25(oh)d as a Risk Factor of Essential Arterial Hypertension Considering the Genes Polymorphism Agtr1 (Rs5186) and VDR (Rs2228570)

Abstract

Objective:Essential arterial hypertension (EAH) remains the most common global non-communicable disease. More than 50% of patients with hypertension have additional cardiovascular risk factors. The aim of this study is to establish the role of 25-hydroxyvitamin D as an additional risk factor of EAH depending on 1166A>C polymorphism of AGTR1 gene (rs5186) and A/G polymorphism of VDR gene (rs2228570).Design and method:100 subjects with EAH and target-organ damaging (2nd stage), moderate, high, very high cardiovascular risk were involved in the case-control study. Among them, 70.84% females, 29.16% males, mean age 57.86 ± 7.81 yo. The control group consisted of 60 healthy individuals of relevant gender and age. All recruited subjects were tested for serum levels 25-hydroxyvitamin D (immune luminescent test “MAGLUMI’’, “SNIB’’, China). To detect gene polymorphism the qualitative real-time polymerase chain reaction was done. AGTR1 gene genotyping was performed for 72 patients and 48 healthy individuals and VDR gene – for 100 patients and 60 healthy subjects.Results:EAH associates with the decreased 25-hydroxyvitamin D (<30 ng/ml) regardless the genotypes AGTR1 (rs5186) and VDR (rs2228570) genes. Reduced serum level of 25-hydroxyvitamin D escalate the risk of EAH almost threefold (OR – 2.90; 95%CI OR:1.0–8.59; p = 0.048).Conclusions:Low level of 25-hydroxyvitamin D increases the EAH risk regardless the AGTR1 (rs5186) and VDR (rs2228570) genes’ alleles in the examined population.

Association of Gene Polymorphisms with Breast Cancer Risk in the Kazakh Population

“…In the study conducted in the Kazakh population, the G/G genotype by rs3803662 polymorphism was statistically less common in tumors with high proliferative activity (immunohistochemical marker . In contrast to these data, some studies found no statistically significant differences between histopathological characteristics and molecular subtypes of breast cancer in the groups of patients with different histological types of breast adenocarcinomas and genotypically detected polymorphisms (Ahearn et al, 2019;Nuruev et al, 2023;Semianiv et al, 2021).…”

Surgical Treatment of Abdominal Aortic Aneurysms

“…Despite reliable data supporting the need for screening to prevent rupture and reduce mortality in patients with AAA, the condition continues to pose a serious risk (15,(26)(27)(28). Screening is economically effective, even with an AAA prevalence as low as 0.5 % (4).…”

Risks’ Stratification of Metabolic Disorders and Arterial Hypertension Depending on the NOS3 (RS2070744) and GNB3 (RS5443) Genes’ Allelic State

“…Критерії включення і невключення наведені у наших попередніх публікаціях [9][10][11][12][13][14][15]. Вік хворих коливався від 45 до 70 років (у середньому -59,87±7,98 року), серед них чоловіків -25,0%, жінок -75,0%.…”

“…Висновки. Ризик розвитку метаболічних розладів зростає у хворих на есенційну артеріальну гіпертензію із Т-алелем гена GNB3 (825С>T) у 8,5 раза за найнижчої ймовірності таких змін у носіїв 12; p=0,048].…”