Time to Recovery From Lateropulsion Dependent on Key Stroke Deficits

Babyar, Suzanne; Peterson, Margaret G. E.; Reding, Michael

doi:10.1177/1545968314541330

Cited by 46 publications

(18 citation statements)

References 23 publications

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“…33 Advocating for more time in rehabilitation may be indicated for patients with large lesion size, more severe lateropulsion and multiple sensorimotor deficits. 9 Lesions of the inferior parietal lobe are associated with the development of lateropulsion in this sample. The inferior parietal cortex appears to hold a central role in the pathway for evaluating and integrating somatosensory, visual, and vestibular inputs.…”

Section: Lesion Sizementioning

confidence: 77%

“…7 Patients with lateropulsion have delayed functional recovery, 3,8 especially when right-sided brain lesions are present. 9,10 Novel strategies, 11,12 such as transcranial neuromodulation techniques, could augment functional recovery, but these approaches are most likely to be effective if guided by neuroanatomical mechanisms underlying lateropulsion.…”

Section: Introductionmentioning

confidence: 99%

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Lesion Localization of Poststroke Lateropulsion

Babyar

Smeragliuolo

Albazron

et al. 2019

Stroke

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Background and Purpose: Hemispheric stroke studies associating lateropulsion (pusher syndrome) with the location of brain lesions have had mixed results from small, unmatched samples. This study was designed to determine whether lateropulsion localizes to specific brain regions across patients with stroke using a case-control design. Methods: Fifty patients with lateropulsion following stroke were matched with 50 stroke patients without lateropulsion using age, time since onset of stroke, admission motor Functional Independence Measure (FIM) score, lesion side and gender. The primary analysis included multivariate lesion symptom mapping using sparse canonical correlations to identify regions most associated with lateropulsion as assessed with the Burke Lateropulsion Scale. Secondary analyses included evaluating paired comparisons for lesion volume, degree of motor impairment, motor and cognitive FIM scores. Results: The lesion symptom mapping analysis of all lesions mapped onto a common hemisphere produced an overall significant model (P < 5 × 10 −5) with a regional peak at the

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Section: Lesion Sizementioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Lesion Localization of Poststroke Lateropulsion

Babyar

Smeragliuolo

Albazron

et al. 2019

Stroke

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“…This robustness for the cortical vestibular system corresponds with the clinical experience with respect to cortical vestibular lesions (Raiser et al 2020). There are no chronic vestibular symptoms (> 3 months) from supratentorial vestibular node injury (Babyar et al 2015;Brandt and Dieterich 2017). To analyse differences in activations during both stimulations in general, we defined the contrasts to include the main effects for GVS applied on the left and right mastoid and for both the left and the right GNS experiments.…”

Section: Effects On Functional Network Architecturementioning

confidence: 99%

Delineating neural responses and functional connectivity changes during vestibular and nociceptive stimulation reveal the uniqueness of cortical vestibular processing

et al. 2021

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Vestibular information is ubiquitous and often processed jointly with visual, somatosensory and proprioceptive information. Among the cortical brain regions associated with human vestibular processing, area OP2 in the parietal operculum has been proposed as vestibular core region. However, delineating responses uniquely to vestibular stimulation in this region using neuroimaging is challenging for several reasons: First, the parietal operculum is a cytoarchitectonically heterogeneous region responding to multisensory stimulation. Second, artificial vestibular stimulation evokes confounding somatosensory and nociceptive responses blurring responses contributing to vestibular perception. Furthermore, immediate effects of vestibular stimulation on the organization of functional networks have not been investigated in detail yet. Using high resolution neuroimaging in a task-based and functional connectivity approach, we compared two equally salient stimuli—unilateral galvanic vestibular (GVS) and galvanic nociceptive stimulation (GNS)—to disentangle the processing of both modalities in the parietal operculum and characterize their effects on functional network architecture. GNS and GVS gave joint responses in area OP1, 3, 4, and the anterior and middle insula, but not in area OP2. GVS gave stronger responses in the parietal operculum just adjacent to OP3 and OP4, whereas GNS evoked stronger responses in area OP1, 3 and 4. Our results underline the importance of considering this common pathway when interpreting vestibular neuroimaging experiments and underpin the role of area OP2 in central vestibular processing. Global network changes were found during GNS, but not during GVS. This lack of network reconfiguration despite the saliency of GVS may reflect the continuous processing of vestibular information in the awake human.

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“…Postural control deficits are frequent and one of the most disabling problems in stroke survivors. These deficits alter the ability to maintain or change position [ 1 ] and are related to the lower quality of life [ 2 ] and longer time to recovery from stroke [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Verticality Perceptions Associate with Postural Control and Functionality in Stroke Patients

et al. 2016

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Deficits of postural control and perceptions of verticality are disabling problems observed in stroke patients that have been recently correlated to each other. However, there is no evidence in the literature confirming this relationship with quantitative posturography analysis. Therefore, the objectives of the present study were to analyze the relationship between Subjective Postural Vertical (SPV) and Haptic Vertical (HV) with posturography and functionality in stroke patients. We included 45 stroke patients. The study protocol was composed by clinical interview, evaluation of SPV and HV in roll and pitch planes and posturography. Posturography was measured in the sitting and standing positions under the conditions: eyes open, stable surface (EOSS); eyes closed, stable surface (ECSS); eyes open, unstable surface (EOUS); and eyes closed, unstable surface (ECUS). The median PV in roll plane was 0.34° (-1.44° to 2.54°) and in pitch plane 0.36° (-2.72° to 2.45°). The median of HV in roll and pitch planes were -0.94° (-5.86° to 3.84°) and 3.56° (-0.68° to 8.36°), respectively. SPV in the roll plane was correlated with all posturagraphy parameters in sitting position in all conditions (r = 0.35 to 0.47; p < 0.006). There were moderate correlations with the verticality perceptions and all the functional scales. Linear regression model showed association between speed and SPV in the roll plane in the condition EOSS (R2 of 0.37; p = 0.005), in the condition ECSS (R2 of 0.13; p = 0.04) and in the condition EOUS (R2 of 0.22; p = 0.03). These results suggest that verticality perception is a relevant component of postural control and should be systematically evaluated, particularly in patients with abnormal postural control.

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Time to Recovery From Lateropulsion Dependent on Key Stroke Deficits

Cited by 46 publications

References 23 publications

Lesion Localization of Poststroke Lateropulsion

Lesion Localization of Poststroke Lateropulsion

Delineating neural responses and functional connectivity changes during vestibular and nociceptive stimulation reveal the uniqueness of cortical vestibular processing

Verticality Perceptions Associate with Postural Control and Functionality in Stroke Patients

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