained ;900 food and drink items (38). Another study used a 7-d food record and a validated precoded menu book (40), and a Health Habits and History Questionnaire including 128 food and drink items was used in one study (54) (Supplemental Table 2). …”

Section: Resultsmentioning

confidence: 99%

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Petersson

Philippou

2016

Advances in Nutrition

344

212

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A growing body of evidence suggests that adherence to the Mediterranean diet (MD) may protect against cognitive decline and dementia. Many epidemiologic studies and several randomized controlled trials (RCTs) have found positive effects of the MD on cognitive function, but findings remain inconsistent. The aim of this systematic review was to provide an update on the current knowledge of the effects of the MD on cognitive function, cognitive impairment, Alzheimer disease (AD), and all-type dementia. Five databases were searched-PubMed, Embase, CINAHL, CENTRAL, and PsycINFO (1806 to 25 May 2015)-with the use of prespecified criteria. Human studies that were published in English without any restriction on study type, population assessed, intervention period, follow-up time, or publication date, and that examined the association between adherence to the MD and cognitive function or dementia symptoms (as measured by cognitive function tests), were included. Only primary publication types were included. Thirty-two studies from 25 unique cohorts, including 5 RCTs and 27 observational studies, met the inclusion criteria. The majority of studies showed that the MD was associated with improved cognitive function, a decreased risk of cognitive impairment or decreased risk of dementia, or AD. Three studies found no correlation between the MD and AD, 3 further studies found no association between the MD and cognitive impairment, and 5 studies found no association between the MD and cognitive function. There was large heterogeneity, and studies differed with regard to quality. Based on the findings and the limitations in study design, we conclude that adherence to the MD is associated with better cognitive performance. However, it should be noted that the majority of findings come from epidemiologic studies that provide evidence for a correlation between the MD and cognition but not for a cause-and-effect relation. More controlled trials are required to establish a causational relation. Adv Nutr 2016;7:889-904.

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Section: Resultsmentioning

confidence: 99%

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Petersson

Philippou

2016

Advances in Nutrition

344

212

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“…Next, 307 of the 333 articles were excluded after reading the titles and abstracts, and the remaining 26 full-text articles were estimated for eligibility. Finally, 9 articles were included in the present systematic review and meta-analysis131415161718192021. Reasons for the exclusion of the 17 articles were listed in Supplementary Table 4.…”

Section: Resultsmentioning

confidence: 99%

“…Mediterranean diet (characterizes by a high consumption of fruit, vegetables, legumes, cereals, and unsaturated fatty acids; low consumption of meat and saturated fatty acids; low to moderate consumption of dairy products; moderate to high consumption of fish; and a regular but moderate drinking of alcohol) is reported to have a protective effect of cognitive decline in a substantial number of qualitative researches5678 and quantitative reviews9101112. Recently, 4 cohort studies have been published on this topic, and these high-quality articles included an additional 25,864 participants13141516. However, the findings of the 4 studies were inconsistent, and 2 of these studies observed a non-significant association between Mediterranean diet and cognitive disorders1315.…”

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confidence: 99%

“…Recently, 4 cohort studies have been published on this topic, and these high-quality articles included an additional 25,864 participants13141516. However, the findings of the 4 studies were inconsistent, and 2 of these studies observed a non-significant association between Mediterranean diet and cognitive disorders1315. With the accumulating evidence, we therefore performed an updated systematic review and meta-analysis of prospective cohort studies to assess the influence of adherence to Mediterranean diet in the risk of developing cognitive disorders (including mild cognitive impairment, AD, and dementia).…”

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confidence: 99%

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Adherence to Mediterranean diet and risk of developing cognitive disorders: An updated systematic review and meta-analysis of prospective cohort studies

Sun

2017

Sci Rep

158

102

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Recent articles have presented inconsistent findings on the impact of Mediterranean diet in the occurrence of cognitive disorders; therefore, we performed an updated systematic review and meta-analysis to evaluate the potential association and dose-response pattern with accumulating evidence. We searched the PubMed and the Embase for the records relevant to this topic. A generic inverse-variance method was used to pool the outcome data for continuous variable, and categories of high vs. low, median vs. low of Mediterranean diet score with a random-effects model. Generalized least-squares trend estimation model was used to estimate the potential dose-response patterns of Mediterranean diet score on incident cognitive disorders. We identified 9 cohort studies involving 34,168 participants. Compared with the lowest category, the pooled analysis showed that the highest Mediterranean diet score was inversely associated with the developing of cognitive disorders, and the pooled RR (95% CI) was 0.79 (0.70, 0.90). Mediterranean diet score of the median category was not significantly associated with cognitive disorders. Dose-response analysis indicated a trend of an approximately linear relationship of the Mediterranean diet score with the incident risk of cognitive disorders. Further studies of randomized controlled trials are warranted to confirm the observed association in different populations.

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“…Cases of dementia without neuroimaging or sufficient clinical details in medical records to set a specific subtype diagnosis were classified as unspecified dementia (34). Allcause dementia included AD, vascular dementia, frontotemporal dementia (38), Lewy body dementia (39), unspecified dementia, and Parkinson disease with dementia (38,40).…”

Section: Dementia Diagnosesmentioning

confidence: 99%

Vitamin D is not associated with incident dementia or cognitive impairment: an 18-y follow-up study in community-living old men

Olsson¹,

Byberg

Karlström³

et al. 2017

The American Journal of Clinical Nutrition

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Dietary Patterns and Cognitive Dysfunction in a 12-Year Follow-up Study of 70 Year Old Men

Abstract: We found no strong associations with development of cognitive dysfunction for any of the dietary patterns investigated. However, there was a potentially beneficial association for a Mediterranean-like diet on the development of cognitive dysfunction in the subpopulation.

Cited by 75 publications

References 55 publications

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Adherence to Mediterranean diet and risk of developing cognitive disorders: An updated systematic review and meta-analysis of prospective cohort studies

Vitamin D is not associated with incident dementia or cognitive impairment: an 18-y follow-up study in community-living old men

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