Measurement of retinal function with flash-electroretinography in Chinese patients with hyperlipidemia

Zhang, Bei; Qiu, Qinghua; Yin, Li; Yuan, Yao; Wu, Xinming

doi:10.1007/s00417-014-2726-z

Cited by 7 publications

(8 citation statements)

References 37 publications

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“…Moreover, the retinal function of patients with hyperlipidemia was significantly decreased compared with that of healthy controls, even before the occurrence of pathological changes in the fundus, and BMI values negatively correlated with the OP wave index. 35 Previous studies have demonstrated that an increased BMI was associated with narrower retinal arteriolar and wider venular calibers. 34,36,37 Moreover, overweight and obese people have thinner choroids compared both with normal-weight and underweight individuals.…”

Section: Discussionmentioning

confidence: 98%

Effect of carotid endarterectomy on retinal function in 'asymptomatic' patients with hemodynamically significant carotid artery stenosis

Machalińska¹,

Kowalska-Budek²,

Kawa³

et al. 2017

Polish Archives of Internal Medicine

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Section: Discussionmentioning

confidence: 98%

Effect of carotid endarterectomy on retinal function in 'asymptomatic' patients with hemodynamically significant carotid artery stenosis

Machalińska¹,

Kowalska-Budek²,

Kawa³

et al. 2017

Polish Archives of Internal Medicine

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“…Although there are several case reports characterizing visual and/or retinal function in humans with severe hyperlipidemia resulting in a condition called lipemia retinalis 26–28 , there are few that examine retinal function in humans with moderate hyperlipidemia prior to the onset of clinical visual dysfunction 29 . In the rare human cases where severe hyperlipidemia (>1000 mg/dl) causes visual deficits, function is generally recovered with prompt reduction of lipid levels 26–28 .…”

Section: Discussionmentioning

confidence: 99%

Mechanisms Underlying Early-Stage Changes in Visual Performance and Retina Function After Experimental Induction of Sustained Dyslipidemia

et al. 2018

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Visual and retinal function was measured in a mouse model of chemically induced, sustained dyslipidemia to determine the contribution of dyslipidemia to the pathogenesis of retinopathy in the context of metabolic syndrome. Fifteen male C57BL/6Crl mice were divided into three groups. Poloxamer 407 (P-407), 14.5% w/w was delivered at a rate of 6 µl/day by implanted osmotic mini-pumps either subcutaneously (P-407 SQ) or intraperitoneally (P-407 IP) to P-407-treated mice, whereas saline was administered at the same rate to control mice using only the subcutaneous route of administration. Total cholesterol (TC) and true triglyceride (TG) levels were quantified from plasma. Optomotor responses to stimuli of varying spatial frequency or contrast were used to measure visual acuity and contrast sensitivity. Retinal function was determined using Ganzfeld flash electroretinography (ERG). At 32 days, TC for the P-407 IP group was significantly elevated compared to saline controls (169.4 ± 16.5 mg/dl, 0.001 < P < 0.01). TG levels for both the P-407 SQ (59.3 ± 22.4 mg/dl, 0.01 < P < 0.05) and P-407 IP groups (67.7 ± 18.0 mg/dl, 0.001 < P < 0.01) were significantly elevated relative to controls. Electroretinography demonstrated a very significant decline in the b/a ratio (1.80 ± 0.11, P < 0.01) for the P-407 IP group. The b/a ratio exhibited a moderate, significant correlation with TC levels (r = - 0.4425, P = 0.0392) and a strong, very significant correlation with TG levels (r = - 0.6190, P = 0.0021). Delivery of P-407 via osmotic mini-pump resulted in the sustained, significant elevation of plasma TC and TG levels. This elevation in plasma lipid levels was correlated with a decline in inner retinal function.

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“…This finding indicates that obese patients had longer peak times of the rod-mediated response compared with their lean counterparts. Indeed, the retinal function of patients with hyperlipidemia was significantly decreased compared with healthy controls, even before the occurrence of pathological changes in the fundus, and BMI values were negatively correlated with the OP wave index [37]. …”

Section: Discussionmentioning

confidence: 99%

Association between Asymptomatic Unilateral Internal Carotid Artery Stenosis and Electrophysiological Function of the Retina and Optic Nerve

Machalińska

Kowalska-Budek

Kawa

et al. 2017

Journal of Ophthalmology

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Purpose. This study was designed to assess retinal and optic nerve bioelectrical function in patients with unilateral asymptomatic but hemodynamically significant internal carotid artery stenosis (ICAS). Methods. Forty-two subjects with a diagnosis of unilateral ICAS and 34 controls were analyzed. Full-field electroretinogram (ERG), pattern electroretinogram (PERG), and pattern visual-evoked potentials, as well as optical coherence tomography and ophthalmological examination, were performed. Data analysis included eyes ipsilateral to ICAS (EIS) and eyes contralateral to ICAS (ECS). Results. Intraocular pressure was significantly decreased in EIS and ECS compared to that in the controls. In the macula, both the cube average thickness and cube volume values were significantly reduced both in EIS and ECS compared to those in the controls. Similarly, PERG P50 and N95 wave amplitudes were significantly smaller in EIS and ECS compared to those in the controls. The ERG rod b-wave and rod-cone a-wave amplitudes were decreased, and implicit times were significantly prolonged, whereas the OP wave index was reduced in EIS compared to that in the controls. No differences in IOP, OCT, or ERG and PERG parameters were identified between EIS and ECS. Conclusions. Our study demonstrated that retinal bioelectrical function is negatively affected by ICAS despite the absence of objective clinical signs and symptoms of ocular ischemia.

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Measurement of retinal function with flash-electroretinography in Chinese patients with hyperlipidemia

Abstract: The present study suggests that the retinal function of hyperlipidemia patients was significantly lower than in healthy controls, even before the occurrence of pathological changes in the fundus.

Cited by 7 publications

References 37 publications

Effect of carotid endarterectomy on retinal function in 'asymptomatic' patients with hemodynamically significant carotid artery stenosis

Effect of carotid endarterectomy on retinal function in 'asymptomatic' patients with hemodynamically significant carotid artery stenosis

Mechanisms Underlying Early-Stage Changes in Visual Performance and Retina Function After Experimental Induction of Sustained Dyslipidemia

Association between Asymptomatic Unilateral Internal Carotid Artery Stenosis and Electrophysiological Function of the Retina and Optic Nerve

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