Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial

Schuetz, Philipp; Kutz, Alexander; Grolimund, Eva; Haubitz, Sebastian; Demann, Désirée; Vögeli, Alaadin; Hitz, Fabienne; Christ‐Crain, Mirjam; Thomann, Robert V.; Falconnier, Claudine; Hoess, Claus; Henzen, Christoph; Marlowe, Robert J.; Zimmerli, Werner; Müeller, Beat

doi:10.1016/j.ijcard.2014.06.022

Cited by 64 publications

(52 citation statements)

References 29 publications

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“…As was already reported in the original trial, the primary endpoint (mortality and intensive care unit admission) did not significantly differ between the two study groups (PCT‐guided vs. standard management), but antibiotic exposure was significantly shorter in the PCT‐guided group, as were antibiotic side effects. Even more compelling was that in the group of patients with low PCT (<0.05 ng/mL), patients with PCT guidance had better outcome 21. Recently, a study on intensive care unit patients confirmed that antibiotic treatment can be safely guided by repetitive PCT measurements and that this transfers into a lower mortality 22…”

Section: Procalcitonin As a Marker To Guide Antibiotic Therapy In Acumentioning

confidence: 99%

The role of procalcitonin in acute heart failure patients

2017

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Acute dyspnoea is a common chief complaint in the emergency department and is mainly caused by cardiac and pulmonary underlying diagnoses. In patients with acute heart failure (AHF), an early initiation of adequate therapy is important to improve patient outcome. Clinical differentiation of pulmonary and cardiac underlying causes and of concomitant pathologies determines which therapeutic strategy is chosen.Procalcitonin is a marker of bacterial infection, which is markedly increased in AHF patients with concomitant bacterial infection and thus has the potential to guide the early initiation of adequate antibiotic therapy. The IMPACT‐EU trial is a multicenter randomized controlled trial designed to test this hypothesis.This mini‐review summarizes the current literature on procalcitonin in AHF and explains the design of the IMPACT‐EU trial.

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Section: Procalcitonin As a Marker To Guide Antibiotic Therapy In Acumentioning

confidence: 99%

The role of procalcitonin in acute heart failure patients

2017

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“…In patients with acute dyspnea, plasma PCT has been used to differentiate between acute heart failure (AHF) and superimposed pneumonia [2,3]. In this setting, it has shown to be a promissory marker to guide antibiotic treatment and prevent adverse outcomes.…”

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confidence: 99%

Determinants of procalcitonin concentration in acute heart failure

Mollar

Villanueva

Carratalá

et al. 2014

International Journal of Cardiology

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“…In 6 of the 7 cases, at least 1 record met the inclusion criteria of the systematic review [14][15][16][17][18][19]. Reviewer screening time took on average between 30 and 40 minutes.…”

Section: Resultsmentioning

confidence: 99%

Supplementary searches of PubMed to improve currency of MEDLINE and MEDLINE In-Process searches via Ovid

Duffy

Kock

Misso

et al. 2017

jmla

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Objective: The research investigated whether conducting a supplementary search of PubMed in addition to the main MEDLINE (Ovid) search for a systematic review is worthwhile and to ascertain whether this PubMed search can be conducted quickly and if it retrieves unique, recently published, and ahead-of-print studies that are subsequently considered for inclusion in the final systematic review.Methods: Searches of PubMed were conducted after MEDLINE (Ovid) and MEDLINE In-Process (Ovid) searches had been completed for seven recent reviews. The searches were limited to records not in MEDLINE or MEDLINE In-Process (Ovid).Results: Additional unique records were identified for all of the investigated reviews. Search strategies were adapted quickly to run in PubMed, and reviewer screening of the results was not time consuming. For each of the investigated reviews, studies were ordered for full screening; in six cases, studies retrieved from the supplementary PubMed searches were included in the final systematic review.Conclusion: Supplementary searching of PubMed for studies unavailable elsewhere is worthwhile and improves the currency of the systematic reviews. When conducting comprehensive literature searches for systematic reviews of health care interventions, searchers almost always include one bibliographic database, MEDLINE. MEDLINE content can be searched via several search interfaces, the majority of which are provided by fee-based subscription services (e.g., Ovid, EBSCO, or ProQuest), although it can be accessed for free using PubMed. When searching for systematic reviews, PubMed has been shown to have a higher retrieval rate than fee-based versions of MEDLINE, such as Ovid [1]. PubMed enables users to search MEDLINE, PubMed citations that will never be indexed on MEDLINE, and other sources, such as online books. Despite this and the fact that PubMed is freely available, many information specialists prefer to search using sophisticated interfaces (usually fee-based) that enable the design of complex search strategies.PubMed has relatively limited search capabilities. For example, proximity searching is not possible and truncation is limited to the first 600 variations. The lack of proximity search operators can be a significant hindrance when attempting to conduct searches for systematic reviews in PubMed, as phrase searching or use of the Boolean ''AND'' to combine terms are the only alternatives. This can produce a search strategy that is either too precise when using phrases or too sensitive when using the Boolean ''AND.'' Searching MEDLINE via more sophisticated interfaces enables much greater flexibility when conducting searches for systematic reviews, allowing information specialists to find a better balance between precision and sensitivity that is not possible in PubMed.Migration of records from PubMed into fee-based subscription services is usually quite timely. Studies indicate that indexed MEDLINE records and

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Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial

Cited by 64 publications

References 29 publications

The role of procalcitonin in acute heart failure patients

The role of procalcitonin in acute heart failure patients

Determinants of procalcitonin concentration in acute heart failure

Supplementary searches of PubMed to improve currency of MEDLINE and MEDLINE In-Process searches via Ovid

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