25-OH Vitamin D Levels and Cognitive Performance: Longitudinal Assessment in a Healthy Aging Cohort

Carvalho, André; Santos, Nadine Correia; Portugal‐Nunes, Carlos; Castanho, Teresa Costa; Moreira, Pedro Silva; Costa, Patrício; Sousa, Nuno; Palha, Joana Almeida

doi:10.3389/fnagi.2019.00330

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…However, there have also been contrasting findings. In a rather small study of 64 non- demented, older Portuguese subjects, Carvalho et al did not find significant cross-sectional or longitudinal correlations between baseline 25(OH)D and composite scores of executive and memory function [ 51 ]. The present study expands existing knowledge significantly by combining in depth cognitive testing with advanced MRI analyses of structural brain atrophy and mass spectrometric measurements of vitamin D metabolites in a single cohort of substantial size.…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study

Zelzer

Hofer

Meinitzer

et al. 2021

Aging

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Background: Vitamin D is a well-established regulator of calcium and phosphate metabolism that has neurotrophic and neuroprotective properties. Deficiency of vitamin D has been proposed to promote cognitive dysfunction and brain atrophy. However, existing studies provide inconsistent results. Here we aimed to investigate the association between vitamin D metabolites, cognitive function and brain atrophy in a cohort of well-characterized community-dwelling elderly individuals with normal neurological status and without history of stroke and dementia. Methods: 25(OH)D 3 , 25(OH)D 2 and 24,25(OH) 2 D 3 were measured by liquid-chromatography tandem mass-spectrometry in serum samples from 390 community-dwelling elderly individuals. All participants underwent thorough neuropsychiatric tests capturing memory, executive function and visuopractical skills. In 139 of these individuals, MRI of the brain was performed in order to capture neurodegenerative and vascular changes. Results: Total 25(OH)D (ß=0.003, 0.037), 24,25(OH) 2 D 3 (ß=0.0456, p=0.010) and vitamin D metabolite ratio (VMR) (ß=0.0467, p=0.012) were significantly related to memory function. Adjustment for multiple testing weakened these relationships, but trends (p≤0.10) remained. 24,25(OH) 2 D 3 and VMR showed similar trends also for visuopractical skills and global cognitive function. No significant relationships existed between vitamin D metabolites and MRI derived indices of neurodegeneration and vascular changes. Sub-group analyses of individuals with low concentrations of 25(OH)D and 24,25(OH) 2 D 3 showed significantly worse memory function compared to individuals with normal or high concentrations. Conclusions: Vitamin D deficient individuals appear to have a modest reduction of memory function without structural brain atrophy. Future studies should explore if vitamin D supplementation can improve cognitive function.

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Section: Discussionmentioning

confidence: 99%

Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study

Zelzer

Hofer

Meinitzer

et al. 2021

Aging

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“…The LC‐MS/MS assay did not assess stereoisomers. Nonetheless, previous literature has suggested negligible 25(OH)D2 levels as low as <1% of D2 + D3 concentrations [32]. We were also unable to assess the impact of supplementation on clinical outcomes, such as mortality and mechanical ventilation.…”

Section: Discussionmentioning

confidence: 89%

Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency

Covington,

Jasper‐Trotter,

Arnold

et al. 2023

Fundamemntal Clinical Pharma

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BackgroundVitamin D deficiency is a common finding in critically ill children. However, the optimal supplementation strategy in this patient population is unknown. The objective of this study was to evaluate the effects of high‐dose (10 000 IU/kg, max. 400 000 IU) vitamin D supplementation on 25‐hydroxyvitamin D3 (25[OH]D3) levels in pediatric intensive care unit (PICU) patients with baseline vitamin D deficiency.MethodsThis was a prospective, institutional review board‐approved pilot research study performed at the University of South Alabama Women's and Children's Hospital in Mobile, AL. The study sample consisted of patients less than 18 years old admitted to the PICU with baseline 25‐hydroxyvitamin D (25[OH]D) level less than 30 ng/ml. Included patients received a one‐time dose of vitamin D3 orally or via gastric tube (10 000 IU/kg, max. 400 000 IU).ResultsA total of 17 patients were screened with 11 included in the study. Blood analysis revealed a significant increase in 25(OH)D3 level from baseline to 12‐h post dose (21.6 [4.5] ng/ml vs. 46.7 [15.5] ng/ml, P < 0.001). At the 12‐h post‐dose time point, 10/11 patients (91%) had 25(OH)D3 levels that were greater than 30 ng/ml. No adverse effects were observed.ConclusionVitamin D3 supplementation at a dose of 10 000 IU/kg (max. 400 000 IU) significantly increased 25(OH)D3 levels in critically ill pediatric patients.

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“…Vitamin D could thus provide an interesting additional therapy for neuropsychiatric symptoms in patients with AD, which is particularly relevant since antipsychotic drugs are suspected of increasing the risk of death in patients with AD [ 87 ]. However, there are also studies reporting no significant association between vitamin D levels, AD, and cognitive function, with vitamin D supplementation providing no benefit [ 88 , 89 ]. The inhomogeneous study situation might be partly due to methodological/logical reasons such as a high variability in dosage and dosage form of the administered vitamin D preparations or a small number of participants and short observation periods.…”

Section: Alzheimer’s Disease and Vitamin D Analoguesmentioning

confidence: 99%

Vitamin D and Its Analogues: From Differences in Molecular Mechanisms to Potential Benefits of Adapted Use in the Treatment of Alzheimer’s Disease

Thiel

Hermanns²,

Lauer

et al. 2023

Nutrients

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Lifestyle habits and insufficient sunlight exposure lead to a high prevalence of vitamin D hypovitaminosis, especially in the elderly. Recent studies suggest that in central Europe more than 50% of people over 60 years are not sufficiently supplied with vitamin D. Since vitamin D hypovitaminosis is associated with many diseases, such as Alzheimer’s disease (AD), vitamin D supplementation seems to be particularly useful for this vulnerable age population. Importantly, in addition to vitamin D, several analogues are known and used for different medical purposes. These vitamin D analogues differ not only in their pharmacokinetics and binding affinity to the vitamin D receptor, but also in their potential side effects. Here, we discuss these aspects, especially those of the commonly used vitamin D analogues alfacalcidol, paricalcitol, doxercalciferol, tacalcitol, calcipotriol, and eldecalcitol. In addition to their pleiotropic effects on mechanisms relevant to AD, potential effects of vitamin D analogues on comorbidities common in the context of geriatric diseases are summarized. AD is defined as a complex neurodegenerative disease of the central nervous system and is commonly represented in the elderly population. It is usually caused by extracellular accumulation of amyloidogenic plaques, consisting of amyloid (Aβ) peptides. Furthermore, the formation of intracellular neurofibrillary tangles involving hyperphosphorylated tau proteins contributes to the pathology of AD. In conclusion, this review emphasizes the importance of an adequate vitamin D supply and discusses the specifics of administering various vitamin D analogues compared with vitamin D in geriatric patients, especially those suffering from AD.

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25-OH Vitamin D Levels and Cognitive Performance: Longitudinal Assessment in a Healthy Aging Cohort

Cited by 7 publications

References 43 publications

Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study

Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study

Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency

Vitamin D and Its Analogues: From Differences in Molecular Mechanisms to Potential Benefits of Adapted Use in the Treatment of Alzheimer’s Disease

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