Association of mastocytosis with inflammatory joint diseases: A series of 31 patients

Hypogammaglobulinemias in infants and toddlers with mastocytosis – a new aspect to analyze?

“…A definite classification of observed hypogammaglobulinemias and statement concerning its clinical significance can be made when the immunodeficiency resolves or any other clinical transition appears (9). Even at the absence of serious infections, the high incidence of hypogammaglobulinemia in our group of patients may have its meaning concerning the prophylaxis and the newly reported higher incidence of autoimmunologic diseases in a group of adult patients with mastocytosis (10).…”

Association between rheumatoid arthritis and systemic mastocytosis: a case report and literature review

“…Recently, Bader-Meunier et al reported the association between mastocytosis and spondyloarthritis in a series of 31 patients. They conclude that mastocytosis was associated with a higher prevalence of SpA and that TNF inhibitors were well tolerated in these patients [38]. On the other hand, inhibiting the c-kit receptor by imatinib, decreased MCs numbers in rheumatoid synovium extracted from patients [39], whereas sulfasalazine, a drug used to treat peripheral SpA, was proven to have an effect on MCs [29].…”

Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy

“…Bone formation and turnover is affected by mast cells products such as histamine tryptase and others that influence the balance between osteoclasts and osteoblasts/bone degrading and bone formation. Mastocitosis is associated with high frequency to inflammatory joint disease [62] as a possible consequence of a dysregulation of the mast cell/regulatory lymphocytes interaction in the immune response, and in both conditions, we observe the alteration of bone mineralization. Bone metabolism alterations in asthma are mostly ascribed to steroid treatment but several observations suggest that this is not the only responsible factor.…”