Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring

Xia, Yucen; Qi, Fangfang; Zou, Juntao; Yang, Jiliang; Ye, Zhibin

doi:10.1016/j.bbi.2014.06.202

Cited by 37 publications

(37 citation statements)

References 55 publications

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“…Recent researches also provide excellent evidence that stress-induced hippocampal neurogenesis alteration in DG is accompanied by Th1/Th2 balance changing in the periphery [8,9]. Together with our recent studies [10,11], we have proposed a concept that underlying mechanism of immune system affecting the CNS is not just regulated by a certain cytokine but rather regulated by many cytokines [12], which are correlated with systemic Th1/Th2 cytokine balance, for modulation of elaborated brain functions. Importantly, other reports indeed shed light on the correlation between systemic Th1/Th2 balance and adult hippocampal neurogenesis [8,13]; although recent data indicate that the dichotomous categorization of helper T lymphocyte into Th1 and Th2 has become gradually blurred.…”

Section: Introductionsupporting

confidence: 58%

“…Although Th1-type cytokines (IFN-γ, TNF-a et al) are regard as pro-inflammatory factors implicated in the detrimental effects of neural proliferation and Th2-type cytokines (IL-4, IL-10 et al) are anti-inflammatory factors, it is likely that proper cytokine balance is sufficient to modulate hippocampal neurogenesis for normal homeostasis in brain. In our recent studies, influenza vaccination including A (H1N1) vaccine and Seasonal vaccine elicit Th1 like serum cytokine response accompanied by a remarkable neurobeneficial profile of cytokines and neurotrophic factors in the hippocampus [10,12]. Notably, systemic Th1/Th2 bias in this review is not pathological, but in normal range.…”

Section: Resultsmentioning

confidence: 76%

“…In contrast, high levels of IFN-γ inhibits adult hippocampal neurogenesis via the activation of other pro-inflammatory cytokines such as TNF-a, IL-1β, IL-6. These results imply that low-level inflammatory cytokines aid neurogenesis but high-level ones impair neurogenesis, reminiscent of cytological changes following homeostatic neurogenic niche [12]. For another thing, the role of IL-4 on neurogenesis and cognitive function is well documented, but the explanations for it are very controversial.…”

Section: How Systemic Th1/th2 Cytokine Balance Modulates Adult Hippocmentioning

confidence: 99%

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Immune-Based Modulation of Adult Hippocampal Neurogenesis, Link to Systemic Th1/Th2 Balance

Qi¹,

Xia²,

Zuo³

et al. 2015

J Vaccines Vaccin

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The interaction between adaptive immune system and the Central Nervous System (CNS) has been extensively studied for decades. A series of researches have indicated that systemic T cells, particularly CD4 + T cells are involved in supporting fundamental processes of brain functional integrity, such as in the maintenance of brain plasticity including spatial learning and memory, and neurogenesis. Moreover, recent data from our laboratory indicate alteration of systemic T helper cell type 1 (Th1)/Th2 balance is tightly linked to hippocampal neurogenesis and working memory. In this review, we summarize current knowledge of the systemic Th1/Th2 balance, describe how this skewing appears to operate in hippocampal neurogenesis, and reinforce the theory of interaction mechanism of these two vital systems.

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Section: Introductionsupporting

confidence: 58%

Section: Resultsmentioning

confidence: 76%

Section: How Systemic Th1/th2 Cytokine Balance Modulates Adult Hippocmentioning

confidence: 99%

See 1 more Smart Citation

Immune-Based Modulation of Adult Hippocampal Neurogenesis, Link to Systemic Th1/Th2 Balance

Qi¹,

Xia²,

Zuo³

et al. 2015

J Vaccines Vaccin

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“…The data were analyzed by one-way ANOVA or 2-way ANOVA with repeated measures. 23,25 All data are expressed as the means § SEM, and P < 0.05 was considered significant.…”

Section: Discussionmentioning

confidence: 99%

“…22 Serial coronal sections of 40 mm thick, 240 mm apart were collected on a freezing microtome (Leica SM2000R). 23 The sections were stored at 4 C before immunohistochemistry was performed. Actual section thickness was measured, and appropriate guard zones of the section were defined.…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

Continuous vaccinations of 4Aβ1-15 induces specific fluctuation of inflammatory factors accompany with pathologic alterations alleviation in APP/PS1 mice

Zhang¹,

Zou³

et al. 2015

Human Vaccines & Immunotherapeutics

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#These authors equally contributed to this work.Keywords: Ab burdens, APP/PS1 mice, continuous vaccinations, immunotherapy, inflammatory factors, microglial activation spatial learning and memory ability, specific fluctuationsAbbreviations: 4Ab1-15, 4 alternative tandem repeats of GPGPG-linked Ab1-15 sequences; Ab, b-amyloid; APP, amyloid precursor protein; IFN-g, interferon-g; IgG, immunoglobulin G; IL-1b, interleukin-1b; IL-4, interleukin-4; PS1, presenilin-1; Th, T-helper type; TNF-a, tumor necrosis factor-aThe common pathological hallmark of Alzheimer's disease (AD) is b-amyloid plaques deposition. Immunotherapy is a revolutionary pharmacological treatment for AD, aiming at improving plaque clearance while concomitantly decreasing inflammation. Our previous study prepared antigen 4Ab1-15 and found that it could alleviate pathologic alterations in APP/PS1 transgenic mice. The objective of our study was to research the changing processes induced by immunotherapy, including the inflammatory factor levels and microglial activation that is closely associated with Ab burdens clearance. APP/PS1 mice were injected with 4Ab1-15 6 times. Each time, the inflammatory factors in sera were detected, and a specific fluctuation that first increased and then decreased was found, in which there was a turning point after the third injection. It prompted us to further detect the indicators in the brains after the third injection and the sixth injection. The results showed that the therapeutic effects for Ab burdens and behaviors were continuously improved during the whole immune processes, whereas the inflammatory factor levels and microglial activation experienced similar specific fluctuations. The novel discovery may provide convenient methods for further detection and evaluation of immunotherapy in disease courses.

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Neuroteratology and Animal Modeling of Brain Disorders

Archer

Kostrzewa

2015

Current Topics in Behavioral Neurosciences

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Over the past 60 years, a large number of selective neurotoxins were discovered and developed, making it possible to animal-model a broad range of human neuropsychiatric and neurodevelopmental disorders. In this paper, we highlight those neurotoxins that are most commonly used as neuroteratologic agents, to either produce lifelong destruction of neurons of a particular phenotype, or a group of neurons linked by a specific class of transporter proteins (i.e., dopamine transporter) or body of receptors for a specific neurotransmitter (i.e., NMDA class of glutamate receptors). Actions of a range of neurotoxins are described: 6-hydroxydopamine (6-OHDA), 6-hydroxydopa, DSP-4, MPTP, methamphetamine, IgG-saporin, domoate, NMDA receptor antagonists, and valproate. Their neuroteratologic features are outlined, as well as those of nerve growth factor, epidermal growth factor, and that of stress. The value of each of these neurotoxins in animal modeling of human neurologic, neurodegenerative, and neuropsychiatric disorders is discussed in terms of the respective value as well as limitations of the derived animal model. Neuroteratologic agents have proven to be of immense importance for understanding how associated neural systems in human neural disorders may be better targeted by new therapeutic agents.

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Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring

Cited by 37 publications

References 55 publications

Immune-Based Modulation of Adult Hippocampal Neurogenesis, Link to Systemic Th1/Th2 Balance

Immune-Based Modulation of Adult Hippocampal Neurogenesis, Link to Systemic Th1/Th2 Balance

Continuous vaccinations of 4Aβ1-15 induces specific fluctuation of inflammatory factors accompany with pathologic alterations alleviation in APP/PS1 mice

Neuroteratology and Animal Modeling of Brain Disorders

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