The treatment of paravertebral malignant mesenchymal tumor pain with cryoablation

Efficacy of Cryoablation to Control Cancer Pain: A Systematic Review

“…The BPI can be used to evaluate the efficacy of cryoablation in new ways, by assessing the worst pain and average pain in the past 24 hours or the pain severity score. In 2006, Callstrom et al .…”

“…Most patients (69%) in that study reported a ≥ 2‐point decrease in average pain over the follow‐up period. In another study, Li et al . investigated the analgesic effect of cryoablation in patients with primary mesenchymal tumors, finding a statistically significant drop in mean severity scores: 25.4% and 52.4%, respectively, at day 1 and after 1 month.…”

“…Only 6 of 22 articles included in this review analyzed the effect of cryoablation on QoL. In those studies, the authors used different questionnaires, including the BPI (mean pain interference score), McGill Quality of Life Questionnaire, European Organisation for Research and Treatment of Cancer (EORTC‐QLQ‐C30) instrument, or the Oswestry Disability Index (ODI).…”

“…Li et al., using the BPI, evaluated patients with malignant mesenchymal tumors, reporting a statistically significant reduction in pain interference scores at 24 hours (17%) and at 1 week (32.1%) post‐treatment. At 1 and 3 months, scores had decreased by 43.4% and 47%, respectively, but this decrease did not reach statistical significance.…”

Comparing the efficacy and safety of cryoablation and microwave ablation in treating paravertebral metastases of rabbit VX2 tumor

“…Tumor in ltration into muscles and nerves can trigger reactive muscle spasms, often leading to intense and refractory pain. Concurrently, as the tumor progresses, it may precipitate pathological fractures and spinal stenosis, culminating in movement disorders or even paralysis, signi cantly compromising the patient's overall quality of life 3,4 .…”