25 Years of Research in Human Lactation: From Discovery to Translation

Geddes, Donna T.; Gridneva, Zoya; Perrella, Sharon L.; Mitoulas, Leon R.; Kent, Jacqueline C.; Stinson, Lisa F.; Lai, Ching Tat; Sakalidis, Vanessa S.; Twigger, Alecia-Jane; Hartmann, Peter

doi:10.3390/nu13093071

Cited by 43 publications

(54 citation statements)

References 331 publications

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“…We would like to thank Eric Thorstensen and Joshua Potaka for laboratory analysis, all participants in the DIAMOND and those in the study group: Mariana Muelbert 1 , Tanith Alexander 1,2 , Laura Galante 1 , Sharin Asadi 1 , Clara Y.L. Chong 1 , Jane M. Alsweiler 3,4 , Friederike Beker 5,6 , Frank H. Bloomfield 1,3 , David Cameron-Smith 1 , Caroline A. Crowther 1 , Jane E. Harding 1 , Yannan Jiang 7 , Michael P. Meyer 2,4 , Amber Milan 1,8 , Justin M. O'Sullivan 1 , Clare R. Wall 9 . 1 Liggins Institute, University of Auckland, Auckland, New Zealand.…”

Section: Acknowledgmentsmentioning

confidence: 99%

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Glucocorticoids in preterm human milk

Muelbert

Alexander²,

Vickers³

et al. 2022

Front. Nutr.

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BackgroundGlucocorticoids (GCs), cortisol and cortisone, are essential regulators of many physiological responses, including immunity, stress and mammary gland function. GCs are present in human milk (HM), but whether maternal and infant factors are associated with HM GC concentration following preterm birth is unclear.Materials and methodsHM samples were collected on postnatal day 5 and 10 and at 4 months’ corrected age (4m CA) in a cohort of moderate- and late-preterm infants. GCs in HM were measured by liquid chromatography-tandem mass spectrometry. Relationships between GCs in HM and both maternal and infant characteristics were investigated using Spearman’s correlations and linear mixed models.Results170 mothers of 191 infants provided 354 HM samples. Cortisol concentrations in HM increased from postnatal day 5–4m CA (mean difference [MD] 0.6 ± 0.1 ng/ml, p < 0.001). Cortisone concentration did not change across lactation but was higher than cortisol throughout. Compared to no antenatal corticosteroid (ANS), a complete course of ANS was associated with lower GC concentrations in HM through to 4m CA (cortisol: MD –0.3 ± 0.1 ng/ml, p < 0.01; cortisone MD –1.8 ± 0.4 ng/ml, p < 0.001). At 4m CA, higher maternal perceived stress was negatively associated with GC concentrations in HM (cortisol adjusted beta-coefficient [aβ] –0.01 ± 0.01 ng/ml, p = 0.05; and cortisone aβ –0.1 ± 0.03 ng/ml, p = 0.01), whereas higher postpartum depression and maternal obesity were associated with lower cortisone concentrations (aβ –0.1 ± 0.04 ng/ml p < 0.05; MD [healthy versus obese] –0.1 ± 0.04 ng/ml p < 0.05, respectively). There was a weak positive correlation between GC concentrations in HM and gestational age at birth (r = 0.1, p < 0.05). Infant birth head circumference z-score was negatively associated with cortisol concentrations (aβ –0.01 ± 0.04 ng/ml, p < 0.05). At hospital discharge, fat-free mass showed a weak positive correlation with cortisol concentrations (r = 0.2, p = 0.03), while fat mass showed a weak negative correlation with cortisone concentrations (r = –0.25, p < 0.001).ConclusionThe mammary gland appears to protect the infant from cortisol through inactivation into cortisone. Maternal and infant characteristics were associated with concentration of GCs in HM, including ANS, stress and depression scores, obesity, gestational age and infant size. The effects of HM glucocorticoids on long-term health outcomes requires further research.

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Section: Acknowledgmentsmentioning

confidence: 99%

“…2 Neonatal Unit, Kidz First, Middlemore Hospital, Auckland, New Zealand. 3 Newborn Services, Auckland City Hospital, Auckland, New Zealand. 4 Department of Paediatrics:…”

Section: Acknowledgmentsmentioning

confidence: 99%

Glucocorticoids in preterm human milk

Muelbert

Alexander²,

Vickers³

et al. 2022

Front. Nutr.

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“…Exclusive breastfeeding during the first six months of life delivers a plethora of short- and long-term health benefits [ 1 , 2 ]. Human milk provides a constant supply of bacterial microbiota and bioactive molecules, such as human milk oligosaccharides (HMOs), to the infant during early life, contributing to intestinal homeostasis, immune development, and protection against infection [ 2 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Human Milk Oligosaccharides and Bacterial Profile Modulate Infant Body Composition during Exclusive Breastfeeding

Cheema

Gridneva

Fürst

et al. 2022

IJMS

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Human milk is a complex and variable ecosystem fundamental to the development of newborns. This study aimed to investigate relationships between human milk oligosaccharides (HMO) and human milk bacterial profiles and infant body composition. Human milk samples (n = 60) were collected at two months postpartum. Infant and maternal body composition was measured with bioimpedance spectroscopy. Human milk bacterial profiles were assessed using full-length 16S rRNA gene sequencing and 19 HMOs were quantitated using high-performance liquid chromatography. Relative abundance of human milk bacterial taxa were significantly associated with concentrations of several fucosylated and sialylated HMOs. Individual human milk bacteria and HMO intakes and concentrations were also significantly associated with infant anthropometry, fat-free mass, and adiposity. Furthermore, when data were stratified based on maternal secretor status, some of these relationships differed significantly among infants born to secretor vs non-secretor mothers. In conclusion, in this pilot study the human milk bacterial profile and HMO intakes and concentrations were significantly associated with infant body composition, with associations modified by secretor status. Future research designed to increase the understanding of the mechanisms by which HMO and human milk bacteria modulate infant body composition should include intakes in addition to concentrations.

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“…Human milk (HM) is typically the sole food source for the infants in the first 6 months of life, through which they acquire all elements necessary for their growth and development [1,2]. HM provides a constant supply of micro-and macronutrients, bioactive molecules including carbohydrates (lactose and glucose) and hormones (insulin) to the infant during early life, ensuring appropriate nutrition, maturation, and protection against infection and growth [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Human Milk Lactose, Insulin, and Glucose Relative to Infant Body Composition during Exclusive Breastfeeding

et al. 2021

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Human milk (HM) components may influence infant growth and development. This study aimed to investigate relationships between infant body composition (BC) and HM lactose, insulin, and glucose (concentrations and calculated daily intakes (CDI)) as well as 24-h milk intake and maternal BC at 3 months postpartum. HM samples were collected at 2 months postpartum. Infant and maternal BC was assessed with bioimpedance spectroscopy. Statistical analysis used linear regression accounting for infant birth weight. 24-h milk intake and CDI of lactose were positively associated with infant anthropometry, lean body mass and adiposity. Higher maternal BC measures were associated with lower infant anthropometry, z-scores, lean body mass, and adiposity. Maternal characteristics including BC and age were associated with concentrations and CDI of HM components, and 24-h milk intake. In conclusion, 24-h intake of HM and lactose as well as maternal adiposity are related to development of infant BC.

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25 Years of Research in Human Lactation: From Discovery to Translation

Cited by 43 publications

References 331 publications

Glucocorticoids in preterm human milk

Glucocorticoids in preterm human milk

Human Milk Oligosaccharides and Bacterial Profile Modulate Infant Body Composition during Exclusive Breastfeeding

Human Milk Lactose, Insulin, and Glucose Relative to Infant Body Composition during Exclusive Breastfeeding

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