25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV in Abidjan

Boyvin, Lydie; Aké, Jeanne; Séri, Kipré Laurent; M’boh, Gervais Melaine; Yapo, Adou Francis; Djaman, Joseph Allico

doi:10.9734/ijbcrr/2017/34351

Cited by 4 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this our study, calcium levels are normal, however we observed hyperphosphatemia in all HIV-infected individuals. This confirms the disruption of phosphocalcic balance reported by Boyvin et al [6]. This situation is thought to be due to vitamin D deficiency [23] as observed in this study among PLHIV.…”

Section: Discussionsupporting

confidence: 92%

“…In Côte d'Ivoire, few studies about the mechanism of regulation of phosphocalcic homeostasis in HIV-positive Ivorian patients have been undertaken [6]. The main objective of this study was therefore to determine the 25hydroxyvitamin D 3 and parathyroid status of HIVpositive patients.…”

Section: Concerningmentioning

confidence: 99%

“…During HIV infection, the virus uses nutrients, including micronutrients of the body, for replication [4]. This causes disorders of mineral metabolism, including phosphocalcic [5,6]. The regulation of calcium and phosphorus homeostasis involves parathyroid hormone (PTH), vitamin D 3 (25-hydroxyvitamin D 3 ) and calcitonin [7].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D Deficiency and Evaluation of the Parathyroid Hormone Status in People Living with HIV in Côte d’Ivoire

Aké

Boyvin

Séri

et al. 2018

AJRB

Self Cite

View full text Add to dashboard Cite

Background: Micronutrients play an important role in the human immune system. During HIV infection, the virus utilises the micronutrients of the body, for its replication causing metabolic disorders including phosphocalcic. Parathyroid hormone (PTH), vitamin D3 (25-hydroxyvitamin D3) and calcitonin are essential for the maintenance of phosphocalcic homeostasis and the proper functioning of the body. In Côte d'Ivoire, very few studies on HIV infection and the mechanism of phosphocalcic metabolism have been done. The purpose of this study was to determine the status of 25 (OH) D3 and parathyroid hormone in people living with HIV. Methodology: The study involved 326 adults (163 HIV-positive and 163 HIV-negative as control subjects). After confirmation by HIV serologic scanning result, CD4 count was performed by flow cytometry (Facs Calibur). Assays for 25 (OH) D3 and PTH were performed by HPLC and COBAS 6000 automated systems, respectively. Results: A decrease in mean values of 25 (OH) D3 (16 ± 0.46 ng / mL) was observed in 50% of HIV-infected on ART and 87% of these patients presented a normal PTH level (28 ± 1.95 pg / mL). Deficiency of 25 (OH) D3 (20 ± 1.03 ng / mL) is higher in HIV-infected on ART who have a CD4 count < 200 cells / mL. Conclusion: Parathyroid hormone levels were normal in this study. Insufficiency or deficiency of 25-hydroxyvitamin D3 is more common in HIV-infected on ART with a CD4 count < 200 cells / mL. This decrease characterized the degree of immunodepression.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Concerningmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D Deficiency and Evaluation of the Parathyroid Hormone Status in People Living with HIV in Côte d’Ivoire

Aké

Boyvin

Séri

et al. 2018

AJRB

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this study we found that 9% of healthy subjects presented vitamin D deficiency [defined as 25(OH)D levels <20 ng/mL]. This is much lower than results obtained in a recent study conducted in Abidjan that found the prevalence of vitamin D deficiency in a control population of 110 HIV-negative subjects was 33% [22]. One of the reasons for this discrepancy is the assay used for 25(OH)D measurements.…”

Section: Discussioncontrasting

confidence: 55%

Vitamin D, bone alkaline phosphatase and parathyroid hormone in healthy subjects and haemodialysed patients from West Africa: impact of reference ranges and parathyroid hormone generation assays on the KDIGO guidelines

Cavalier

Yayo

Attoungbre-Hauhouot

et al. 2018

Clinical Kidney Journal

View full text Add to dashboard Cite

Background The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend targets based on multiples of the upper limit of normal (ULN) of parathyroid hormone (PTH) concentration. However, the ULN has not always been correctly established by manufacturers. While it is known that the ULN is supposed to be higher in African Americans than in Caucasians, it is largely unknown in Africans. Methods We established the ULN of PTH concentration in a population of 240 healthy Ivorians using second- and third-generation PTH assays before and after supplementation with 100 000 IU of cholecalferol. We measured the levels of PTH, bone alkaline phosphatase, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in 100 haemodialysed Ivorian patients. Results The prevalence of vitamin D deficiency in Ivory Coast is low. The ULN obtained using the third-generation PTH assay was similar to that obtained in Caucasians but was higher when PTH was measured using the second-generation PTH assay. According to the KDIGO guidelines, ∼20% of the haemodialysed patients were below twice the ULN and 30% were above nine times the ULN. Approximately 25% of the patients were even >12 times the ULN. We observed a discrepancy in the results between the two PTH assays (14%) that was relatively more important than what we observed from previous studies in Caucasians using the same strategy. Conclusions We found a low prevalence of vitamin D deficiency in a tropical country like Ivory Coast. We also established the PTH reference range, which could prove useful for the follow-up of haemodialysed patients, particularly for the large number of patients suffering from secondary hyperparathyroidism who are at high risk of adverse bone events.

show abstract

“…The analysis was carried out using commercially prepared spectrum diagnostic kits. 0cresolphthalein complexone method for Calcium, Fiske and Subbarow method for Phosphorus, and 5-Bromo-PAPS method was used for Zinc the assay were performed spectrophotometrically using Genrui-semiautomated chemistry analyzer [15].…”

Section: Calcium Phosphorus and Zinc Estimationmentioning

confidence: 99%

Estimation of Serum Minerals, Total Protein and Liver Enzymes in HIV Patients Receiving Haart in Federal Medical Centre, Keffi, Nasarawa State, Nigeria

Gbolahan,

Victoria,

Ugbomoiko

et al. 2023

AJRB

View full text Add to dashboard Cite

Aims: This study was aimed to estimate serum minerals level (calcium, zinc, phosphorus), total protein and liver enzymes (ALT and AST) in patients taking HAART at Federal Medical Centre Keffi, Nasarawa state. Nigeria. Study design: This study engaged a cross-sectional study design to investigate the liver enzyme alterations and the level of serum minerals in patients taking HAART when compare with treatment naïve (Pre-HAART) controls. Place and duration of the study: The study was conducted in Federal Medical Center Keffi, Nasarawa State-Nigeria. Data collection spanned a specific duration from December, 2022 to March, 2023. Method: A total of 143 subjects were involved in the study of which were 59 HIV positive patients on HAART, 34 Pre-HAART patients and 50 healthy subjects served as controls. 5ml venous blood sample was collected after taking aseptic precaution from the study subjects into plain vacuum tubes; sample was left for 30 minutes at room temperature and centrifuged at 3000 rpm for 4 minutes. Sero-negativity of the control (healthy patients) was confirmed by HIV TRI-DOT test. Serum total calcium, serum phosphorus, serum zinc. Total proteins were estimated using spectrophotometer while AST and ALT were estimated by colorimetric method. Result: The study indicated that both pre-HAART and HAART patients showed significantly higher (P<.05) AST and ALT activities compared to sero-negative patients. Pre-HAART patients had lower Zinc (11.22±4.86) and TP (43.18±22.52) levels than sero-negative patients, with Zinc (16.58±4.20) and TP (65.47±12.79). In contrast, HAART patients experienced a significant increase (P<.005) in Zinc (14.29±3.41) and TP (61.56±18.87) levels compared to pre-HAART patients (11.22±4.86) and (43.18±2.52). No significant difference in serum calcium level in all groups. Patients on HAART and sero-negative patients displayed normal Phosphorus level which is significantly higher in pre-HAART patients. Conclusion: This study concluded that the serum level of ALT and AST were increased in HIV positive patients on HAART and pre-HAART patients. HAART improved level of serum zinc and total protein.

show abstract

25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV in Abidjan

Cited by 4 publications

References 18 publications

Vitamin D Deficiency and Evaluation of the Parathyroid Hormone Status in People Living with HIV in Côte d’Ivoire

Vitamin D Deficiency and Evaluation of the Parathyroid Hormone Status in People Living with HIV in Côte d’Ivoire

Vitamin D, bone alkaline phosphatase and parathyroid hormone in healthy subjects and haemodialysed patients from West Africa: impact of reference ranges and parathyroid hormone generation assays on the KDIGO guidelines

Estimation of Serum Minerals, Total Protein and Liver Enzymes in HIV Patients Receiving Haart in Federal Medical Centre, Keffi, Nasarawa State, Nigeria

Contact Info

Product

Resources

About