Vascularite cutanée leucocytoclasique induite par la gabapentine

Rached, Slaheddine; Slim, Raoudha; Fathallah, Neila; Ghariani, Najet; Nouira, R.; Sriha, Badreddine; Salem, Chaker Ben

doi:10.2515/therapie/2014034

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Todos os medicamentos prescritos e utilizados pelo paciente desde a admissão até ao momento da reação pruriginosa associada ao surgimento das petéquias foram avaliados minunciosamente. Identificou-se que também há relatos de vasculite leucocitoclástica associado ao uso da quetiapina 9 , gabapentina 10 , ácido acetilsalicílico 11 e heparina 12 . Entretanto, é pouco provável que esses medicamentos tenham desencadeado o problema clínico, exceto pela heparina, pois todos eles já eram utilizados cronicamente em nível domiciliar, sem relatos prévios de casos semelhantes aos apresentados durante a internação hospitalar.…”

Section: Discussionunclassified

A rare case of oxacillin-induced leukocytoclastic vasculitis

Rodrigues,

Paiva,

Martins

2023

Medicina (Ribeirão Preto)

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Leukocytoclastic vasculitis is a pathology whose mechanisms are associated with the process of vascular inflammation. It is estimated that up to 24% of the cases of vasculitis are drug-related, with beta-lactam antimicrobials being one of the pharmacological groups commonly associated with this adverse outcome. Oxacillin, a semisyntheticpenicillin, has a beta-lactam ring that confers biological activity and is most frequently associated with reports of leukocytoclastic vasculitis. However, similar cases related to this antimicrobial are rare, with only three cases identified in the literature. Against this background, we report a fourth case of leukocytoclastic vasculitis in a 56-yearold man, on oxacillin treatment, who developed the vasculitis on the 3rd day of antimicrobial use. In addition to oxacillin suspension, he was treated with 125 mg/day of intravenous methylprednisolone for seven days, followed by 20 mg/day of oral prednisone for four days, resulting in satisfactory remission of the skin lesions and no new adverse outcomes. This case provides further evidence supporting the potential causal relationship between the use of oxacillin and the development of leukocytoclastic vasculitis, albeit a rare occurrence. The positive response to therapeutic interventions, such as oxacillin suspension and corticosteroid treatment, underscores the effectiveness of these approaches in addressing this complication.

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A rare case of oxacillin-induced leukocytoclastic vasculitis

Rodrigues,

Paiva,

Martins

2023

Medicina (Ribeirão Preto)

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“…To our knowledge, we present the fifth published case of LCV secondary to gabapentin [5,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Gabapentin-Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report

Órfão,

Madeira,

Maia Duarte

et al. 2023

Cureus

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Leukocytoclastic vasculitis (LCV) is a type of small vessel vasculitis, characterized by a perivascular neutrophilic inflammatory infiltrate with fibrinoid necrosis and fragmentation of nuclei (“leukocytoclasia”). Although up to half of the cases of LCV are idiopathic, infections and drugs are the most common secondary triggers for this condition. We present the case of an 88-year-old woman who developed an erythematous maculopapular rash on both thighs three days after starting gabapentin for neuropathic leg pain, without other associated symptoms. Skin biopsy was compatible with cutaneous vasculitis with a leukocytoclastic pattern. The skin lesions resolved within about 10 days after discontinuing gabapentin, supporting the diagnosis. To our knowledge, there are only four published cases of LCV secondary to gabapentin. This case highlights the importance of being alert for diagnosing drug-related cutaneous manifestations, even if the drug is used in our daily practice and vasculitis is not a common side effect, since discontinuing the suspected agent is crucial to resolve skin lesions and to avoid more serious complications.

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Gabapentin

2014

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Vascularite cutanée leucocytoclasique induite par la gabapentine

Cited by 5 publications

References 7 publications

A rare case of oxacillin-induced leukocytoclastic vasculitis

A rare case of oxacillin-induced leukocytoclastic vasculitis

Gabapentin-Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report

Gabapentin

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