25(OH) D3 Vitamin Serum Levels Associated With Chronic Sarcoidosis

Vucinic, Violeta; Šumarac, Zorica; Vukovic, Mira; Stjepanović, Mihailo; Omcikus, Maja; Videnovic, Jelica; Škodrić-Trifunović, Vesna; Filipović, Snežana

doi:10.1378/chest.1118989

Cited by 3 publications

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“…So, results of the current study implies in the role of vitamin 25(OH)D deficiencies in leading the course of sarcoidosis to chronicity. This confirmed an earlier study on 25(OH)D deficiencies correlation with course of chronic sarcoidosis and data from 86 sarcoidosis patients with 29.5% of acute patients with 25(OH)D deficiency and 64.2% of chronic patients with 25(OH)D deficiencies (5).…”

Section: Discussionsupporting

confidence: 90%

“…Negative association was reported between 25-hydroxy vitamin D, active sarcoidosis, sarcoidosis chronicity and pulmonary function status in sarcoidosis patients, in recent studies (1, 4, 5, 18). But, correlation of 25-(OH)D status with sarcoidosis factors has not been yet studied in Iranian sarcoidosis population.…”

Section: Objectivesmentioning

confidence: 88%

“…Several studies have advocated that the innate immune failure in responding to persistent antigens causes Granuloma formation of sarcoidosis (1, 2, 3). Sarcoidosis disease occurs in winter and in regions with increased latitude in which lack of sun-exposure leads to vitamin D deficiency (4, 5). Vitamin D pro hormone plays many potential roles in immune regulatory structure (5, 3).…”

Section: Introductionmentioning

confidence: 99%

“…Sarcoidosis disease occurs in winter and in regions with increased latitude in which lack of sun-exposure leads to vitamin D deficiency (4, 5). Vitamin D pro hormone plays many potential roles in immune regulatory structure (5, 3). As explained in third national health and nutrition survey, vitamin D deficiency is associated with sarcoidosis prevalence (6).…”

Section: Introductionmentioning

confidence: 99%

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Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Kiani¹,

Abedini²,

Adcock³

et al. 2018

Journal of Medical Biochemistry

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SummaryBackgroundDespite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency with sarcoidosis chronicity, disease activity, extra-pulmonary skin manifestations, urine calcium level and pulmonary function status in Iranian sarcoidosis patients. Results of this study along with future studies, will supply more effective programs for sarcoidosis treatment.MethodsEighty sarcoidosis patients in two groups of insufficient serum level and sufficient serum level of 25-hydroxy vitamin D were studied. Course of sarcoidosis was defined as acute and chronic sarcoidosis. Pulmonary function test (PFT) was assessed by spirometry. Skin involvements were defined as biopsy proven skin sarcoidosis. 24-hour urine calcium level was used to specify the disease activity. Stages of lung involvements were obtained by CT-scan and chest X-ray. The statistical analyses were evaluated using Statistical Package for the Social Sciences.ResultsA significant negative correlation was obtained between vitamin D deficiency in sarcoidosis patients and disease chronic course and stages two to four of lung involvements. Considering other parameters of the disease and vitamin D deficiency, no significant correlation was detected.ConclusionsIn conclusion, results of the current study implies in the role of vitamin 25(OH)D deficiencies in predicting the course of chronic sarcoidosis. Furthermore, it was concluded that vitamin 25(OH)D deficiency can direct pulmonary sarcoidosis toward stage 2–4 of lung involvements.

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Section: Discussionsupporting

confidence: 90%

Section: Objectivesmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Kiani¹,

Abedini²,

Adcock³

et al. 2018

Journal of Medical Biochemistry

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“…There are some important reflections associated with vitamin D in sarcoidosis; the observations are not due merely to secondar y osteoporosis or calcium metabolism disorders, as would be expected, but to immune response in general, thus leading inevitably to the discussion on vitamin D and its role not only in bone health issues in sar coidosis but beyond. R ecently, many effects of vitamin D have been shown to occur outside the feedback contr ol of the osseousendocrine loop; these effects ar e also independent from serum calcium, phosphorus or PTH levels (2).…”

Section: Introductionmentioning

confidence: 99%

THE role of vitamin D in multisystem sarcoidosis

Mihailović-Vučinić¹,

Videnović-Ivanov²,

Filipović³

et al. 2012

Pneumologie

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Recently published data indicate that vitamin D abnormalities are common in sar coidosis patients. The purpose of this study was to compar e serum vitamin 25(OH)D levels among sarcoidosis patients with differ ent clinical courses of the disease. The study also included the first obser vations on cognitive functions (i.e. depr ession and fatigue syndrome) in r elation to vitamin D deficiency in sar coidosis patients. At the Biochemical Laboratory of the Clinical Center of Serbia, Belgrade, vitamin D25(OH)D was measur ed using the Elecsys ® Vitamin D total test. A total of 226 patients with biopsy-positive sarcoidosis were analyzed. The average median value of ser um vitamin D was 9.47 mg/L, suggesting severe deficiency. Statistically significant cor relation was found in patients with chronic disease and low levels of serum vitamin 25(OH)D (Chi-Squar e=6.044; df=2; p=0.014). The patient group with vitamin D serum levels higher than 20 mg/L showed higher levels of the mean for ced vi tal capacity (FVC) by 380 mL, and for ced expiratory volume in one second (FEV1) by 220 mL, when compared to the patient group with lower serum vitamin D. A statistically significant role was established for serum vitamin 25(OH)D levels as the pr edictor of fatigue (R 2 =0.878; p=0.038 (b=0.216)) and depression in patients with sar coidosis (R 2 =0.8 0; p=0.000 (b=0.391)). The insufficiency of 25(OH)D seems to be an important factor in pr edicting the course of chr onic disease, significant lung function impair ments and cognitive failur es such as fatigue and depr ession. The fact that the majo rity of the analyzed sarcoidosis patients had totally deficient ser um 25(OH)D levels made this finding even mor e notable.

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The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

Mihailović-Vučinić¹,

Ignjatović²,

Dudvarski-Ilić³

et al. 2012

Journal of Medical Biochemistry

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Summary: Recently published data indicate that vitamin D abnormalities are common in sarcoidosis patients. The purpose of this study was to compare serum vitamin 25(OH)D levels among sarcoidosis patients with different clinical courses of the disease. The study also included the first observations on cognitive functions (i.e. depression and fatigue syndrome) in relation to vitamin D deficiency in sarcoidosis patients. At the Biochemical Laboratory of the Clinical Center of Serbia, Belgrade, vitamin D25(OH)D was measured using the Elecsys ® Vitamin D total test. A total of 226 patients with biopsy-positive sarcoidosis were analyzed. The average median value of serum vitamin D was 9.47 mg/L, suggesting severe deficiency. Statistically significant correlation was found in patients with chronic disease and low levels of serum vitamin 25(OH)D (Chi-Square=6.044; df=2; p=0.014). The patient group with vitamin D serum levels higher than 20 mg/L showed higher levels of the mean forced vi tal capacity (FVC) by 380 mL, and forced expiratory volume in one second (FEV1) by 220 mL, when compared to the patient group with lower serum vitamin D. A statistically significant role was established for serum vitamin 25(OH)D levels as the predictor of fatigue (R 2 =0.878; p=0.038 (b=0.216)) and depression in patients with sarcoidosis (R 2 =0.80; p=0.000 (b=0.391)). The insufficiency of 25(OH)D seems to be an important factor in predicting the course of chronic disease, significant lung function impairments and cognitive failures such as fatigue and depression. The fact that the majo rity of the analyzed sarcoidosis patients had totally deficient serum 25(OH)D levels made this finding even more notable. Keywords: vitamin D, deficiency, sarcoidosisKratak sadr`aj: Nedavno objavljena istra`ivanja kod obole lih od sarkoidoze govore o ~estim abnormalnim vrednostima vitamina D. Cilj ove studije bio je da se uporedi nivo vita mina 25(OH)D kod obolelih od sarkoidoze sa razli~itim klini~kim tokom bolesti. Tako|e, ova studija predstavlja prva za pa `anja o vezi izme|u kognitivnih funkcija (odnosno ose}a ja depresije i zamora) i deficita vitamina D kod obolelih od sarko idoze. U Biohemijskoj laboratoriji Klini~kog centra Srbije vitamin D -25(OH)D meren je kori{}enjem testa Elec sys ® Vitamin D. Analizirano je 226 bolesnika sa sarkoidozom potvr|enom biopsijom. Prose~na srednja vrednost vitamina D u serumu bila je 9,47 mg/L, {to ukazuje na ozbiljan nedostatak. Statisti~ki zna~ajna korelacija na |e na je kod pa cije nata sa hroni~nom formom bolesti i niskim nivoom vitamina 25(OH)D u serumu (Xi-kvad rat=6,044; df=2; p=0,014). Grupa pacijenata sa nivoom vitamina D u serumu ve}im od 20 mg/L pokazuje ve}i nivo srednjeg for siranog vitalnog kapaciteta (FVC) za 380 mL i forsiranog ekspi ratornog volumena u prvoj sekundi (FEV1) za 220 mL u od nosu na grupu pacijenata sa ni`im nivoom D vitamina. Utvr|eno je da nivo vitamina 25(OH)D u serumu ima stati sti~ki zna~ajnu ulogu kao prediktor zamora i depresije kod obolelih od sarkoidoze. Insuficijencija 25(OH)D ...

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25(OH) D3 Vitamin Serum Levels Associated With Chronic Sarcoidosis

Cited by 3 publications

References 0 publications

Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

THE role of vitamin D in multisystem sarcoidosis

The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

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